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Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease.
J Pediatr Gastroenterol Nutr 2013; 57(5):627-33JP

Abstract

AIMS

Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary intake of fish and ω-3 fatty acids in children with biopsy-proven NAFLD, and examine their association with serological and histological indicators of disease.

METHODS

This was a cross-sectional analysis of 223 children (6-18 years) who participated in the Treatment of Nonalcoholic Fatty Liver Disease in Children trial or the NAFLD Database study conducted by the Nonalcoholic Steatohepatitis Clinical Research Network. The distribution of fish and ω-3 fatty acid intake was determined from responses to the Block Brief 2000 Food Frequency Questionnaire, and analyzed for associations with serum alanine aminotransferase, histological features of fatty liver disease, and diagnosis of steatohepatitis after adjusting for demographic, anthropometric, and dietary variables.

RESULTS

The minority of subjects consumed the recommended 8 ounces of fish per week (22/223 [10%]) and 200 mg of long-chain ω-3 fatty acids per day (12/223 [5%]). Lack of fish and long-chain ω-3 fatty acid intake was associated with greater portal (P = 0.03 and P = 0.10, respectively) and lobular inflammation (P = 0.09 and P = 0.004, respectively) after controlling for potential confounders.

CONCLUSIONS

Fish and ω-3 fatty acid intake was insufficient in children with NAFLD, which may increase susceptibility to hepatic inflammation. Patients with pediatric NAFLD should be encouraged to consume the recommended amount of fish per week.

Authors+Show Affiliations

*University of Hawaii, Honolulu †Washington University, St Louis, MO ‡Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD §Columbia University, New York, NY.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24177784

Citation

St-Jules, David E., et al. "Estimation of Fish and Ω-3 Fatty Acid Intake in Pediatric Nonalcoholic Fatty Liver Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 57, no. 5, 2013, pp. 627-33.
St-Jules DE, Watters CA, Brunt EM, et al. Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2013;57(5):627-33.
St-Jules, D. E., Watters, C. A., Brunt, E. M., Wilkens, L. R., Novotny, R., Belt, P., & Lavine, J. E. (2013). Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. Journal of Pediatric Gastroenterology and Nutrition, 57(5), pp. 627-33. doi:10.1097/MPG.0b013e3182a1df77.
St-Jules DE, et al. Estimation of Fish and Ω-3 Fatty Acid Intake in Pediatric Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2013;57(5):627-33. PubMed PMID: 24177784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. AU - St-Jules,David E, AU - Watters,Corilee A, AU - Brunt,Elizabeth M, AU - Wilkens,Lynne R, AU - Novotny,Rachel, AU - Belt,Patricia, AU - Lavine,Joel E, AU - ,, PY - 2013/11/2/entrez PY - 2013/11/2/pubmed PY - 2014/7/8/medline SP - 627 EP - 33 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 57 IS - 5 N2 - AIMS: Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary intake of fish and ω-3 fatty acids in children with biopsy-proven NAFLD, and examine their association with serological and histological indicators of disease. METHODS: This was a cross-sectional analysis of 223 children (6-18 years) who participated in the Treatment of Nonalcoholic Fatty Liver Disease in Children trial or the NAFLD Database study conducted by the Nonalcoholic Steatohepatitis Clinical Research Network. The distribution of fish and ω-3 fatty acid intake was determined from responses to the Block Brief 2000 Food Frequency Questionnaire, and analyzed for associations with serum alanine aminotransferase, histological features of fatty liver disease, and diagnosis of steatohepatitis after adjusting for demographic, anthropometric, and dietary variables. RESULTS: The minority of subjects consumed the recommended 8 ounces of fish per week (22/223 [10%]) and 200 mg of long-chain ω-3 fatty acids per day (12/223 [5%]). Lack of fish and long-chain ω-3 fatty acid intake was associated with greater portal (P = 0.03 and P = 0.10, respectively) and lobular inflammation (P = 0.09 and P = 0.004, respectively) after controlling for potential confounders. CONCLUSIONS: Fish and ω-3 fatty acid intake was insufficient in children with NAFLD, which may increase susceptibility to hepatic inflammation. Patients with pediatric NAFLD should be encouraged to consume the recommended amount of fish per week. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/24177784/Estimation_of_fish_and_ω_3_fatty_acid_intake_in_pediatric_nonalcoholic_fatty_liver_disease_ L2 - http://dx.doi.org/10.1097/MPG.0b013e3182a1df77 DB - PRIME DP - Unbound Medicine ER -