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Salivary biomarkers of oxidative stress and quality of life in patients with oral lichen planus.
Geriatr Gerontol Int. 2014 Jul; 14(3):654-9.GG

Abstract

AIM

Lichen planus is a T cell-mediated chronic inflammatory disease of unknown etiology. The objective of the present study was to evaluate the status of oxidative stress in saliva and the anti-oxidant defense system in relation to quality of life parameters in patients with oral lichen planus (OLP).

METHODS

The sample consisted of 70 patients (40 with OLP and 30 control patients). The average age of OLP patients was 60 years (9 males and 31 females), and of the control group 57 years (6 males and 24 females). All participants completed the Oral Health Impact Profile-49 quality of life questionnaire. Total anti-oxidant activity and lipid peroxidation products in saliva were evaluated, using ferric reducing anti-oxidant power and thiobarbituric acid reactive substance.

RESULTS

Mean levels of salivary malondialdehyde were higher in the OLP group than the control group (P = 0.001), and total anti-oxidant capacity was lower among OLP patients than control patients (P = 0.02). There was no correlation between Oral Health Impact Profile-49 findings and the oxidative stress parameters studied.

CONCLUSIONS

The results of the present study point to the possible function of oxidative stress in the etiopathogenesis of OLP.

Authors+Show Affiliations

Oral Medicine, Ageing Research Institute, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24205825

Citation

Lopez-Jornet, Pia, et al. "Salivary Biomarkers of Oxidative Stress and Quality of Life in Patients With Oral Lichen Planus." Geriatrics & Gerontology International, vol. 14, no. 3, 2014, pp. 654-9.
Lopez-Jornet P, Martinez-Canovas A, Pons-Fuster A. Salivary biomarkers of oxidative stress and quality of life in patients with oral lichen planus. Geriatr Gerontol Int. 2014;14(3):654-9.
Lopez-Jornet, P., Martinez-Canovas, A., & Pons-Fuster, A. (2014). Salivary biomarkers of oxidative stress and quality of life in patients with oral lichen planus. Geriatrics & Gerontology International, 14(3), 654-9. https://doi.org/10.1111/ggi.12153
Lopez-Jornet P, Martinez-Canovas A, Pons-Fuster A. Salivary Biomarkers of Oxidative Stress and Quality of Life in Patients With Oral Lichen Planus. Geriatr Gerontol Int. 2014;14(3):654-9. PubMed PMID: 24205825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary biomarkers of oxidative stress and quality of life in patients with oral lichen planus. AU - Lopez-Jornet,Pia, AU - Martinez-Canovas,Ascension, AU - Pons-Fuster,Alvaro, Y1 - 2013/11/11/ PY - 2013/08/04/accepted PY - 2013/11/12/entrez PY - 2013/11/12/pubmed PY - 2015/5/12/medline KW - malondialdehyde KW - oxidative stress KW - quality of life KW - saliva SP - 654 EP - 9 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 14 IS - 3 N2 - AIM: Lichen planus is a T cell-mediated chronic inflammatory disease of unknown etiology. The objective of the present study was to evaluate the status of oxidative stress in saliva and the anti-oxidant defense system in relation to quality of life parameters in patients with oral lichen planus (OLP). METHODS: The sample consisted of 70 patients (40 with OLP and 30 control patients). The average age of OLP patients was 60 years (9 males and 31 females), and of the control group 57 years (6 males and 24 females). All participants completed the Oral Health Impact Profile-49 quality of life questionnaire. Total anti-oxidant activity and lipid peroxidation products in saliva were evaluated, using ferric reducing anti-oxidant power and thiobarbituric acid reactive substance. RESULTS: Mean levels of salivary malondialdehyde were higher in the OLP group than the control group (P = 0.001), and total anti-oxidant capacity was lower among OLP patients than control patients (P = 0.02). There was no correlation between Oral Health Impact Profile-49 findings and the oxidative stress parameters studied. CONCLUSIONS: The results of the present study point to the possible function of oxidative stress in the etiopathogenesis of OLP. SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/24205825/Salivary_biomarkers_of_oxidative_stress_and_quality_of_life_in_patients_with_oral_lichen_planus_ L2 - https://doi.org/10.1111/ggi.12153 DB - PRIME DP - Unbound Medicine ER -