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Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats.

Abstract

Depression is one of the most common neuropsychiatric disorders and has been associated with impaired cognition, as well as causing neuroendocrine systems and brain proteins alterations. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressant-like effects. The aim of this study was to determine whether resveratrol administration influences chronic unpredictable mild stress (CUMS)-induced cognitive deficits and explores underlying mechanisms. The results showed that CUMS (5weeks) was effective in producing cognitive deficits in rats as indicated by Morris water maze and novel object recognition task. Additionally, CUMS exposure significantly elevated serum corticosterone levels and decreased BDNF levels in the prefrontal cortex (PFC) and hippocampus, accompanied by decreased phosphorylation of extracellular signal-regulated kinase (pERK) and cAMP response element-binding protein (pCREB). Chronic administration of resveratrol (80mg/kg, i.p., 5weeks) significantly prevented all these CUMS-induced behavioral and biochemical alterations. In conclusion, our study shows that resveratrol may be an effective therapeutic agent for cognitive disturbances as was seen within the stress model and its neuroprotective effect was mediated in part by normalizing serum corticosterone levels, up-regulating of the BDNF, pCREB and pERK levels.

Authors+Show Affiliations

Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Bioscience, Luoyang Normal University, 71#, Longmen Road, Luoyang, Henan 471022, PR China; Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Institute of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: wangzhen@sdu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24184538

Citation

Liu, Dexiang, et al. "Resveratrol Prevents Impaired Cognition Induced By Chronic Unpredictable Mild Stress in Rats." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 49, 2014, pp. 21-9.
Liu D, Zhang Q, Gu J, et al. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014;49:21-9.
Liu, D., Zhang, Q., Gu, J., Wang, X., Xie, K., Xian, X., Wang, J., Jiang, H., & Wang, Z. (2014). Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Progress in Neuro-psychopharmacology & Biological Psychiatry, 49, 21-9. https://doi.org/10.1016/j.pnpbp.2013.10.017
Liu D, et al. Resveratrol Prevents Impaired Cognition Induced By Chronic Unpredictable Mild Stress in Rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:21-9. PubMed PMID: 24184538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. AU - Liu,Dexiang, AU - Zhang,Qingrui, AU - Gu,Jianhua, AU - Wang,Xueer, AU - Xie,Kai, AU - Xian,Xiuying, AU - Wang,Jianmei, AU - Jiang,Hong, AU - Wang,Zhen, Y1 - 2013/10/31/ PY - 2013/08/30/received PY - 2013/10/16/revised PY - 2013/10/23/accepted PY - 2013/11/5/entrez PY - 2013/11/5/pubmed PY - 2015/1/1/medline KW - BDNF KW - Brain derived neurotrophic factor (BDNF) KW - CREB KW - CUMS KW - Chronic unpredictable mild stress (CUMS) KW - Cognitive deficits KW - ERK KW - HPA KW - MWM KW - Morris water maze KW - NORT KW - PFC KW - RT-PCR KW - Resveratrol KW - brain derived neurotrophic factor KW - cAMP response element-binding protein KW - chronic unpredictable mild stress KW - extracellular signal-regulated kinase KW - hypothalamic–pituitary–adrenal KW - novel object recognition task KW - prefrontal cortex KW - reverse transcription-polymerase chain reaction SP - 21 EP - 9 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 49 N2 - Depression is one of the most common neuropsychiatric disorders and has been associated with impaired cognition, as well as causing neuroendocrine systems and brain proteins alterations. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressant-like effects. The aim of this study was to determine whether resveratrol administration influences chronic unpredictable mild stress (CUMS)-induced cognitive deficits and explores underlying mechanisms. The results showed that CUMS (5weeks) was effective in producing cognitive deficits in rats as indicated by Morris water maze and novel object recognition task. Additionally, CUMS exposure significantly elevated serum corticosterone levels and decreased BDNF levels in the prefrontal cortex (PFC) and hippocampus, accompanied by decreased phosphorylation of extracellular signal-regulated kinase (pERK) and cAMP response element-binding protein (pCREB). Chronic administration of resveratrol (80mg/kg, i.p., 5weeks) significantly prevented all these CUMS-induced behavioral and biochemical alterations. In conclusion, our study shows that resveratrol may be an effective therapeutic agent for cognitive disturbances as was seen within the stress model and its neuroprotective effect was mediated in part by normalizing serum corticosterone levels, up-regulating of the BDNF, pCREB and pERK levels. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/24184538/Resveratrol_prevents_impaired_cognition_induced_by_chronic_unpredictable_mild_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(13)00238-8 DB - PRIME DP - Unbound Medicine ER -