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Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and 6 h post dose in patients with pulmonary tuberculosis.
Int J Tuberc Lung Dis. 2013 Dec; 17(12):1602-6.IJ

Abstract

BACKGROUND

Low concentrations of anti-tuberculosis drugs are related to drug resistance and treatment failure.

OBJECTIVE

To determine the prevalence of low plasma concentrations of anti-tuberculosis drugs.

METHODS

The study was performed among 60 pulmonary tuberculosis (TB) in-patients at a tertiary care university-affiliated hospital in Tehran, Iran. Drug samples were drawn 2 and 6 h post dose for isoniazid (INH), rifampicin (RMP) and pyrazinamide (PZA); related concentrations were determined using high-performance liquid chromatography. Plasma drug concentrations, duration of treatment, age, sex, liver enzyme levels, administered doses and smoking status were evaluated and recorded.

RESULTS

Among 60 patients recruited to the study, the mean (±SD) age was 54.2 (±20.9) years; 39 were female. The median peak plasma concentrations (C(max)) of INH, RMP and PZA were respectively 2.5, 4.0 and 43.6 μg/ml; 81% of the patients had drug plasma concentrations lower than the target ranges for at least one administered drug. Respectively 49.1%, 92.5% and 8.7% of the patients had low concentrations of INH, RMP and PZA.

CONCLUSION

The results indicate that RMP concentrations are below the reference range in most patients, while PZA is within the target range of the standard doses.

Authors+Show Affiliations

Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Tehran, Iran; Clinical Pharmacy Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24200276

Citation

Fahimi, F, et al. "Isoniazid, Rifampicin and Pyrazinamide Plasma Concentrations 2 and 6 H Post Dose in Patients With Pulmonary Tuberculosis." The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, vol. 17, no. 12, 2013, pp. 1602-6.
Fahimi F, Tabarsi P, Kobarfard F, et al. Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and 6 h post dose in patients with pulmonary tuberculosis. Int J Tuberc Lung Dis. 2013;17(12):1602-6.
Fahimi, F., Tabarsi, P., Kobarfard, F., Bozorg, B. D., Goodarzi, A., Dastan, F., Shahsavari, N., Emami, S., Habibi, M., & Salamzadeh, J. (2013). Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and 6 h post dose in patients with pulmonary tuberculosis. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, 17(12), 1602-6. https://doi.org/10.5588/ijtld.13.0019
Fahimi F, et al. Isoniazid, Rifampicin and Pyrazinamide Plasma Concentrations 2 and 6 H Post Dose in Patients With Pulmonary Tuberculosis. Int J Tuberc Lung Dis. 2013;17(12):1602-6. PubMed PMID: 24200276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and 6 h post dose in patients with pulmonary tuberculosis. AU - Fahimi,F, AU - Tabarsi,P, AU - Kobarfard,F, AU - Bozorg,B D, AU - Goodarzi,A, AU - Dastan,F, AU - Shahsavari,N, AU - Emami,S, AU - Habibi,M, AU - Salamzadeh,J, PY - 2013/11/9/entrez PY - 2013/11/10/pubmed PY - 2014/6/26/medline SP - 1602 EP - 6 JF - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JO - Int. J. Tuberc. Lung Dis. VL - 17 IS - 12 N2 - BACKGROUND: Low concentrations of anti-tuberculosis drugs are related to drug resistance and treatment failure. OBJECTIVE: To determine the prevalence of low plasma concentrations of anti-tuberculosis drugs. METHODS: The study was performed among 60 pulmonary tuberculosis (TB) in-patients at a tertiary care university-affiliated hospital in Tehran, Iran. Drug samples were drawn 2 and 6 h post dose for isoniazid (INH), rifampicin (RMP) and pyrazinamide (PZA); related concentrations were determined using high-performance liquid chromatography. Plasma drug concentrations, duration of treatment, age, sex, liver enzyme levels, administered doses and smoking status were evaluated and recorded. RESULTS: Among 60 patients recruited to the study, the mean (±SD) age was 54.2 (±20.9) years; 39 were female. The median peak plasma concentrations (C(max)) of INH, RMP and PZA were respectively 2.5, 4.0 and 43.6 μg/ml; 81% of the patients had drug plasma concentrations lower than the target ranges for at least one administered drug. Respectively 49.1%, 92.5% and 8.7% of the patients had low concentrations of INH, RMP and PZA. CONCLUSION: The results indicate that RMP concentrations are below the reference range in most patients, while PZA is within the target range of the standard doses. SN - 1815-7920 UR - https://www.unboundmedicine.com/medline/citation/24200276/Isoniazid_rifampicin_and_pyrazinamide_plasma_concentrations_2_and_6_h_post_dose_in_patients_with_pulmonary_tuberculosis_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1027-3719&volume=17&issue=12&spage=1602&aulast=Fahimi DB - PRIME DP - Unbound Medicine ER -