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A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.
Annu Rev Physiol. 2014; 76:225-49.AR

Abstract

Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including insulin resistance. Much progress has been made, particularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose cell fate, and hormonal control of BAT thermogenesis. As we enter into a new era of brown fat biology, the next challenge will be to develop strategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure. This article reviews the recent major advances in this field and discusses emerging questions.

Authors+Show Affiliations

Diabetes Center, Department of Cell and Tissue Biology, University of California, San Francisco, California 94143-0669; email: skajimura@diabetes.ucsf.edu.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24188710

Citation

Kajimura, Shingo, and Masayuki Saito. "A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis." Annual Review of Physiology, vol. 76, 2014, pp. 225-49.
Kajimura S, Saito M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol. 2014;76:225-49.
Kajimura, S., & Saito, M. (2014). A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annual Review of Physiology, 76, 225-49. https://doi.org/10.1146/annurev-physiol-021113-170252
Kajimura S, Saito M. A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis. Annu Rev Physiol. 2014;76:225-49. PubMed PMID: 24188710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. AU - Kajimura,Shingo, AU - Saito,Masayuki, Y1 - 2013/11/04/ PY - 2013/11/6/entrez PY - 2013/11/6/pubmed PY - 2014/10/1/medline SP - 225 EP - 49 JF - Annual review of physiology JO - Annu. Rev. Physiol. VL - 76 N2 - Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including insulin resistance. Much progress has been made, particularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose cell fate, and hormonal control of BAT thermogenesis. As we enter into a new era of brown fat biology, the next challenge will be to develop strategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure. This article reviews the recent major advances in this field and discusses emerging questions. SN - 1545-1585 UR - https://www.unboundmedicine.com/medline/citation/24188710/A_new_era_in_brown_adipose_tissue_biology:_molecular_control_of_brown_fat_development_and_energy_homeostasis_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-physiol-021113-170252?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -