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[The worldwide standardization of hemoglobin A1c measurement: the current statement from the Japan Diabetes Society and the issues to be solved].
Rinsho Byori. 2013 Jul; 61(7):594-601.RB

Abstract

The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) have recently decided to use both units in the hemoglobin A1c (HbA1c) measurement based on the NGSP (previously called the National Glycohemoglobin Standardization Program) and the IFCC (International Federation of Clinical Chemistry) in articles and scientific meetings, whereas each country or region may use either NGSP units (conventional %) or IFCC units (SI; mmol/mol) in common practice. This is expressed as "a new twist on the path to harmony" in the measurement of HbA1c. Accordingly, the Japan Diabetes Society has used only NGSP units as of April 1, 2013, whereas the previous JDS units will be used for the high reproducibility of the JDS Standardization System but not in the clinical setting. JDS units are converted to NGSP units using JDS lots in Japan. Unfortunately however, there are significant differences between NGSP values obtained by the previously reported IFCC-JDS equations and those currently available in Japan. Therefore, this paper argues that IFCC units as the only valid anchor for scientific standardization should seek robust master equations for NGSP and JDS units. Furthermore, the biological variability of HbAlc, such as the Hemoglobin Glycation Index and the Glycation Gap, may be accurately evaluated by IFCC units because the values do not include additional factors such as non-glycated Hb in JDS and NGSP units.

Authors+Show Affiliations

Department of Pediatrics, Saitama Medical School, Iruma-gun, Saitama-pref. 350-0495, Japan. shin_a@saitama-med.ac.jpNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

jpn

PubMed ID

24205700

Citation

Amemiya, Shin, and Tadao Hoshino. "[The Worldwide Standardization of Hemoglobin A1c Measurement: the Current Statement From the Japan Diabetes Society and the Issues to Be Solved]." Rinsho Byori. the Japanese Journal of Clinical Pathology, vol. 61, no. 7, 2013, pp. 594-601.
Amemiya S, Hoshino T. [The worldwide standardization of hemoglobin A1c measurement: the current statement from the Japan Diabetes Society and the issues to be solved]. Rinsho Byori. 2013;61(7):594-601.
Amemiya, S., & Hoshino, T. (2013). [The worldwide standardization of hemoglobin A1c measurement: the current statement from the Japan Diabetes Society and the issues to be solved]. Rinsho Byori. the Japanese Journal of Clinical Pathology, 61(7), 594-601.
Amemiya S, Hoshino T. [The Worldwide Standardization of Hemoglobin A1c Measurement: the Current Statement From the Japan Diabetes Society and the Issues to Be Solved]. Rinsho Byori. 2013;61(7):594-601. PubMed PMID: 24205700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The worldwide standardization of hemoglobin A1c measurement: the current statement from the Japan Diabetes Society and the issues to be solved]. AU - Amemiya,Shin, AU - Hoshino,Tadao, PY - 2013/11/12/entrez PY - 2013/11/12/pubmed PY - 2013/12/25/medline SP - 594 EP - 601 JF - Rinsho byori. The Japanese journal of clinical pathology JO - Rinsho Byori VL - 61 IS - 7 N2 - The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) have recently decided to use both units in the hemoglobin A1c (HbA1c) measurement based on the NGSP (previously called the National Glycohemoglobin Standardization Program) and the IFCC (International Federation of Clinical Chemistry) in articles and scientific meetings, whereas each country or region may use either NGSP units (conventional %) or IFCC units (SI; mmol/mol) in common practice. This is expressed as "a new twist on the path to harmony" in the measurement of HbA1c. Accordingly, the Japan Diabetes Society has used only NGSP units as of April 1, 2013, whereas the previous JDS units will be used for the high reproducibility of the JDS Standardization System but not in the clinical setting. JDS units are converted to NGSP units using JDS lots in Japan. Unfortunately however, there are significant differences between NGSP values obtained by the previously reported IFCC-JDS equations and those currently available in Japan. Therefore, this paper argues that IFCC units as the only valid anchor for scientific standardization should seek robust master equations for NGSP and JDS units. Furthermore, the biological variability of HbAlc, such as the Hemoglobin Glycation Index and the Glycation Gap, may be accurately evaluated by IFCC units because the values do not include additional factors such as non-glycated Hb in JDS and NGSP units. SN - 0047-1860 UR - https://www.unboundmedicine.com/medline/citation/24205700/[The_worldwide_standardization_of_hemoglobin_A1c_measurement:_the_current_statement_from_the_Japan_Diabetes_Society_and_the_issues_to_be_solved]_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0047-1860&volume=61&issue=7&spage=594 DB - PRIME DP - Unbound Medicine ER -
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