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Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs.
BMC Pregnancy Childbirth. 2013 Oct 31; 13:199.BP

Abstract

BACKGROUND

Past studies suggest that maternal vitamin D intake during pregnancy may protect against child wheeze but studies on asthma are limited. Our objective was to examine the relation between intake of vitamin D in mid-pregnancy and child asthma and allergic rhinitis at 18 months and 7 years.

METHODS

We examined data from 44,825 women enrolled during pregnancy in the longitudinal Danish National Birth Cohort (1996-2002). We estimated vitamin D intake from diet and supplements based on information from a validated food frequency questionnaire completed in gestational week 25. At 18 months, we evaluated child asthma using data from phone interviews. We assessed asthma and allergic rhinitis by self-report at age 7 and asthma by using records from national registries. Current asthma at age 7 was defined as lifetime asthma diagnosis and wheeze in the past 12 months. We calculated multivariable risk ratios with 95% CIs comparing highest vs. lowest quintile of vitamin D intake in relation to child allergic disease outcomes.

RESULTS

The median (5%-95%ile) intake of total vitamin D was 11.7(3.0-19.4) μg/day (68% from supplements). In multivariable analysis, mothers in the highest (vs. lowest) quintile of total vitamin D intake were less likely to have children classified with current asthma at 7 years (Q5 vs. Q1: 0.74, 95% CI: 0.56, 0.96, P = 0.02) and they were less likely to have children admitted to the hospital due to asthma (Q5 vs. Q1: 0.80, 95% CI: 0.64, 1.00, P = 0.05). We found no associations with child asthma at 18 months or with allergic rhinitis at 7 years.

CONCLUSIONS

Our findings suggest a weak inverse relationship between high total vitamin D and asthma outcomes in later, but not early, childhood. The data did not suggest a clear threshold of vitamin D intake above which risk of asthma was reduced.

Authors+Show Affiliations

Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark. kmv@ssi.dk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24176134

Citation

Maslova, Ekaterina, et al. "Vitamin D Intake in Mid-pregnancy and Child Allergic Disease - a Prospective Study in 44,825 Danish Mother-child Pairs." BMC Pregnancy and Childbirth, vol. 13, 2013, p. 199.
Maslova E, Hansen S, Jensen CB, et al. Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs. BMC Pregnancy Childbirth. 2013;13:199.
Maslova, E., Hansen, S., Jensen, C. B., Thorne-Lyman, A. L., Strøm, M., & Olsen, S. F. (2013). Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs. BMC Pregnancy and Childbirth, 13, 199. https://doi.org/10.1186/1471-2393-13-199
Maslova E, et al. Vitamin D Intake in Mid-pregnancy and Child Allergic Disease - a Prospective Study in 44,825 Danish Mother-child Pairs. BMC Pregnancy Childbirth. 2013 Oct 31;13:199. PubMed PMID: 24176134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs. AU - Maslova,Ekaterina, AU - Hansen,Susanne, AU - Jensen,Camilla B, AU - Thorne-Lyman,Andrew L, AU - Strøm,Marin, AU - Olsen,Sjurdur F, Y1 - 2013/10/31/ PY - 2013/06/21/received PY - 2013/10/23/accepted PY - 2013/11/2/entrez PY - 2013/11/2/pubmed PY - 2014/8/1/medline SP - 199 EP - 199 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 13 N2 - BACKGROUND: Past studies suggest that maternal vitamin D intake during pregnancy may protect against child wheeze but studies on asthma are limited. Our objective was to examine the relation between intake of vitamin D in mid-pregnancy and child asthma and allergic rhinitis at 18 months and 7 years. METHODS: We examined data from 44,825 women enrolled during pregnancy in the longitudinal Danish National Birth Cohort (1996-2002). We estimated vitamin D intake from diet and supplements based on information from a validated food frequency questionnaire completed in gestational week 25. At 18 months, we evaluated child asthma using data from phone interviews. We assessed asthma and allergic rhinitis by self-report at age 7 and asthma by using records from national registries. Current asthma at age 7 was defined as lifetime asthma diagnosis and wheeze in the past 12 months. We calculated multivariable risk ratios with 95% CIs comparing highest vs. lowest quintile of vitamin D intake in relation to child allergic disease outcomes. RESULTS: The median (5%-95%ile) intake of total vitamin D was 11.7(3.0-19.4) μg/day (68% from supplements). In multivariable analysis, mothers in the highest (vs. lowest) quintile of total vitamin D intake were less likely to have children classified with current asthma at 7 years (Q5 vs. Q1: 0.74, 95% CI: 0.56, 0.96, P = 0.02) and they were less likely to have children admitted to the hospital due to asthma (Q5 vs. Q1: 0.80, 95% CI: 0.64, 1.00, P = 0.05). We found no associations with child asthma at 18 months or with allergic rhinitis at 7 years. CONCLUSIONS: Our findings suggest a weak inverse relationship between high total vitamin D and asthma outcomes in later, but not early, childhood. The data did not suggest a clear threshold of vitamin D intake above which risk of asthma was reduced. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/24176134/Vitamin_D_intake_in_mid_pregnancy_and_child_allergic_disease___a_prospective_study_in_44825_Danish_mother_child_pairs_ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/1471-2393-13-199 DB - PRIME DP - Unbound Medicine ER -