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Lean people with dysglycemia have a worse metabolic profile than centrally obese people without dysglycemia.
Diabetes Technol Ther. 2014 Feb; 16(2):91-6.DT

Abstract

AIM

This study compared metabolic profiles of Asian Indians with normal waist circumference (WC) and dysglycemia versus those with high WC without dysglycemia.

SUBJECTS AND METHODS

In 2,350 subjects ≥20 years of age from the Chennai Urban Rural Epidemiology Study with full anthropometric and biochemical characterization, high WC was defined as ≥90 cm in males and ≥80 cm in females. Dysglycemia was defined as prediabetes (fasting plasma glucose ≥100 mg/dL and/or 2-h plasma glucose ≥140 mg/dL) or diabetes (fasting plasma glucose ≥126 mg/dL, 2-h plasma glucose ≥200 mg/dL, or treatment for diagnosed diabetes). Coronary artery disease (CAD) was defined as known myocardial infarction or Q waves on electrocardiography. Multivariable logistic regression models were used to explore factors associated with CAD.

RESULTS

Of the subjects, 260 (11.1%) had dysglycemia with normal WC, and 679 (28.9%), had high WC without dysglycemia. Compared with subjects with high WC without dysglycemia, those with dysglycemia/normal WC, adjusted for age, were more likely to be males (P<0.001) and have higher systolic blood pressure (P<0.05), higher serum triglycerides (P<0.001), higher tumor necrosis factor-α (P<0.001), lower high-density lipoprotein cholesterol (P<0.05), and higher prevalence of CAD (6.3% vs. 2.0%; odds ratio 3.25 [95% confidence interval 1.52-6.94]; P=0.002).

CONCLUSIONS

Dysglycemia is associated with a worse cardiometabolic profile than central obesity alone.

Authors+Show Affiliations

1 Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre , WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24180326

Citation

Deepa, Mohan, et al. "Lean People With Dysglycemia Have a Worse Metabolic Profile Than Centrally Obese People Without Dysglycemia." Diabetes Technology & Therapeutics, vol. 16, no. 2, 2014, pp. 91-6.
Deepa M, Papita M, Nazir A, et al. Lean people with dysglycemia have a worse metabolic profile than centrally obese people without dysglycemia. Diabetes Technol Ther. 2014;16(2):91-6.
Deepa, M., Papita, M., Nazir, A., Anjana, R. M., Ali, M. K., Narayan, K. M., & Mohan, V. (2014). Lean people with dysglycemia have a worse metabolic profile than centrally obese people without dysglycemia. Diabetes Technology & Therapeutics, 16(2), 91-6. https://doi.org/10.1089/dia.2013.0198
Deepa M, et al. Lean People With Dysglycemia Have a Worse Metabolic Profile Than Centrally Obese People Without Dysglycemia. Diabetes Technol Ther. 2014;16(2):91-6. PubMed PMID: 24180326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lean people with dysglycemia have a worse metabolic profile than centrally obese people without dysglycemia. AU - Deepa,Mohan, AU - Papita,Martina, AU - Nazir,Ahmed, AU - Anjana,Ranjit Mohan, AU - Ali,Mohammed K, AU - Narayan,Kabayam M Venkat, AU - Mohan,Viswanathan, Y1 - 2013/11/04/ PY - 2013/11/5/entrez PY - 2013/11/5/pubmed PY - 2014/9/12/medline SP - 91 EP - 6 JF - Diabetes technology & therapeutics JO - Diabetes Technol Ther VL - 16 IS - 2 N2 - AIM: This study compared metabolic profiles of Asian Indians with normal waist circumference (WC) and dysglycemia versus those with high WC without dysglycemia. SUBJECTS AND METHODS: In 2,350 subjects ≥20 years of age from the Chennai Urban Rural Epidemiology Study with full anthropometric and biochemical characterization, high WC was defined as ≥90 cm in males and ≥80 cm in females. Dysglycemia was defined as prediabetes (fasting plasma glucose ≥100 mg/dL and/or 2-h plasma glucose ≥140 mg/dL) or diabetes (fasting plasma glucose ≥126 mg/dL, 2-h plasma glucose ≥200 mg/dL, or treatment for diagnosed diabetes). Coronary artery disease (CAD) was defined as known myocardial infarction or Q waves on electrocardiography. Multivariable logistic regression models were used to explore factors associated with CAD. RESULTS: Of the subjects, 260 (11.1%) had dysglycemia with normal WC, and 679 (28.9%), had high WC without dysglycemia. Compared with subjects with high WC without dysglycemia, those with dysglycemia/normal WC, adjusted for age, were more likely to be males (P<0.001) and have higher systolic blood pressure (P<0.05), higher serum triglycerides (P<0.001), higher tumor necrosis factor-α (P<0.001), lower high-density lipoprotein cholesterol (P<0.05), and higher prevalence of CAD (6.3% vs. 2.0%; odds ratio 3.25 [95% confidence interval 1.52-6.94]; P=0.002). CONCLUSIONS: Dysglycemia is associated with a worse cardiometabolic profile than central obesity alone. SN - 1557-8593 UR - https://www.unboundmedicine.com/medline/citation/24180326/Lean_people_with_dysglycemia_have_a_worse_metabolic_profile_than_centrally_obese_people_without_dysglycemia_ L2 - https://www.liebertpub.com/doi/10.1089/dia.2013.0198?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -