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Antioxidant vitamins and magnesium and the risk of hearing loss in the US general population.

Abstract

BACKGROUND

The protective effects of antioxidant vitamins on hearing loss are well established in animal studies but in few human studies. Recent animal studies suggest that magnesium intake along with antioxidants may act in synergy to prevent hearing loss.

OBJECTIVE

We examined associations between intake of antioxidant vitamins (daily β-carotene and vitamins C and E) and magnesium and hearing thresholds and explored their joint effects in US adults.

DESIGN

We analyzed cross-sectional data from 2592 participants aged 20-69 y from NHANES 2001-2004. Hearing thresholds as pure tone averages (PTAs) at speech (0.5, 1, 2, and 4 kHz) and high frequencies (3, 4, and 6 kHz) were computed.

RESULTS

When examined individually, modeled as quartiles, and after adjustment for potential confounders, higher intakes of β-carotene, vitamin C, and magnesium were associated with lower (better) PTAs at both speech and high frequencies. High intakes of β-carotene or vitamin C combined with high magnesium compared with low intakes of both nutrients were significantly associated with lower (better) PTAs at high frequencies (-14.82%; 95% CI: -20.50% to -8.74% for β-carotene + magnesium and -10.72%; 95% CI: -16.57% to -4.45% for vitamin C + magnesium). The estimated joint effects were borderline significantly larger than the sums of the individual effects [high β-carotene/low magnesium (-4.98%) and low β-carotene/high magnesium (-0.80%), P-interaction = 0.08; high vitamin C/low magnesium (-1.33%) and low vitamin C/high magnesium (2.13%), P-interaction = 0.09].

CONCLUSION

Dietary intakes of antioxidants and magnesium are associated with lower risks of hearing loss.

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  • Authors+Show Affiliations

    ,

    Department of Preventive Medicine and Institute of Environmental Medicine, Seoul National University College of Medicine, Seoul, Korea (Y-HC); the Department of Otolaryngology, School of Medicine and Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI (JMM); the Department of Health Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA (KLT); the Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada (HH); and the Departments of Epidemiology and Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI (SKP).

    , , ,

    Source

    MeSH

    Adult
    Aged
    Antioxidants
    Ascorbic Acid
    Cross-Sectional Studies
    Dietary Supplements
    Dose-Response Relationship, Drug
    Female
    Hearing Loss
    Humans
    Linear Models
    Magnesium
    Male
    Middle Aged
    Nutrition Surveys
    Risk Factors
    Vitamin E
    Young Adult
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    24196403

    Citation

    Choi, Yoon-Hyeong, et al. "Antioxidant Vitamins and Magnesium and the Risk of Hearing Loss in the US General Population." The American Journal of Clinical Nutrition, vol. 99, no. 1, 2014, pp. 148-55.
    Choi YH, Miller JM, Tucker KL, et al. Antioxidant vitamins and magnesium and the risk of hearing loss in the US general population. Am J Clin Nutr. 2014;99(1):148-55.
    Choi, Y. H., Miller, J. M., Tucker, K. L., Hu, H., & Park, S. K. (2014). Antioxidant vitamins and magnesium and the risk of hearing loss in the US general population. The American Journal of Clinical Nutrition, 99(1), pp. 148-55. doi:10.3945/ajcn.113.068437.
    Choi YH, et al. Antioxidant Vitamins and Magnesium and the Risk of Hearing Loss in the US General Population. Am J Clin Nutr. 2014;99(1):148-55. PubMed PMID: 24196403.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant vitamins and magnesium and the risk of hearing loss in the US general population. AU - Choi,Yoon-Hyeong, AU - Miller,Josef M, AU - Tucker,Katherine L, AU - Hu,Howard, AU - Park,Sung Kyun, Y1 - 2013/11/06/ PY - 2013/11/8/entrez PY - 2013/11/8/pubmed PY - 2014/2/25/medline SP - 148 EP - 55 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 99 IS - 1 N2 - BACKGROUND: The protective effects of antioxidant vitamins on hearing loss are well established in animal studies but in few human studies. Recent animal studies suggest that magnesium intake along with antioxidants may act in synergy to prevent hearing loss. OBJECTIVE: We examined associations between intake of antioxidant vitamins (daily β-carotene and vitamins C and E) and magnesium and hearing thresholds and explored their joint effects in US adults. DESIGN: We analyzed cross-sectional data from 2592 participants aged 20-69 y from NHANES 2001-2004. Hearing thresholds as pure tone averages (PTAs) at speech (0.5, 1, 2, and 4 kHz) and high frequencies (3, 4, and 6 kHz) were computed. RESULTS: When examined individually, modeled as quartiles, and after adjustment for potential confounders, higher intakes of β-carotene, vitamin C, and magnesium were associated with lower (better) PTAs at both speech and high frequencies. High intakes of β-carotene or vitamin C combined with high magnesium compared with low intakes of both nutrients were significantly associated with lower (better) PTAs at high frequencies (-14.82%; 95% CI: -20.50% to -8.74% for β-carotene + magnesium and -10.72%; 95% CI: -16.57% to -4.45% for vitamin C + magnesium). The estimated joint effects were borderline significantly larger than the sums of the individual effects [high β-carotene/low magnesium (-4.98%) and low β-carotene/high magnesium (-0.80%), P-interaction = 0.08; high vitamin C/low magnesium (-1.33%) and low vitamin C/high magnesium (2.13%), P-interaction = 0.09]. CONCLUSION: Dietary intakes of antioxidants and magnesium are associated with lower risks of hearing loss. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24196403/Antioxidant_vitamins_and_magnesium_and_the_risk_of_hearing_loss_in_the_US_general_population_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.068437 DB - PRIME DP - Unbound Medicine ER -