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Brain on fire: anti-N-methyl-D-aspartate-receptor encephalitis associated with ovarian teratoma.
Conn Med. 2013 Aug; 77(7):389-92.CM

Abstract

INTRODUCTION

Anti-N-methyl-D-aspartate-receptor (anti-NMDAR) encephalitis is the most common antibody-defined autoimmune neuronal disorder. It may present with psychiatric symptoms, decreased consciousness, and hypoventilation.

DATA SOURCES

A 33-year old female presented with agitation and psychotic symptoms following a flu-like illness. She was treated for a presumed psychiatric disorder before she developed seizures and respiratory failure. An extensive workup including routine blood work, brain imagining, electroencephalography, and cerebrospinal fluid analysis was unremarkable. After a prolonged hospital stay requiring multiple antiepileptic drugs and sedatives, a computerized tomography of the abdomen revealed an ovarian tumor. Immunosuppressive therapy was initiated and the tumor was resected, when anti-NMDAR encephalitis was suspected. The diagnosis was confirmed following a positive anti-NMDAR antibody.

CONCLUSION

Anti-NMDAR encephalitis should be considered in the differential diagnosis of a diverse array of conditions. This case report emphasizes the importance of investigating such patients since proper treatment could potentially prevent neurologic complications or death.

Authors+Show Affiliations

Department of Internal Medicine, University of Connecticut School of Medicine, Farmington, USA. smaraka@resident.uchc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24195175

Citation

Maraka, Spyridoula, et al. "Brain On Fire: anti-N-methyl-D-aspartate-receptor Encephalitis Associated With Ovarian Teratoma." Connecticut Medicine, vol. 77, no. 7, 2013, pp. 389-92.
Maraka S, Bulathsinghala CP, Grover P. Brain on fire: anti-N-methyl-D-aspartate-receptor encephalitis associated with ovarian teratoma. Conn Med. 2013;77(7):389-92.
Maraka, S., Bulathsinghala, C. P., & Grover, P. (2013). Brain on fire: anti-N-methyl-D-aspartate-receptor encephalitis associated with ovarian teratoma. Connecticut Medicine, 77(7), 389-92.
Maraka S, Bulathsinghala CP, Grover P. Brain On Fire: anti-N-methyl-D-aspartate-receptor Encephalitis Associated With Ovarian Teratoma. Conn Med. 2013;77(7):389-92. PubMed PMID: 24195175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain on fire: anti-N-methyl-D-aspartate-receptor encephalitis associated with ovarian teratoma. AU - Maraka,Spyridoula, AU - Bulathsinghala,Chinthaka P, AU - Grover,Prasant, PY - 2013/11/8/entrez PY - 2013/11/8/pubmed PY - 2013/12/18/medline SP - 389 EP - 92 JF - Connecticut medicine JO - Conn Med VL - 77 IS - 7 N2 - INTRODUCTION: Anti-N-methyl-D-aspartate-receptor (anti-NMDAR) encephalitis is the most common antibody-defined autoimmune neuronal disorder. It may present with psychiatric symptoms, decreased consciousness, and hypoventilation. DATA SOURCES: A 33-year old female presented with agitation and psychotic symptoms following a flu-like illness. She was treated for a presumed psychiatric disorder before she developed seizures and respiratory failure. An extensive workup including routine blood work, brain imagining, electroencephalography, and cerebrospinal fluid analysis was unremarkable. After a prolonged hospital stay requiring multiple antiepileptic drugs and sedatives, a computerized tomography of the abdomen revealed an ovarian tumor. Immunosuppressive therapy was initiated and the tumor was resected, when anti-NMDAR encephalitis was suspected. The diagnosis was confirmed following a positive anti-NMDAR antibody. CONCLUSION: Anti-NMDAR encephalitis should be considered in the differential diagnosis of a diverse array of conditions. This case report emphasizes the importance of investigating such patients since proper treatment could potentially prevent neurologic complications or death. SN - 0010-6178 UR - https://www.unboundmedicine.com/medline/citation/24195175/Brain_on_fire:_anti_N_methyl_D_aspartate_receptor_encephalitis_associated_with_ovarian_teratoma_ L2 - http://www.diseaseinfosearch.org/result/7028 DB - PRIME DP - Unbound Medicine ER -
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