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Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon.
J Trace Elem Med Biol. 2014 Jan; 28(1):89-93.JT

Abstract

Diazinon (DZN) is one of the most organophosphate insecticides that widely used in agriculture and industry. Selenium is generally recognized to be a trace mineral of great importance for human health, protecting the cells from the harmful effects of free radicals. Therefore, the present study was carried out to investigate the alterations in biochemical parameters, free radicals and enzyme activities induced by diazinon in male rat serum, and the role of selenium in alleviating the negative effects of DZN. Animals were divided into four groups of seven rats each; the first group was used as control. Groups 2, 3 and 4 were treated with selenium (Se; 200μg/kg BW), diazinon (DZN; 10mg/kg BW) and diazinon plus selenium, respectively. Rats were orally administered their respective doses daily for 30 days. Results obtained showed that DZN significantly induced thiobarbituric acid reactive substances (TBARS) and decreased the activities of glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) and the levels of reduced glutathione (GSH) in rat sera. Aminotransferases (AST, ALT), phosphatases (AlP, AcP) and lactate dehydrogenase (LDH) activities were significantly increased while acetylcholinesterase (AChE) activity was decreased due to DZN administration. Also, DZN treatment caused significant perturbations in lipids profile and serum biochemical parameters. On the other hand, Se alone significantly decreased the levels of TBARS, total lipids, cholesterol, urea and creatinine, while increased the activities of antioxidant enzymes and glutathione content, total protein (TP) and albumin. In addition, Se in combination with DZN partially or totally alleviated its toxic effects on the studied parameters. In conclusion, Se has beneficial effects and could be able to antagonize DZN toxicity.

Authors+Show Affiliations

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt. Electronic address: eldemerdashf@yahoo.com.Department of Pest Control and Environmental Protection, Faculty of Agriculture, Damanhour University, Damanhour, Egypt. Electronic address: cohm_hm@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24188896

Citation

El-Demerdash, Fatma M., and Hoda M. Nasr. "Antioxidant Effect of Selenium On Lipid Peroxidation, Hyperlipidemia and Biochemical Parameters in Rats Exposed to Diazinon." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 28, no. 1, 2014, pp. 89-93.
El-Demerdash FM, Nasr HM. Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. J Trace Elem Med Biol. 2014;28(1):89-93.
El-Demerdash, F. M., & Nasr, H. M. (2014). Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 28(1), 89-93. https://doi.org/10.1016/j.jtemb.2013.10.001
El-Demerdash FM, Nasr HM. Antioxidant Effect of Selenium On Lipid Peroxidation, Hyperlipidemia and Biochemical Parameters in Rats Exposed to Diazinon. J Trace Elem Med Biol. 2014;28(1):89-93. PubMed PMID: 24188896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. AU - El-Demerdash,Fatma M, AU - Nasr,Hoda M, Y1 - 2013/10/16/ PY - 2013/06/16/received PY - 2013/10/03/revised PY - 2013/10/04/accepted PY - 2013/11/6/entrez PY - 2013/11/6/pubmed PY - 2014/9/11/medline KW - Diazinon KW - Enzymes KW - Lipids profile KW - Oxidative stress KW - Selenium SP - 89 EP - 93 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 28 IS - 1 N2 - Diazinon (DZN) is one of the most organophosphate insecticides that widely used in agriculture and industry. Selenium is generally recognized to be a trace mineral of great importance for human health, protecting the cells from the harmful effects of free radicals. Therefore, the present study was carried out to investigate the alterations in biochemical parameters, free radicals and enzyme activities induced by diazinon in male rat serum, and the role of selenium in alleviating the negative effects of DZN. Animals were divided into four groups of seven rats each; the first group was used as control. Groups 2, 3 and 4 were treated with selenium (Se; 200μg/kg BW), diazinon (DZN; 10mg/kg BW) and diazinon plus selenium, respectively. Rats were orally administered their respective doses daily for 30 days. Results obtained showed that DZN significantly induced thiobarbituric acid reactive substances (TBARS) and decreased the activities of glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) and the levels of reduced glutathione (GSH) in rat sera. Aminotransferases (AST, ALT), phosphatases (AlP, AcP) and lactate dehydrogenase (LDH) activities were significantly increased while acetylcholinesterase (AChE) activity was decreased due to DZN administration. Also, DZN treatment caused significant perturbations in lipids profile and serum biochemical parameters. On the other hand, Se alone significantly decreased the levels of TBARS, total lipids, cholesterol, urea and creatinine, while increased the activities of antioxidant enzymes and glutathione content, total protein (TP) and albumin. In addition, Se in combination with DZN partially or totally alleviated its toxic effects on the studied parameters. In conclusion, Se has beneficial effects and could be able to antagonize DZN toxicity. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/24188896/Antioxidant_effect_of_selenium_on_lipid_peroxidation_hyperlipidemia_and_biochemical_parameters_in_rats_exposed_to_diazinon_ DB - PRIME DP - Unbound Medicine ER -