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Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats.
J Ethnopharmacol 2013; 150(3):1119-27JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Cyclocarya paliurus (CP) Batal., the sole species in its genus and native to China, is a herbal tea, which has been traditionally used in the folk medicine for the treatment of diabetes and hyperlipidemia in China. To evaluate the antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts from CP in high fat diet (HFD) and streptozotocin (STZ) induced diabetic rats.

MATERIALS AND METHODS

Type 2 diabetes was induced in 140 rats by feeding with HFD and high sugar water for 6 weeks and single injection of STZ (30mg/kg, intraperitoneally). CP ethanol extract (CPEE) and aqueous extract (CPAE) at three doses at 2, 4 and 8 g/kg/day were orally administered once daily for four weeks. Blood glucose, serum insulin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), free fatty acid (FFA), total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), blood urea nitrogen (BUN), creatinine (CREA) and glycated serum protein (GSP) were examined. The content of total flavonoids and polysaccharides in CPEE and CPAE were assayed by ultraviolet spectrophotometry.

RESULTS

Both CPEE and CPAE increased OGTT, ITT, HDL-C, SOD and GSH-Px, while they decreased FFA, TC, TG, LDL-C, MDA, BUN, CREA and GSP. The amount of total flavonoids was found in CPEE (30.41 mg/g extract), followed by CPAE (6.75 mg/g extract). Similarly, the polysaccharides content (4.13 mg/g extract) was observed in CPAE, while absent in CPEE.

CONCLUSIONS

The results suggested that CPEE and CPAE exhibited the similar antihyperglycemic, antihyperlipidemic and antioxidant effects in type 2 diabetic rats, and there were no significant differences between these two extracts.

Authors+Show Affiliations

Department of Natural Medicinal Chemistry, China Pharmaceutical University, No.24, Tongjiaxiang, Gulou District, Nanjing 210009, Jiangsu Province, PR China; Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, No. 100, Shizi Street, Hongshan Road, Nanjing 210028, Jiangsu Province, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24184190

Citation

Wang, Qingqing, et al. "Antihyperglycemic, Antihyperlipidemic and Antioxidant Effects of Ethanol and Aqueous Extracts of Cyclocarya Paliurus Leaves in Type 2 Diabetic Rats." Journal of Ethnopharmacology, vol. 150, no. 3, 2013, pp. 1119-27.
Wang Q, Jiang C, Fang S, et al. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J Ethnopharmacol. 2013;150(3):1119-27.
Wang, Q., Jiang, C., Fang, S., Wang, J., Ji, Y., Shang, X., ... Zhang, J. (2013). Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. Journal of Ethnopharmacology, 150(3), pp. 1119-27. doi:10.1016/j.jep.2013.10.040.
Wang Q, et al. Antihyperglycemic, Antihyperlipidemic and Antioxidant Effects of Ethanol and Aqueous Extracts of Cyclocarya Paliurus Leaves in Type 2 Diabetic Rats. J Ethnopharmacol. 2013 Dec 12;150(3):1119-27. PubMed PMID: 24184190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. AU - Wang,Qingqing, AU - Jiang,Cuihua, AU - Fang,Shengzuo, AU - Wang,Junhu, AU - Ji,Yun, AU - Shang,Xulan, AU - Ni,Yicheng, AU - Yin,Zhiqi, AU - Zhang,Jian, Y1 - 2013/10/30/ PY - 2013/05/23/received PY - 2013/10/21/revised PY - 2013/10/23/accepted PY - 2013/11/5/entrez PY - 2013/11/5/pubmed PY - 2014/8/26/medline KW - Antihyperglycemic KW - Antihyperlipidemic KW - Antioxidant KW - Cyclocarya paliurus KW - Type 2 diabetes SP - 1119 EP - 27 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 150 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Cyclocarya paliurus (CP) Batal., the sole species in its genus and native to China, is a herbal tea, which has been traditionally used in the folk medicine for the treatment of diabetes and hyperlipidemia in China. To evaluate the antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts from CP in high fat diet (HFD) and streptozotocin (STZ) induced diabetic rats. MATERIALS AND METHODS: Type 2 diabetes was induced in 140 rats by feeding with HFD and high sugar water for 6 weeks and single injection of STZ (30mg/kg, intraperitoneally). CP ethanol extract (CPEE) and aqueous extract (CPAE) at three doses at 2, 4 and 8 g/kg/day were orally administered once daily for four weeks. Blood glucose, serum insulin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), free fatty acid (FFA), total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), blood urea nitrogen (BUN), creatinine (CREA) and glycated serum protein (GSP) were examined. The content of total flavonoids and polysaccharides in CPEE and CPAE were assayed by ultraviolet spectrophotometry. RESULTS: Both CPEE and CPAE increased OGTT, ITT, HDL-C, SOD and GSH-Px, while they decreased FFA, TC, TG, LDL-C, MDA, BUN, CREA and GSP. The amount of total flavonoids was found in CPEE (30.41 mg/g extract), followed by CPAE (6.75 mg/g extract). Similarly, the polysaccharides content (4.13 mg/g extract) was observed in CPAE, while absent in CPEE. CONCLUSIONS: The results suggested that CPEE and CPAE exhibited the similar antihyperglycemic, antihyperlipidemic and antioxidant effects in type 2 diabetic rats, and there were no significant differences between these two extracts. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/24184190/Antihyperglycemic_antihyperlipidemic_and_antioxidant_effects_of_ethanol_and_aqueous_extracts_of_Cyclocarya_paliurus_leaves_in_type_2_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00747-2 DB - PRIME DP - Unbound Medicine ER -