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Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease.
BMC Gastroenterol 2013; 13:157BG

Abstract

BACKGROUND

Celiac disease (CD) is an autoimmune disorder, characterized by the presence of gastrointestinal and multisystem symptoms, which occasionally mimic those of Irritable Bowel Syndrome (IBS) and Fibromyalgia Syndrome (FMS). To assess the effectiveness of a Gluten-Free Diet (GFD) in seven adult female screening-detected CD subjects, categorized as severe IBS and FMS patients.

METHODS

All subjects showed villous atrophy in duodenal biopsies, were HLA-DQ2/DQ8-positive, and fulfilled the Rome III and ACR 1990 criteria respectively for IBS and FMS classification. GFD effectiveness was assessed at baseline and after 1 year, examining the score changes in the Tender Points (TPs) test, Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire (HAQ), Short Form Health Survey (SF-36), Visual Analogue Scales (VAS) for gastrointestinal complaints, pain and tiredness, drug prescriptions and tissue-Trans-Glutaminase (tTG) serum levels.

RESULTS

At baseline, all patients had poor Quality of Life and VAS scores, a high number of TPs and drug prescriptions, and increased tTG levels. After 1 year of GFD, all outcome measures significantly improved, with a decrease of 51-60% in TPs, FIQ, HAQ, and VAS scales, and in the number of prescribed drugs, accompanied by an increase of 48-60% in SF-36 Physical and Mental Component Summary scores, and a decrease of tTG to normal values.

CONCLUSION

Results of this pilot study show that the adherence to a GFD by CD-related IBS/FMS patients can simultaneously improve CD and IBS/FMS symptoms, and indicate the merit of further research on a larger cohort.

Authors+Show Affiliations

Gastroenterology, Central University Hospital of Asturias (HUCA), Celestino Villamil, s/n, 33006, Oviedo, Principality of Asturias, Spain. lrodrigosaez@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24209578

Citation

Rodrigo, Luis, et al. "Clinical Impact of a Gluten-free Diet On Health-related Quality of Life in Seven Fibromyalgia Syndrome Patients With Associated Celiac Disease." BMC Gastroenterology, vol. 13, 2013, p. 157.
Rodrigo L, Blanco I, Bobes J, et al. Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease. BMC Gastroenterol. 2013;13:157.
Rodrigo, L., Blanco, I., Bobes, J., & de Serres, F. J. (2013). Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease. BMC Gastroenterology, 13, p. 157. doi:10.1186/1471-230X-13-157.
Rodrigo L, et al. Clinical Impact of a Gluten-free Diet On Health-related Quality of Life in Seven Fibromyalgia Syndrome Patients With Associated Celiac Disease. BMC Gastroenterol. 2013 Nov 9;13:157. PubMed PMID: 24209578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease. AU - Rodrigo,Luis, AU - Blanco,Ignacio, AU - Bobes,Julio, AU - de Serres,Frederick J, Y1 - 2013/11/09/ PY - 2013/05/12/received PY - 2013/11/04/accepted PY - 2013/11/12/entrez PY - 2013/11/12/pubmed PY - 2014/9/1/medline SP - 157 EP - 157 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 13 N2 - BACKGROUND: Celiac disease (CD) is an autoimmune disorder, characterized by the presence of gastrointestinal and multisystem symptoms, which occasionally mimic those of Irritable Bowel Syndrome (IBS) and Fibromyalgia Syndrome (FMS). To assess the effectiveness of a Gluten-Free Diet (GFD) in seven adult female screening-detected CD subjects, categorized as severe IBS and FMS patients. METHODS: All subjects showed villous atrophy in duodenal biopsies, were HLA-DQ2/DQ8-positive, and fulfilled the Rome III and ACR 1990 criteria respectively for IBS and FMS classification. GFD effectiveness was assessed at baseline and after 1 year, examining the score changes in the Tender Points (TPs) test, Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire (HAQ), Short Form Health Survey (SF-36), Visual Analogue Scales (VAS) for gastrointestinal complaints, pain and tiredness, drug prescriptions and tissue-Trans-Glutaminase (tTG) serum levels. RESULTS: At baseline, all patients had poor Quality of Life and VAS scores, a high number of TPs and drug prescriptions, and increased tTG levels. After 1 year of GFD, all outcome measures significantly improved, with a decrease of 51-60% in TPs, FIQ, HAQ, and VAS scales, and in the number of prescribed drugs, accompanied by an increase of 48-60% in SF-36 Physical and Mental Component Summary scores, and a decrease of tTG to normal values. CONCLUSION: Results of this pilot study show that the adherence to a GFD by CD-related IBS/FMS patients can simultaneously improve CD and IBS/FMS symptoms, and indicate the merit of further research on a larger cohort. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/24209578/Clinical_impact_of_a_gluten_free_diet_on_health_related_quality_of_life_in_seven_fibromyalgia_syndrome_patients_with_associated_celiac_disease_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-157 DB - PRIME DP - Unbound Medicine ER -