Tags

Type your tag names separated by a space and hit enter

IB-LBM simulation on blood cell sorting with a micro-fence structure.
Biomed Mater Eng 2014; 24(1):475-81BM

Abstract

A size-based blood cell sorting model with a micro-fence structure is proposed in the frame of immersed boundary and lattice Boltzmann method (IB-LBM). The fluid dynamics is obtained by solving the discrete lattice Boltzmann equation, and the cells motion and deformation are handled by the immersed boundary method. A micro-fence consists of two parallel slope post rows which are adopted to separate red blood cells (RBCs) from white blood cells (WBCs), in which the cells to be separated are transported one after another by the flow into the passageway between the two post rows. Effected by the cross flow, RBCs are schemed to get through the pores of the nether post row since they are smaller and more deformable compared with WBCs. WBCs are required to move along the nether post row till they get out the micro-fence. Simulation results indicate that for a fix width of pores, the slope angle of the post row plays an important role in cell sorting. The cells mixture can not be separated properly in a small slope angle, while obvious blockages by WBCs will take place to disturb the continuous cell sorting in a big slope angle. As an optimal result, an adaptive slope angle is found to sort RBCs form WBCs correctly and continuously.

Authors+Show Affiliations

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24211930

Citation

Wei, Qiang, et al. "IB-LBM Simulation On Blood Cell Sorting With a Micro-fence Structure." Bio-medical Materials and Engineering, vol. 24, no. 1, 2014, pp. 475-81.
Wei Q, Xu YQ, Tian FB, et al. IB-LBM simulation on blood cell sorting with a micro-fence structure. Biomed Mater Eng. 2014;24(1):475-81.
Wei, Q., Xu, Y. Q., Tian, F. B., Gao, T. X., Tang, X. Y., & Zu, W. H. (2014). IB-LBM simulation on blood cell sorting with a micro-fence structure. Bio-medical Materials and Engineering, 24(1), pp. 475-81. doi:10.3233/BME-130833.
Wei Q, et al. IB-LBM Simulation On Blood Cell Sorting With a Micro-fence Structure. Biomed Mater Eng. 2014;24(1):475-81. PubMed PMID: 24211930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IB-LBM simulation on blood cell sorting with a micro-fence structure. AU - Wei,Qiang, AU - Xu,Yuan-Qing, AU - Tian,Fang-bao, AU - Gao,Tian-xin, AU - Tang,Xiao-ying, AU - Zu,Wen-Hong, PY - 2013/11/12/entrez PY - 2013/11/12/pubmed PY - 2014/6/24/medline KW - Blood cell separation KW - Cross flow KW - Lattice Boltzmann method KW - Microfludics KW - immersed Boundary SP - 475 EP - 81 JF - Bio-medical materials and engineering JO - Biomed Mater Eng VL - 24 IS - 1 N2 - A size-based blood cell sorting model with a micro-fence structure is proposed in the frame of immersed boundary and lattice Boltzmann method (IB-LBM). The fluid dynamics is obtained by solving the discrete lattice Boltzmann equation, and the cells motion and deformation are handled by the immersed boundary method. A micro-fence consists of two parallel slope post rows which are adopted to separate red blood cells (RBCs) from white blood cells (WBCs), in which the cells to be separated are transported one after another by the flow into the passageway between the two post rows. Effected by the cross flow, RBCs are schemed to get through the pores of the nether post row since they are smaller and more deformable compared with WBCs. WBCs are required to move along the nether post row till they get out the micro-fence. Simulation results indicate that for a fix width of pores, the slope angle of the post row plays an important role in cell sorting. The cells mixture can not be separated properly in a small slope angle, while obvious blockages by WBCs will take place to disturb the continuous cell sorting in a big slope angle. As an optimal result, an adaptive slope angle is found to sort RBCs form WBCs correctly and continuously. SN - 1878-3619 UR - https://www.unboundmedicine.com/medline/citation/24211930/IB_LBM_simulation_on_blood_cell_sorting_with_a_micro_fence_structure_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/BME-130833 DB - PRIME DP - Unbound Medicine ER -