Tags

Type your tag names separated by a space and hit enter

Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study.
Arterioscler Thromb Vasc Biol. 2014 Jan; 34(1):231-6.AT

Abstract

OBJECTIVE

Endothelial dysfunction is a possible mechanism to explain the association between atherosclerosis and kidney disease. This study evaluated circulating soluble endothelial cell-selective adhesion molecule (sESAM), a marker of endothelial dysfunction, as a risk factor for kidney function decline and albuminuria.

APPROACH AND RESULTS

In the Heart and Soul Study, we measured sESAM from baseline serum samples and defined elevated levels of sESAM by the highest quartile (quartile 4 [Q4]: >65.4 ng/mL). We evaluated the associations of high sESAM with baseline estimated glomerular filtration rate (eGFR) and ratio of urine albumin to creatinine (ACR), and with longitudinal changes in eGFR and ACR. Among 990 participants with sESAM measurements, median sESAM was 54.5 ng/mL (interquartile range, 45.3-65.8). After multivariable adjustment, elevated levels of sESAM were strongly and independently associated with baseline reduced eGFR <60 mL/min per 1.73 m(2) (odds ratio [OR], 11.44; P<0.0001) and ACR ≥30 mg/g (OR, 5.23; P<0.0001). Associations of sESAM (Q4 versus quartile 1 [Q1]) with change in ACR (β=54.47; P<0.0001) were also significant after full adjustment. The association with change in eGFR (1.56%; P=0.0049) was not statistically significant after application of the Bonferroni correction for multiple markers. In unadjusted models, sESAM was associated with rapid kidney function loss, defined as 3% annual eGFR decline (OR, 2.28; P=0.0003), although this was attenuated by adjustment (OR, 2.11; P=0.0095).

CONCLUSIONS

sESAM is associated with albuminuria and reduced kidney function in both cross-sectional and longitudinal analyses. These findings implicate endothelial dysfunction as a potential contributor to the elevated kidney disease risk in persons with cardiovascular disease.

Authors+Show Affiliations

From the Division of Nephrology (M.P., C.A.P.), and Departments of Epidemiology and Biostatistics (E.V., M.W., M.G.S.) and Medicine (P.G., M.W., M.G.S.), University of California, San Francisco, CA; Division of Cardiology, San Francisco General Hospital, San Francisco, CA (P.G.); and San Francisco VA Medical Center, San Francisco, CA (M.W., M.G.S.).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24177327

Citation

Park, Meyeon, et al. "Role of Soluble Endothelial Cell-selective Adhesion Molecule Biomarker in Albuminuria and Kidney Function Changes in Patients With Coronary Artery Disease: the Heart and Soul Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 1, 2014, pp. 231-6.
Park M, Vittinghoff E, Ganz P, et al. Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study. Arterioscler Thromb Vasc Biol. 2014;34(1):231-6.
Park, M., Vittinghoff, E., Ganz, P., Peralta, C. A., Whooley, M., & Shlipak, M. G. (2014). Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(1), 231-6. https://doi.org/10.1161/ATVBAHA.113.301806
Park M, et al. Role of Soluble Endothelial Cell-selective Adhesion Molecule Biomarker in Albuminuria and Kidney Function Changes in Patients With Coronary Artery Disease: the Heart and Soul Study. Arterioscler Thromb Vasc Biol. 2014;34(1):231-6. PubMed PMID: 24177327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study. AU - Park,Meyeon, AU - Vittinghoff,Eric, AU - Ganz,Peter, AU - Peralta,Carmen A, AU - Whooley,Mary, AU - Shlipak,Michael G, Y1 - 2013/10/31/ PY - 2013/11/2/entrez PY - 2013/11/2/pubmed PY - 2014/2/19/medline KW - albuminuria KW - atherosclerosis KW - kidney diseases SP - 231 EP - 6 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler Thromb Vasc Biol VL - 34 IS - 1 N2 - OBJECTIVE: Endothelial dysfunction is a possible mechanism to explain the association between atherosclerosis and kidney disease. This study evaluated circulating soluble endothelial cell-selective adhesion molecule (sESAM), a marker of endothelial dysfunction, as a risk factor for kidney function decline and albuminuria. APPROACH AND RESULTS: In the Heart and Soul Study, we measured sESAM from baseline serum samples and defined elevated levels of sESAM by the highest quartile (quartile 4 [Q4]: >65.4 ng/mL). We evaluated the associations of high sESAM with baseline estimated glomerular filtration rate (eGFR) and ratio of urine albumin to creatinine (ACR), and with longitudinal changes in eGFR and ACR. Among 990 participants with sESAM measurements, median sESAM was 54.5 ng/mL (interquartile range, 45.3-65.8). After multivariable adjustment, elevated levels of sESAM were strongly and independently associated with baseline reduced eGFR <60 mL/min per 1.73 m(2) (odds ratio [OR], 11.44; P<0.0001) and ACR ≥30 mg/g (OR, 5.23; P<0.0001). Associations of sESAM (Q4 versus quartile 1 [Q1]) with change in ACR (β=54.47; P<0.0001) were also significant after full adjustment. The association with change in eGFR (1.56%; P=0.0049) was not statistically significant after application of the Bonferroni correction for multiple markers. In unadjusted models, sESAM was associated with rapid kidney function loss, defined as 3% annual eGFR decline (OR, 2.28; P=0.0003), although this was attenuated by adjustment (OR, 2.11; P=0.0095). CONCLUSIONS: sESAM is associated with albuminuria and reduced kidney function in both cross-sectional and longitudinal analyses. These findings implicate endothelial dysfunction as a potential contributor to the elevated kidney disease risk in persons with cardiovascular disease. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/24177327/Role_of_soluble_endothelial_cell_selective_adhesion_molecule_biomarker_in_albuminuria_and_kidney_function_changes_in_patients_with_coronary_artery_disease:_the_Heart_and_Soul_Study_ L2 - https://www.ahajournals.org/doi/10.1161/ATVBAHA.113.301806?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -