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Ankylosing spondylitis and nonradiographic axial spondyloarthritis: part of a common spectrum or distinct diseases?
J Rheumatol. 2013 Dec; 40(12):2038-41.JR

Abstract

OBJECTIVE

To investigate the features of ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-axSpA) in a Canadian cohort of 639 patients with AS and 73 patients with nr-axSpA.

METHODS

Clinical and laboratory data were compared for patients with AS and nr-axSpA enrolled in a longitudinal SpA cohort.

RESULTS

The proportion of male patients was higher in AS than in nr-axSpA (76.2% vs 47.9%; p < 0.0001). There was no difference in the presence of HLA-B27 between AS (78.9%) and nr-axSpA (72.5%) patients, nor in age at the time of diagnosis, although AS patients were younger at the time of symptom onset (23.9 yrs vs 26.4 yrs; p = 0.03). Disease duration at the time of last clinic visit was longer for AS than for nr-axSpA patients (17.7 yrs vs 12.1 yrs; p = 0.0002). Acute-phase reactants were higher in AS than in nr-axSpA (C-reactive protein 11.4 vs 5.2, p < 0.0001; erythrocyte sedimentation rate 13.7 vs 9.9, p = 0.02). The Bath Ankylosing Spondylitis Metrology Index was higher in patients with AS (2.84 vs 1.35, p < 0.0001).

CONCLUSION

Patients with nr-axSpA were more likely to be female and to have lower inflammatory markers than patients with AS. When restricted to female patients only, acute-phase reactants did not differ significantly between AS and nr-axSpA. The evidence provides indirect support for the concept that nr-axSpA may represent an early form of AS, but that also has features of a distinct disease entity with significant burden of symptoms.

Authors+Show Affiliations

From the Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24187102

Citation

Wallis, Dinny, et al. "Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Part of a Common Spectrum or Distinct Diseases?" The Journal of Rheumatology, vol. 40, no. 12, 2013, pp. 2038-41.
Wallis D, Haroon N, Ayearst R, et al. Ankylosing spondylitis and nonradiographic axial spondyloarthritis: part of a common spectrum or distinct diseases? J Rheumatol. 2013;40(12):2038-41.
Wallis, D., Haroon, N., Ayearst, R., Carty, A., & Inman, R. D. (2013). Ankylosing spondylitis and nonradiographic axial spondyloarthritis: part of a common spectrum or distinct diseases? The Journal of Rheumatology, 40(12), 2038-41. https://doi.org/10.3899/jrheum.130588
Wallis D, et al. Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Part of a Common Spectrum or Distinct Diseases. J Rheumatol. 2013;40(12):2038-41. PubMed PMID: 24187102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ankylosing spondylitis and nonradiographic axial spondyloarthritis: part of a common spectrum or distinct diseases? AU - Wallis,Dinny, AU - Haroon,Nigil, AU - Ayearst,Renise, AU - Carty,Adele, AU - Inman,Robert D, Y1 - 2013/11/01/ PY - 2013/11/5/entrez PY - 2013/11/5/pubmed PY - 2014/8/13/medline KW - ANKYLOSING SPONDYLITIS KW - AXIAL SPONDYLOARTHRITIS SP - 2038 EP - 41 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 40 IS - 12 N2 - OBJECTIVE: To investigate the features of ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-axSpA) in a Canadian cohort of 639 patients with AS and 73 patients with nr-axSpA. METHODS: Clinical and laboratory data were compared for patients with AS and nr-axSpA enrolled in a longitudinal SpA cohort. RESULTS: The proportion of male patients was higher in AS than in nr-axSpA (76.2% vs 47.9%; p < 0.0001). There was no difference in the presence of HLA-B27 between AS (78.9%) and nr-axSpA (72.5%) patients, nor in age at the time of diagnosis, although AS patients were younger at the time of symptom onset (23.9 yrs vs 26.4 yrs; p = 0.03). Disease duration at the time of last clinic visit was longer for AS than for nr-axSpA patients (17.7 yrs vs 12.1 yrs; p = 0.0002). Acute-phase reactants were higher in AS than in nr-axSpA (C-reactive protein 11.4 vs 5.2, p < 0.0001; erythrocyte sedimentation rate 13.7 vs 9.9, p = 0.02). The Bath Ankylosing Spondylitis Metrology Index was higher in patients with AS (2.84 vs 1.35, p < 0.0001). CONCLUSION: Patients with nr-axSpA were more likely to be female and to have lower inflammatory markers than patients with AS. When restricted to female patients only, acute-phase reactants did not differ significantly between AS and nr-axSpA. The evidence provides indirect support for the concept that nr-axSpA may represent an early form of AS, but that also has features of a distinct disease entity with significant burden of symptoms. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/24187102/Ankylosing_spondylitis_and_nonradiographic_axial_spondyloarthritis:_part_of_a_common_spectrum_or_distinct_diseases L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=24187102 DB - PRIME DP - Unbound Medicine ER -