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Electrospun fibers for vaginal anti-HIV drug delivery.
Antiviral Res. 2013 Dec; 100 Suppl:S9-16.AR

Abstract

Diversity of microbicide delivery systems is essential for future success in the prevention and treatment of HIV in order to account for the varied populations of women all over the world that may benefit from use of these products. Recently, a novel dosage form for intravaginal drug delivery has been developed using drug-eluting fibers fabricated by electrospinning. There is a strong rationale to support the idea that drug-eluting fibers can be designed to realize multiple design constraints in a single product for topical HIV prevention: fibers are able to deliver a wide range of agents, incorporate multiple agents via composites, and facilitate controlled release over relevant time frames for pericoital and sustained (coitally-independent) use. It is also technologically feasible to scale-up production of fiber-based microbicides. Electrospun fibers may allow for prioritization of physical attributes that affect user perceptions without compromising biological efficacy. Challenges with using fibers as a microbicide include issues related to vehicle deployment, spreading and retention in the vaginal vault. In addition, studies will need to address the interaction of the fibers with the mucosal environment, including unknown safety and toxicity. Sustained release fiber microbicides capable of delivering multiple antiretroviral drugs while simultaneously exhibiting tunable degradation or dissolution of the fibers is also a challenge. However, electrospun fibers are a promising new platform for vaginal delivery of anti-HIV agents and future research will inform their place in the field. This article is based on a presentation at the "Product Development Workshop 2013: HIV and Multipurpose Prevention Technologies", held in Arlington, Virginia on February 20-21, 2013. It forms part of a special supplement to Antiviral Research.

Authors+Show Affiliations

Department of Bioengineering, University of Washington, Seattle, Washington, United States.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24188701

Citation

Blakney, Anna K., et al. "Electrospun Fibers for Vaginal anti-HIV Drug Delivery." Antiviral Research, vol. 100 Suppl, 2013, pp. S9-16.
Blakney AK, Ball C, Krogstad EA, et al. Electrospun fibers for vaginal anti-HIV drug delivery. Antiviral Res. 2013;100 Suppl:S9-16.
Blakney, A. K., Ball, C., Krogstad, E. A., & Woodrow, K. A. (2013). Electrospun fibers for vaginal anti-HIV drug delivery. Antiviral Research, 100 Suppl, S9-16. https://doi.org/10.1016/j.antiviral.2013.09.022
Blakney AK, et al. Electrospun Fibers for Vaginal anti-HIV Drug Delivery. Antiviral Res. 2013;100 Suppl:S9-16. PubMed PMID: 24188701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrospun fibers for vaginal anti-HIV drug delivery. AU - Blakney,Anna K, AU - Ball,Cameron, AU - Krogstad,Emily A, AU - Woodrow,Kim A, Y1 - 2013/11/01/ PY - 2013/06/21/received PY - 2013/09/19/revised PY - 2013/09/26/accepted PY - 2013/11/6/entrez PY - 2013/11/6/pubmed PY - 2014/7/16/medline KW - Antiretroviral KW - Electrospun fibers KW - Human immunodeficiency virus KW - Microbicide KW - Vaginal delivery SP - S9 EP - 16 JF - Antiviral research JO - Antiviral Res VL - 100 Suppl N2 - Diversity of microbicide delivery systems is essential for future success in the prevention and treatment of HIV in order to account for the varied populations of women all over the world that may benefit from use of these products. Recently, a novel dosage form for intravaginal drug delivery has been developed using drug-eluting fibers fabricated by electrospinning. There is a strong rationale to support the idea that drug-eluting fibers can be designed to realize multiple design constraints in a single product for topical HIV prevention: fibers are able to deliver a wide range of agents, incorporate multiple agents via composites, and facilitate controlled release over relevant time frames for pericoital and sustained (coitally-independent) use. It is also technologically feasible to scale-up production of fiber-based microbicides. Electrospun fibers may allow for prioritization of physical attributes that affect user perceptions without compromising biological efficacy. Challenges with using fibers as a microbicide include issues related to vehicle deployment, spreading and retention in the vaginal vault. In addition, studies will need to address the interaction of the fibers with the mucosal environment, including unknown safety and toxicity. Sustained release fiber microbicides capable of delivering multiple antiretroviral drugs while simultaneously exhibiting tunable degradation or dissolution of the fibers is also a challenge. However, electrospun fibers are a promising new platform for vaginal delivery of anti-HIV agents and future research will inform their place in the field. This article is based on a presentation at the "Product Development Workshop 2013: HIV and Multipurpose Prevention Technologies", held in Arlington, Virginia on February 20-21, 2013. It forms part of a special supplement to Antiviral Research. SN - 1872-9096 UR - https://www.unboundmedicine.com/medline/citation/24188701/Electrospun_fibers_for_vaginal_anti_HIV_drug_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-3542(13)00282-9 DB - PRIME DP - Unbound Medicine ER -