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Comparing the effects of meal replacements with reduced-fat diet on weight, sexual and endothelial function, testosterone and quality of life in obese Asian men.

Abstract

Sexual dysfunction is more prevalent in obese than in normal-weight men. Meal replacements (MRs) are useful weight-loss strategies. We randomized obese (body mass index 27.5 kg m(-2), waist circumference (WC) 90 cm) Asian men (mean age 40.5 years, range 30-61) to a conventional reduced-fat diet (CD) (n=24) or MR-based plan (n=24) to reduce daily intake by 400 kcal for 12 weeks. There were significantly greater reductions in weight (4.2 ± 0.8 kg), WC (4.6 ± 0.7 cm), calorie and fat intake in the MR group, compared with the CD group (2.5 ± 0.4 kg, 2.6 ± 0.5 cm). Erectile function (International Index of Erectile Function 5-item score) improved comparably in the MR (3.4 ± 0.7 points) and CD (2.5 ± 0.5 points) groups, as did the Sexual Desire Inventory score (5.5 ± 2.3 vs 7.7 ± 2.1 points), quality of life (36-item Short Form survey score), plasma testosterone and endothelial function (Reactive Hyperemia Index). Subjects were switched to or continued CD for another 28 weeks. Weight, WC and erectile function were maintained at 40 weeks. MR induces greater reductions in weight and abdominal obesity than conventional diet, and comparable improvements in sexual and endothelial function, testosterone and quality of life.

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  • Authors+Show Affiliations

    ,

    Department of Endocrinology, Changi General Hospital, Singapore, Singapore.

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    Department of Dietetic and Food Services, Changi General Hospital, Singapore, Singapore.

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    Department of Dietetic and Food Services, Changi General Hospital, Singapore, Singapore.

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    Department of Dietetic and Food Services, Changi General Hospital, Singapore, Singapore.

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    Department of Dietetic and Food Services, Changi General Hospital, Singapore, Singapore.

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    Department of Endocrinology, Changi General Hospital, Singapore, Singapore.

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    Department of Endocrinology, Changi General Hospital, Singapore, Singapore.

    ,

    Department of Endocrinology, Changi General Hospital, Singapore, Singapore.

    Department of Dietetic and Food Services, Changi General Hospital, Singapore, Singapore.

    Source

    MeSH

    Adult
    Aged
    Asian Continental Ancestry Group
    Blood Pressure
    Caloric Restriction
    Diet, Fat-Restricted
    Endothelium, Vascular
    Erectile Dysfunction
    Exercise
    Humans
    Insulin Resistance
    Male
    Middle Aged
    Obesity
    Quality of Life
    Sexual Behavior
    Testosterone
    Weight Loss

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24196274

    Citation

    Khoo, J, et al. "Comparing the Effects of Meal Replacements With Reduced-fat Diet On Weight, Sexual and Endothelial Function, Testosterone and Quality of Life in Obese Asian Men." International Journal of Impotence Research, vol. 26, no. 2, 2014, pp. 61-6.
    Khoo J, Ling PS, Tan J, et al. Comparing the effects of meal replacements with reduced-fat diet on weight, sexual and endothelial function, testosterone and quality of life in obese Asian men. Int J Impot Res. 2014;26(2):61-6.
    Khoo, J., Ling, P. S., Tan, J., Teo, A., Ng, H. L., Chen, R. Y., ... Cheong, M. (2014). Comparing the effects of meal replacements with reduced-fat diet on weight, sexual and endothelial function, testosterone and quality of life in obese Asian men. International Journal of Impotence Research, 26(2), pp. 61-6. doi:10.1038/ijir.2013.36.
    Khoo J, et al. Comparing the Effects of Meal Replacements With Reduced-fat Diet On Weight, Sexual and Endothelial Function, Testosterone and Quality of Life in Obese Asian Men. Int J Impot Res. 2014;26(2):61-6. PubMed PMID: 24196274.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparing the effects of meal replacements with reduced-fat diet on weight, sexual and endothelial function, testosterone and quality of life in obese Asian men. AU - Khoo,J, AU - Ling,P-S, AU - Tan,J, AU - Teo,A, AU - Ng,H-L, AU - Chen,R Y-T, AU - Tay,T-L, AU - Tan,E, AU - Cheong,M, Y1 - 2013/11/07/ PY - 2013/04/05/received PY - 2013/08/23/revised PY - 2013/09/23/accepted PY - 2013/11/8/entrez PY - 2013/11/8/pubmed PY - 2014/11/15/medline SP - 61 EP - 6 JF - International journal of impotence research JO - Int. J. Impot. Res. VL - 26 IS - 2 N2 - Sexual dysfunction is more prevalent in obese than in normal-weight men. Meal replacements (MRs) are useful weight-loss strategies. We randomized obese (body mass index 27.5 kg m(-2), waist circumference (WC) 90 cm) Asian men (mean age 40.5 years, range 30-61) to a conventional reduced-fat diet (CD) (n=24) or MR-based plan (n=24) to reduce daily intake by 400 kcal for 12 weeks. There were significantly greater reductions in weight (4.2 ± 0.8 kg), WC (4.6 ± 0.7 cm), calorie and fat intake in the MR group, compared with the CD group (2.5 ± 0.4 kg, 2.6 ± 0.5 cm). Erectile function (International Index of Erectile Function 5-item score) improved comparably in the MR (3.4 ± 0.7 points) and CD (2.5 ± 0.5 points) groups, as did the Sexual Desire Inventory score (5.5 ± 2.3 vs 7.7 ± 2.1 points), quality of life (36-item Short Form survey score), plasma testosterone and endothelial function (Reactive Hyperemia Index). Subjects were switched to or continued CD for another 28 weeks. Weight, WC and erectile function were maintained at 40 weeks. MR induces greater reductions in weight and abdominal obesity than conventional diet, and comparable improvements in sexual and endothelial function, testosterone and quality of life. SN - 1476-5489 UR - https://www.unboundmedicine.com/medline/citation/24196274/full_citation L2 - http://dx.doi.org/10.1038/ijir.2013.36 DB - PRIME DP - Unbound Medicine ER -