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High incidence of lead poisoning revealed by erythrocyte protoporphyrin (EPP) screening in Arabian children.
Ann Trop Paediatr. 1985 Dec; 5(4):207-10.AT

Abstract

The measurement of erythrocyte protoporphyrin (EPP) has been used in screening infants for undue exposure to lead. The infants were from a high risk area, Al Jahra in Kuwait, and were selected from those attending the emergency department of Al Jahra District Hospital. Dried spots of blood on Guthrie filter paper were mailed to the Central Laboratory of the Children's Hospital in Buffalo, New York. Elevated EPP values (greater than 50 micrograms/dl) were present in 63 (66%) out of 96 tests. Forty-four of the infants with elevated values were investigated further: 16 had blood lead levels above 30 micrograms/dl (1.45 mmol/l) and 12 had evidence of iron deficiency anaemia. Five infants with blood lead levels above 80 micrograms/dl (3.9 mmol/l) needed urgent chelation and in addition an 8-month-old infant with the highest EPP value (478 micrograms/dl) died of acute lead encephalopathy. We conclude that lead poisoning is a serious problem in Al Jahra, Kuwait, and that a comprehensive programme for screening and health education are urgently needed to avoid the irreversible effects of lead toxicity.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

2418770

Citation

Shaltout, A A., et al. "High Incidence of Lead Poisoning Revealed By Erythrocyte Protoporphyrin (EPP) Screening in Arabian Children." Annals of Tropical Paediatrics, vol. 5, no. 4, 1985, pp. 207-10.
Shaltout AA, Ghawaby MM, Hassan MF, et al. High incidence of lead poisoning revealed by erythrocyte protoporphyrin (EPP) screening in Arabian children. Ann Trop Paediatr. 1985;5(4):207-10.
Shaltout, A. A., Ghawaby, M. M., Hassan, M. F., Hunt, M. C., Fernando, N., Devarajan, L. V., Kollberg, H., & Guthrie, R. (1985). High incidence of lead poisoning revealed by erythrocyte protoporphyrin (EPP) screening in Arabian children. Annals of Tropical Paediatrics, 5(4), 207-10.
Shaltout AA, et al. High Incidence of Lead Poisoning Revealed By Erythrocyte Protoporphyrin (EPP) Screening in Arabian Children. Ann Trop Paediatr. 1985;5(4):207-10. PubMed PMID: 2418770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High incidence of lead poisoning revealed by erythrocyte protoporphyrin (EPP) screening in Arabian children. AU - Shaltout,A A, AU - Ghawaby,M M, AU - Hassan,M F, AU - Hunt,M C, AU - Fernando,N, AU - Devarajan,L V, AU - Kollberg,H, AU - Guthrie,R, PY - 1985/12/1/pubmed PY - 1985/12/1/medline PY - 1985/12/1/entrez SP - 207 EP - 10 JF - Annals of tropical paediatrics JO - Ann Trop Paediatr VL - 5 IS - 4 N2 - The measurement of erythrocyte protoporphyrin (EPP) has been used in screening infants for undue exposure to lead. The infants were from a high risk area, Al Jahra in Kuwait, and were selected from those attending the emergency department of Al Jahra District Hospital. Dried spots of blood on Guthrie filter paper were mailed to the Central Laboratory of the Children's Hospital in Buffalo, New York. Elevated EPP values (greater than 50 micrograms/dl) were present in 63 (66%) out of 96 tests. Forty-four of the infants with elevated values were investigated further: 16 had blood lead levels above 30 micrograms/dl (1.45 mmol/l) and 12 had evidence of iron deficiency anaemia. Five infants with blood lead levels above 80 micrograms/dl (3.9 mmol/l) needed urgent chelation and in addition an 8-month-old infant with the highest EPP value (478 micrograms/dl) died of acute lead encephalopathy. We conclude that lead poisoning is a serious problem in Al Jahra, Kuwait, and that a comprehensive programme for screening and health education are urgently needed to avoid the irreversible effects of lead toxicity. SN - 0272-4936 UR - https://www.unboundmedicine.com/medline/citation/2418770/High_incidence_of_lead_poisoning_revealed_by_erythrocyte_protoporphyrin__EPP__screening_in_Arabian_children_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -