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The effect of rat mast cell sensitization with mouse IgE antibody on anaphylactic histamine release by anti-mouse IgE and Con A.
Arch Immunol Ther Exp (Warsz). 1985; 33(4):531-8.AI

Abstract

The peritoneal mast cells of rat (Wistar X August) F1 were incubated with purified mouse IgE antibodies and then challenged (in the presence of 50% D2O) with antigen, anti-mouse IgE and concanavalin A. It was found that incubation of mast cells with IgE antibodies led to different level of cell sensitization (in mast cells from different rats), expressed in antigen-induced histamine release (0-52%). Moreover, a) significant antigen-induced histamine release was usually accompanied by high Con A- and anti-IgE-induced histamine release from these cells; the magnitude of release was comparable to Con A- and anti-IgE-induced release from control, nonsensitized cells of the same rat; b) low antigen-induced histamine release was accompanied by the decrease of Con A- and anti-IgE-induced release, as compared to the release from control cells. This fall of reactivity to Con A and anti-IgE was statistically significant and was irreversible during 120 min.

Authors

Brzezińska-Błaszczyk E
No affiliation info available
Wyczółkowska J
No affiliation info available

MeSH

AnaphylaxisAnimalsConcanavalin AHistamine ReleaseImmunization, PassiveImmunoglobulin EMaleMast CellsRatsRats, Inbred Strains

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2417574

Citation

Brzezińska-Błaszczyk, E, and J Wyczółkowska. "The Effect of Rat Mast Cell Sensitization With Mouse IgE Antibody On Anaphylactic Histamine Release By Anti-mouse IgE and Con A." Archivum Immunologiae Et Therapiae Experimentalis, vol. 33, no. 4, 1985, pp. 531-8.
Brzezińska-Błaszczyk E, Wyczółkowska J. The effect of rat mast cell sensitization with mouse IgE antibody on anaphylactic histamine release by anti-mouse IgE and Con A. Arch Immunol Ther Exp (Warsz). 1985;33(4):531-8.
Brzezińska-Błaszczyk, E., & Wyczółkowska, J. (1985). The effect of rat mast cell sensitization with mouse IgE antibody on anaphylactic histamine release by anti-mouse IgE and Con A. Archivum Immunologiae Et Therapiae Experimentalis, 33(4), 531-8.
Brzezińska-Błaszczyk E, Wyczółkowska J. The Effect of Rat Mast Cell Sensitization With Mouse IgE Antibody On Anaphylactic Histamine Release By Anti-mouse IgE and Con A. Arch Immunol Ther Exp (Warsz). 1985;33(4):531-8. PubMed PMID: 2417574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of rat mast cell sensitization with mouse IgE antibody on anaphylactic histamine release by anti-mouse IgE and Con A. AU - Brzezińska-Błaszczyk,E, AU - Wyczółkowska,J, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 531 EP - 8 JF - Archivum immunologiae et therapiae experimentalis JO - Arch Immunol Ther Exp (Warsz) VL - 33 IS - 4 N2 - The peritoneal mast cells of rat (Wistar X August) F1 were incubated with purified mouse IgE antibodies and then challenged (in the presence of 50% D2O) with antigen, anti-mouse IgE and concanavalin A. It was found that incubation of mast cells with IgE antibodies led to different level of cell sensitization (in mast cells from different rats), expressed in antigen-induced histamine release (0-52%). Moreover, a) significant antigen-induced histamine release was usually accompanied by high Con A- and anti-IgE-induced histamine release from these cells; the magnitude of release was comparable to Con A- and anti-IgE-induced release from control, nonsensitized cells of the same rat; b) low antigen-induced histamine release was accompanied by the decrease of Con A- and anti-IgE-induced release, as compared to the release from control cells. This fall of reactivity to Con A and anti-IgE was statistically significant and was irreversible during 120 min. SN - 0004-069X UR - https://www.unboundmedicine.com/medline/citation/2417574/The_effect_of_rat_mast_cell_sensitization_with_mouse_IgE_antibody_on_anaphylactic_histamine_release_by_anti_mouse_IgE_and_Con_A_ DB - PRIME DP - Unbound Medicine ER -