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Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments.
Acta Psychiatr Scand Suppl. 1985; 325:3-31.AP

Abstract

The relationship between the ratio in plasma of tryptophan to competing amino acids, which indicates brain serotonin synthesis, and the clinical response in depressed patients to treatments that act by enhancing brain serotoninergic function has been studied. There was a significantly positive correlation between the pretreatment plasma tryptophan ratio and the final depression score in patients treated with L-tryptophan or amitriptyline, and a trend towards a positive correlation in patients treated with lithium plus L-tryptophan or clomipramine. Patients with a low plasma tryptophan ratio generally showed greater clinical improvement than patients with a high ratio. When the plasma tryptophan ratio and the ratio in plasma of tyrosine to competing amino acids were considered together there was also a significant relationship between clinical and biochemical findings in patients treated with imipramine. These studies strongly indicate that brain serotoninergic function can be disturbed in depressed patients and, thus, lend support to the serotonin deficiency hypothesis in depression. Evidence has furthermore been presented which suggests that, rather than a low brain serotonin level per se, the hypofunction may be associated with disturbances in adaptive and regulatory mechanisms, e.g. postsynaptic serotonin receptors.

Authors

No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

2418637

Citation

Møller, S E.. "Tryptophan to Competing Amino Acids Ratio in Depressive Disorder: Relation to Efficacy of Antidepressive Treatments." Acta Psychiatrica Scandinavica. Supplementum, vol. 325, 1985, pp. 3-31.
Møller SE. Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. Acta Psychiatr Scand Suppl. 1985;325:3-31.
Møller, S. E. (1985). Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. Acta Psychiatrica Scandinavica. Supplementum, 325, 3-31.
Møller SE. Tryptophan to Competing Amino Acids Ratio in Depressive Disorder: Relation to Efficacy of Antidepressive Treatments. Acta Psychiatr Scand Suppl. 1985;325:3-31. PubMed PMID: 2418637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. A1 - Møller,S E, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 3 EP - 31 JF - Acta psychiatrica Scandinavica. Supplementum JO - Acta Psychiatr Scand Suppl VL - 325 N2 - The relationship between the ratio in plasma of tryptophan to competing amino acids, which indicates brain serotonin synthesis, and the clinical response in depressed patients to treatments that act by enhancing brain serotoninergic function has been studied. There was a significantly positive correlation between the pretreatment plasma tryptophan ratio and the final depression score in patients treated with L-tryptophan or amitriptyline, and a trend towards a positive correlation in patients treated with lithium plus L-tryptophan or clomipramine. Patients with a low plasma tryptophan ratio generally showed greater clinical improvement than patients with a high ratio. When the plasma tryptophan ratio and the ratio in plasma of tyrosine to competing amino acids were considered together there was also a significant relationship between clinical and biochemical findings in patients treated with imipramine. These studies strongly indicate that brain serotoninergic function can be disturbed in depressed patients and, thus, lend support to the serotonin deficiency hypothesis in depression. Evidence has furthermore been presented which suggests that, rather than a low brain serotonin level per se, the hypofunction may be associated with disturbances in adaptive and regulatory mechanisms, e.g. postsynaptic serotonin receptors. SN - 0065-1591 UR - https://www.unboundmedicine.com/medline/citation/2418637/Tryptophan_to_competing_amino_acids_ratio_in_depressive_disorder:_relation_to_efficacy_of_antidepressive_treatments_ L2 - https://medlineplus.gov/antidepressants.html DB - PRIME DP - Unbound Medicine ER -