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AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens.
Clin Exp Immunol. 1986 Jan; 63(1):163-70.CE

Abstract

We have examined the allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR) stimulating activities of T cells precultured in vitro with soluble allogeneic or autologous HLA-DR antigens. These cells (Ts) are known to suppress the human MLR: this suppression is specific in that it occurs only when stimulator cells have the same HLA-DR antigen as that used to induce differentiation of suppressor cells. Ts cells express new membrane specificities; they can be separated by immunoabsorption into two populations: Ts enriched (Tx+; with suppressive activity) and Ts depleted (Ts-; with helper function). In the present study, we have demonstrated that both Ts cell subsets activated by soluble HLA-DR alloantigens are able to stimulate both MLR and AMLR. Ts cells activated by soluble autologous HLA-DR antigens are able to stimulate MLR, but not AMLR.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2420496

Citation

Vanoli, M, et al. "AMLR and MLR Stimulating Activity of Human T Lymphocytes Activated in Vitro By Soluble HLA-DR Antigens." Clinical and Experimental Immunology, vol. 63, no. 1, 1986, pp. 163-70.
Vanoli M, Scorza Smeraldi R, Fabio G, et al. AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens. Clin Exp Immunol. 1986;63(1):163-70.
Vanoli, M., Scorza Smeraldi, R., Fabio, G., Bonara, P., Sabbadini, M. G., & Zanussi, C. (1986). AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens. Clinical and Experimental Immunology, 63(1), 163-70.
Vanoli M, et al. AMLR and MLR Stimulating Activity of Human T Lymphocytes Activated in Vitro By Soluble HLA-DR Antigens. Clin Exp Immunol. 1986;63(1):163-70. PubMed PMID: 2420496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens. AU - Vanoli,M, AU - Scorza Smeraldi,R, AU - Fabio,G, AU - Bonara,P, AU - Sabbadini,M G, AU - Zanussi,C, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 163 EP - 70 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 63 IS - 1 N2 - We have examined the allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR) stimulating activities of T cells precultured in vitro with soluble allogeneic or autologous HLA-DR antigens. These cells (Ts) are known to suppress the human MLR: this suppression is specific in that it occurs only when stimulator cells have the same HLA-DR antigen as that used to induce differentiation of suppressor cells. Ts cells express new membrane specificities; they can be separated by immunoabsorption into two populations: Ts enriched (Tx+; with suppressive activity) and Ts depleted (Ts-; with helper function). In the present study, we have demonstrated that both Ts cell subsets activated by soluble HLA-DR alloantigens are able to stimulate both MLR and AMLR. Ts cells activated by soluble autologous HLA-DR antigens are able to stimulate MLR, but not AMLR. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/2420496/AMLR_and_MLR_stimulating_activity_of_human_T_lymphocytes_activated_in_vitro_by_soluble_HLA_DR_antigens_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/2420496/ DB - PRIME DP - Unbound Medicine ER -