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Enantioselective synthesis of 2,3-disubstituted indanones via Pd-catalyzed intramolecular asymmetric allylic alkylation of ketones.
Org Lett. 2013 Dec 06; 15(23):6086-9.OL

Abstract

A Pd-catalyzed intramolecular asymmetric allylic alkylation (AAA) reaction with "hard" carbanions has been developed for the first time, affording 2,3-disubstituted indanones with high diastereo- and enantioselectivities. The transformation of these products into other core structures of natural products has been demonstrated.

Authors+Show Affiliations

State Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24206052

Citation

Li, Xiao-Hui, et al. "Enantioselective Synthesis of 2,3-disubstituted Indanones Via Pd-catalyzed Intramolecular Asymmetric Allylic Alkylation of Ketones." Organic Letters, vol. 15, no. 23, 2013, pp. 6086-9.
Li XH, Zheng BH, Ding CH, et al. Enantioselective synthesis of 2,3-disubstituted indanones via Pd-catalyzed intramolecular asymmetric allylic alkylation of ketones. Org Lett. 2013;15(23):6086-9.
Li, X. H., Zheng, B. H., Ding, C. H., & Hou, X. L. (2013). Enantioselective synthesis of 2,3-disubstituted indanones via Pd-catalyzed intramolecular asymmetric allylic alkylation of ketones. Organic Letters, 15(23), 6086-9. https://doi.org/10.1021/ol402980v
Li XH, et al. Enantioselective Synthesis of 2,3-disubstituted Indanones Via Pd-catalyzed Intramolecular Asymmetric Allylic Alkylation of Ketones. Org Lett. 2013 Dec 6;15(23):6086-9. PubMed PMID: 24206052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioselective synthesis of 2,3-disubstituted indanones via Pd-catalyzed intramolecular asymmetric allylic alkylation of ketones. AU - Li,Xiao-Hui, AU - Zheng,Bao-Hui, AU - Ding,Chang-Hua, AU - Hou,Xue-Long, Y1 - 2013/11/08/ PY - 2013/11/12/entrez PY - 2013/11/12/pubmed PY - 2014/5/3/medline SP - 6086 EP - 9 JF - Organic letters JO - Org Lett VL - 15 IS - 23 N2 - A Pd-catalyzed intramolecular asymmetric allylic alkylation (AAA) reaction with "hard" carbanions has been developed for the first time, affording 2,3-disubstituted indanones with high diastereo- and enantioselectivities. The transformation of these products into other core structures of natural products has been demonstrated. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/24206052/Enantioselective_synthesis_of_23_disubstituted_indanones_via_Pd_catalyzed_intramolecular_asymmetric_allylic_alkylation_of_ketones_ DB - PRIME DP - Unbound Medicine ER -