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Genetic and environmental contributions to sleep-wake behavior in 12-year-old twins.
Sleep 2013; 36(11):1715-22S

Abstract

STUDY OBJECTIVES

To examine the role of genetic and environmental factors on sleep behavior in 12-year-old twins matched for family environment.

DESIGN

Population-based twin cohort.

SETTING

Participants were assessed in their home environment.

PATIENTS OR PARTICIPANTS

One hundred thirty-two adolescent twins comprising 25 monozygotic (MZ) and 41 dizygotic (DZ) twin pairs; aged 12.2 ± 0.1 y (mean ± standard deviation).

INTERVENTIONS

N/A.

MEASUREMENTS AND RESULTS

For 2 weeks in their home environment, participants wore a wrist activity monitor and completed a daily sleep diary. Sleep diaries included reports of bedtime, wake time, and estimated sleep onset time. Mean timing, duration, and quality of sleep during the 2 weeks were calculated for each individual and compared within twin pairs. MZ twin correlations were higher than the DZ correlations for total sleep time (MZr = 0.64; DZr = 0.38) and sleep onset latency (MZr = 0.83; DZr = 0.53) and significantly higher for wake after sleep onset (MZr = 0.66; DZr = 0.04) and sleep efficiency (MZr = 0.82; DZr = 0.10). Univariate modeling showed additive genetic factors accounted for 65% of the variance in total sleep time, 83% in sleep onset latency, and 52% and 57% of the variance in wake after sleep onset and sleep efficiency, respectively. A predominant influence of shared environment was found on the timing of sleep (67% for sleep start time, 86% for sleep end time).

CONCLUSIONS

There is a strong genetic influence on the sleep-wake patterns of 12-year-old adolescents. Genes have a greater influence on sleep initiation and sleep maintenance and a smaller role in sleep timing, likely to be influenced by family environment.

Authors+Show Affiliations

School of Psychology and Psychiatry, Monash University, Melbourne, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

24179306

Citation

Sletten, Tracey L., et al. "Genetic and Environmental Contributions to Sleep-wake Behavior in 12-year-old Twins." Sleep, vol. 36, no. 11, 2013, pp. 1715-22.
Sletten TL, Rajaratnam SM, Wright MJ, et al. Genetic and environmental contributions to sleep-wake behavior in 12-year-old twins. Sleep. 2013;36(11):1715-22.
Sletten, T. L., Rajaratnam, S. M., Wright, M. J., Zhu, G., Naismith, S., Martin, N. G., & Hickie, I. (2013). Genetic and environmental contributions to sleep-wake behavior in 12-year-old twins. Sleep, 36(11), pp. 1715-22. doi:10.5665/sleep.3136.
Sletten TL, et al. Genetic and Environmental Contributions to Sleep-wake Behavior in 12-year-old Twins. Sleep. 2013 Nov 1;36(11):1715-22. PubMed PMID: 24179306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic and environmental contributions to sleep-wake behavior in 12-year-old twins. AU - Sletten,Tracey L, AU - Rajaratnam,Shantha M W, AU - Wright,Margaret J, AU - Zhu,Gu, AU - Naismith,Sharon, AU - Martin,Nicholas G, AU - Hickie,Ian, Y1 - 2013/11/01/ PY - 2013/11/2/entrez PY - 2013/11/2/pubmed PY - 2014/7/26/medline KW - Adolescence KW - environmental influences KW - genetics KW - heritability KW - sleep KW - twins SP - 1715 EP - 22 JF - Sleep JO - Sleep VL - 36 IS - 11 N2 - STUDY OBJECTIVES: To examine the role of genetic and environmental factors on sleep behavior in 12-year-old twins matched for family environment. DESIGN: Population-based twin cohort. SETTING: Participants were assessed in their home environment. PATIENTS OR PARTICIPANTS: One hundred thirty-two adolescent twins comprising 25 monozygotic (MZ) and 41 dizygotic (DZ) twin pairs; aged 12.2 ± 0.1 y (mean ± standard deviation). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: For 2 weeks in their home environment, participants wore a wrist activity monitor and completed a daily sleep diary. Sleep diaries included reports of bedtime, wake time, and estimated sleep onset time. Mean timing, duration, and quality of sleep during the 2 weeks were calculated for each individual and compared within twin pairs. MZ twin correlations were higher than the DZ correlations for total sleep time (MZr = 0.64; DZr = 0.38) and sleep onset latency (MZr = 0.83; DZr = 0.53) and significantly higher for wake after sleep onset (MZr = 0.66; DZr = 0.04) and sleep efficiency (MZr = 0.82; DZr = 0.10). Univariate modeling showed additive genetic factors accounted for 65% of the variance in total sleep time, 83% in sleep onset latency, and 52% and 57% of the variance in wake after sleep onset and sleep efficiency, respectively. A predominant influence of shared environment was found on the timing of sleep (67% for sleep start time, 86% for sleep end time). CONCLUSIONS: There is a strong genetic influence on the sleep-wake patterns of 12-year-old adolescents. Genes have a greater influence on sleep initiation and sleep maintenance and a smaller role in sleep timing, likely to be influenced by family environment. SN - 1550-9109 UR - https://www.unboundmedicine.com/medline/citation/24179306/Genetic_and_environmental_contributions_to_sleep_wake_behavior_in_12_year_old_twins_ L2 - https://academic.oup.com/sleep/article-lookup/doi/10.5665/sleep.3136 DB - PRIME DP - Unbound Medicine ER -