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Anti-inflammatory and pharmacokinetics evaluation of PEGylated ibuprofen tablet formulation.
Drug Deliv. 2014 Jun; 21(4):315-9.DD

Abstract

To develop a novel PEGylated ibuprofen tablet formulations and evaluate its anti-inflammatory activity and pharmacokinetics profile in an animal model. Six batches of PEGylated ibuprofen tablets were prepared by direct compression using Avicel® and lactose as the binder diluents. In vivo anti-inflammatory activity of the tablets was carried out as well as the pharmacokinetics profiles. The PEGylated ibuprofen tablet reduced carrageenan-induced inflammation in experimental animals and sustained its anti-inflammatory action for over 10 h. The pharmacokinetics profile of the optimized formulations were greater than that of the marketed sample and the pure drug sample. In conclusion, PEGylation of ibuprofen conferred a high level of anti-inflammatory activity and slowed plasma clearance level, indicating sustained release. Thus, further exploration of this novel formulation to be used as an alternative carrier for this drug is required.

Authors+Show Affiliations

Drug Delivery Research Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria , Nsukka .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24191762

Citation

Mumuni, Momoh A., et al. "Anti-inflammatory and Pharmacokinetics Evaluation of PEGylated Ibuprofen Tablet Formulation." Drug Delivery, vol. 21, no. 4, 2014, pp. 315-9.
Mumuni M, Kenechukwu FC, Chime SA, et al. Anti-inflammatory and pharmacokinetics evaluation of PEGylated ibuprofen tablet formulation. Drug Deliv. 2014;21(4):315-9.
Mumuni, M., Kenechukwu, F. C., Chime, S. A., Ogbonna, J. D., & Mora, A. T. (2014). Anti-inflammatory and pharmacokinetics evaluation of PEGylated ibuprofen tablet formulation. Drug Delivery, 21(4), 315-9. https://doi.org/10.3109/10717544.2013.850759
Mumuni M, et al. Anti-inflammatory and Pharmacokinetics Evaluation of PEGylated Ibuprofen Tablet Formulation. Drug Deliv. 2014;21(4):315-9. PubMed PMID: 24191762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and pharmacokinetics evaluation of PEGylated ibuprofen tablet formulation. AU - Mumuni,Momoh A, AU - Kenechukwu,Franklin Chimaobi, AU - Chime,Salome Amarachi, AU - Ogbonna,John Dike, AU - Mora,A T, Y1 - 2013/11/05/ PY - 2013/11/7/entrez PY - 2013/11/7/pubmed PY - 2015/1/27/medline KW - Ibuprofen KW - PEGylation KW - pharmacokinetics KW - sustained release KW - tablets SP - 315 EP - 9 JF - Drug delivery JO - Drug Deliv VL - 21 IS - 4 N2 - To develop a novel PEGylated ibuprofen tablet formulations and evaluate its anti-inflammatory activity and pharmacokinetics profile in an animal model. Six batches of PEGylated ibuprofen tablets were prepared by direct compression using Avicel® and lactose as the binder diluents. In vivo anti-inflammatory activity of the tablets was carried out as well as the pharmacokinetics profiles. The PEGylated ibuprofen tablet reduced carrageenan-induced inflammation in experimental animals and sustained its anti-inflammatory action for over 10 h. The pharmacokinetics profile of the optimized formulations were greater than that of the marketed sample and the pure drug sample. In conclusion, PEGylation of ibuprofen conferred a high level of anti-inflammatory activity and slowed plasma clearance level, indicating sustained release. Thus, further exploration of this novel formulation to be used as an alternative carrier for this drug is required. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/24191762/Anti_inflammatory_and_pharmacokinetics_evaluation_of_PEGylated_ibuprofen_tablet_formulation_ L2 - https://www.tandfonline.com/doi/full/10.3109/10717544.2013.850759 DB - PRIME DP - Unbound Medicine ER -