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Statins and risk of new-onset diabetes mellitus: is there a rationale for individualized statin therapy?
Am J Cardiovasc Drugs 2014; 14(2):79-87AJ

Abstract

Statins (hydroxymethylglutaryl-coenzyme-A reductase inhibitors) are first-line agents for the management of hyperlipidemia in patients at high risk of cardiovascular (CV) events, and are the most commonly prescribed CV drugs worldwide. Although safe and generally well tolerated, there is growing evidence to suggest that statins are associated with an elevated occurrence of new-onset diabetes mellitus (DM). Recent experimental and clinical data have prompted the US Food and Drug Administration to add information to statin labels regarding the increased risk of development of type 2 DM. The main purpose of this review is to critically discuss the clinical evidence regarding the association of statin use with new-onset DM, the CV benefit/risk ratio with statins, and the rationale for individualized statin therapy.

Authors+Show Affiliations

Department of Cardiology and Internal Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Skłodowskiej-Curie Street No 9, 8 094, Bydgoszcz, Poland, eliano.navarese@alice.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24174174

Citation

Navarese, Eliano Pio, et al. "Statins and Risk of New-onset Diabetes Mellitus: Is There a Rationale for Individualized Statin Therapy?" American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions, vol. 14, no. 2, 2014, pp. 79-87.
Navarese EP, Szczesniak A, Kolodziejczak M, et al. Statins and risk of new-onset diabetes mellitus: is there a rationale for individualized statin therapy? Am J Cardiovasc Drugs. 2014;14(2):79-87.
Navarese, E. P., Szczesniak, A., Kolodziejczak, M., Gorny, B., Kubica, J., & Suryapranata, H. (2014). Statins and risk of new-onset diabetes mellitus: is there a rationale for individualized statin therapy? American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions, 14(2), pp. 79-87. doi:10.1007/s40256-013-0053-0.
Navarese EP, et al. Statins and Risk of New-onset Diabetes Mellitus: Is There a Rationale for Individualized Statin Therapy. Am J Cardiovasc Drugs. 2014;14(2):79-87. PubMed PMID: 24174174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statins and risk of new-onset diabetes mellitus: is there a rationale for individualized statin therapy? AU - Navarese,Eliano Pio, AU - Szczesniak,Anna, AU - Kolodziejczak,Michalina, AU - Gorny,Bartosz, AU - Kubica,Jacek, AU - Suryapranata,Harry, PY - 2013/11/1/entrez PY - 2013/11/1/pubmed PY - 2014/12/15/medline SP - 79 EP - 87 JF - American journal of cardiovascular drugs : drugs, devices, and other interventions JO - Am J Cardiovasc Drugs VL - 14 IS - 2 N2 - Statins (hydroxymethylglutaryl-coenzyme-A reductase inhibitors) are first-line agents for the management of hyperlipidemia in patients at high risk of cardiovascular (CV) events, and are the most commonly prescribed CV drugs worldwide. Although safe and generally well tolerated, there is growing evidence to suggest that statins are associated with an elevated occurrence of new-onset diabetes mellitus (DM). Recent experimental and clinical data have prompted the US Food and Drug Administration to add information to statin labels regarding the increased risk of development of type 2 DM. The main purpose of this review is to critically discuss the clinical evidence regarding the association of statin use with new-onset DM, the CV benefit/risk ratio with statins, and the rationale for individualized statin therapy. SN - 1179-187X UR - https://www.unboundmedicine.com/medline/citation/24174174/Statins_and_risk_of_new_onset_diabetes_mellitus:_is_there_a_rationale_for_individualized_statin_therapy L2 - https://dx.doi.org/10.1007/s40256-013-0053-0 DB - PRIME DP - Unbound Medicine ER -