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The effects of perindopril on cognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress.
Pharmacol Biochem Behav. 2013 Dec; 114-115:31-6.PB

Abstract

Preclinical and clinical studies indicate involvement of renin angiotensin system (RAS) in memory functions. However, exact role of RAS in cognition is still ambiguous. The present study investigated the effects of perindopril on dementia of Alzheimer's type induced by d-galactose (d-gal) and aluminum trichloride (AlCl3). Perindopril, an angiotensin converting enzyme inhibitor, was administered intragastrically (0.5mg/kg/day) for 60days after mice were given d-gal (150mg/kg/day) and AlCl3 (10mg/kg/day) intraperitoneally for 90days. Then, memory function was evaluated by Morris water maze test. The biochemical studies were conducted in cerebral cortex and hippocampus of mouse brain after the behavioral studies. d-Gal and AlCl3 caused significant memory impairment along with significant elevation of acetylcholinesterase (AChE) activity in cerebral cortex and hippocampus. Further, a significant reduction of superoxide dismutases (SOD) and glutathione peroxidase (GSH-Px) activities, and elevation of malondialdehyde (MDA) level in cerebral cortex and hippocampus were observed. Perindopril not only improved cognitive impairment but also restored the elevation of AChE activity induced by d-gal and AlCl3. In addition, perindopril significantly increased SOD and GSH-Px activities, reduced MDA level in cerebral cortex and hippocampus. Taken together, the above findings indicate that perindopril improves learning and memorizing probably by restoring cholinergic function and attenuating oxidative damage.

Authors+Show Affiliations

Department of Human Anatomy, Histology and Embryology, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Xi'an Jiaotong University College of Medicine, 76 Yanta West Road, Xi'an 710061, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24201055

Citation

Yang, Wei-Na, et al. "The Effects of Perindopril On Cognitive Impairment Induced By D-galactose and Aluminum Trichloride Via Inhibition of Acetylcholinesterase Activity and Oxidative Stress." Pharmacology, Biochemistry, and Behavior, vol. 114-115, 2013, pp. 31-6.
Yang WN, Han H, Hu XD, et al. The effects of perindopril on cognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress. Pharmacol Biochem Behav. 2013;114-115:31-6.
Yang, W. N., Han, H., Hu, X. D., Feng, G. F., & Qian, Y. H. (2013). The effects of perindopril on cognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress. Pharmacology, Biochemistry, and Behavior, 114-115, 31-6. https://doi.org/10.1016/j.pbb.2013.10.027
Yang WN, et al. The Effects of Perindopril On Cognitive Impairment Induced By D-galactose and Aluminum Trichloride Via Inhibition of Acetylcholinesterase Activity and Oxidative Stress. Pharmacol Biochem Behav. 2013;114-115:31-6. PubMed PMID: 24201055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of perindopril on cognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress. AU - Yang,Wei-Na, AU - Han,Hua, AU - Hu,Xiao-Dan, AU - Feng,Gai-Feng, AU - Qian,Yi-Hua, Y1 - 2013/11/04/ PY - 2013/04/18/received PY - 2013/10/23/revised PY - 2013/10/26/accepted PY - 2013/11/9/entrez PY - 2013/11/10/pubmed PY - 2014/7/23/medline KW - Acetylcholinesterase KW - Alzheimer's disease KW - Cognitive impairment KW - Oxidative stress KW - Perindopril SP - 31 EP - 6 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 114-115 N2 - Preclinical and clinical studies indicate involvement of renin angiotensin system (RAS) in memory functions. However, exact role of RAS in cognition is still ambiguous. The present study investigated the effects of perindopril on dementia of Alzheimer's type induced by d-galactose (d-gal) and aluminum trichloride (AlCl3). Perindopril, an angiotensin converting enzyme inhibitor, was administered intragastrically (0.5mg/kg/day) for 60days after mice were given d-gal (150mg/kg/day) and AlCl3 (10mg/kg/day) intraperitoneally for 90days. Then, memory function was evaluated by Morris water maze test. The biochemical studies were conducted in cerebral cortex and hippocampus of mouse brain after the behavioral studies. d-Gal and AlCl3 caused significant memory impairment along with significant elevation of acetylcholinesterase (AChE) activity in cerebral cortex and hippocampus. Further, a significant reduction of superoxide dismutases (SOD) and glutathione peroxidase (GSH-Px) activities, and elevation of malondialdehyde (MDA) level in cerebral cortex and hippocampus were observed. Perindopril not only improved cognitive impairment but also restored the elevation of AChE activity induced by d-gal and AlCl3. In addition, perindopril significantly increased SOD and GSH-Px activities, reduced MDA level in cerebral cortex and hippocampus. Taken together, the above findings indicate that perindopril improves learning and memorizing probably by restoring cholinergic function and attenuating oxidative damage. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/24201055/The_effects_of_perindopril_on_cognitive_impairment_induced_by_d_galactose_and_aluminum_trichloride_via_inhibition_of_acetylcholinesterase_activity_and_oxidative_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(13)00273-6 DB - PRIME DP - Unbound Medicine ER -