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Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial.
J Atten Disord. 2015 Nov; 19(11):954-64.JA

Abstract

OBJECTIVE

To investigate effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on attention, literacy, and behavior in children with ADHD.

METHOD

Ninety children were randomized to consume supplements high in EPA, DHA, or linoleic acid (control) for 4 months each in a crossover design. Erythrocyte fatty acids, attention, cognition, literacy, and Conners' Parent Rating Scales (CPRS) were measured at 0, 4, 8, 12 months.

RESULTS

Fifty-three children completed the treatment. Outcome measures showed no significant differences between the three treatments. However, in children with blood samples (n = 76-46), increased erythrocyte EPA + DHA was associated with improved spelling (r = .365, p < .001) and attention (r = -.540, p < .001) and reduced oppositional behavior (r = -.301, p < .003), hyperactivity (r = -.310, p < .001), cognitive problems (r = -.326, p < .001), Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) hyperactivity (r = -.270, p = .002) and DSM-IV inattention (r = -.343, p < .001).

CONCLUSION

Increasing erythrocyte DHA and EPA via dietary supplementation may improve behavior, attention, and literacy in children with ADHD.

Authors+Show Affiliations

Deakin University, Melbourne, Victoria, Australia.University of South Australia, Adelaide, Australia natalie.parletta@unisa.edu.au.University of South Australia, Adelaide, Australia.University of South Australia, Adelaide, Australia.Queensland University of Technology, Brisbane, Australia.University of Newcastle, Callaghan, New South Wales, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24214970

Citation

Milte, Catherine M., et al. "Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial." Journal of Attention Disorders, vol. 19, no. 11, 2015, pp. 954-64.
Milte CM, Parletta N, Buckley JD, et al. Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial. J Atten Disord. 2015;19(11):954-64.
Milte, C. M., Parletta, N., Buckley, J. D., Coates, A. M., Young, R. M., & Howe, P. R. (2015). Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial. Journal of Attention Disorders, 19(11), 954-64. https://doi.org/10.1177/1087054713510562
Milte CM, et al. Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial. J Atten Disord. 2015;19(11):954-64. PubMed PMID: 24214970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial. AU - Milte,Catherine M, AU - Parletta,Natalie, AU - Buckley,Jonathan D, AU - Coates,Alison M, AU - Young,Ross M, AU - Howe,Peter R C, Y1 - 2013/11/08/ PY - 2013/11/12/entrez PY - 2013/11/12/pubmed PY - 2016/4/19/medline KW - ADD/ADHD KW - behavior KW - cognition KW - fatty acid KW - nutrition SP - 954 EP - 64 JF - Journal of attention disorders JO - J Atten Disord VL - 19 IS - 11 N2 - OBJECTIVE: To investigate effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on attention, literacy, and behavior in children with ADHD. METHOD: Ninety children were randomized to consume supplements high in EPA, DHA, or linoleic acid (control) for 4 months each in a crossover design. Erythrocyte fatty acids, attention, cognition, literacy, and Conners' Parent Rating Scales (CPRS) were measured at 0, 4, 8, 12 months. RESULTS: Fifty-three children completed the treatment. Outcome measures showed no significant differences between the three treatments. However, in children with blood samples (n = 76-46), increased erythrocyte EPA + DHA was associated with improved spelling (r = .365, p < .001) and attention (r = -.540, p < .001) and reduced oppositional behavior (r = -.301, p < .003), hyperactivity (r = -.310, p < .001), cognitive problems (r = -.326, p < .001), Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) hyperactivity (r = -.270, p = .002) and DSM-IV inattention (r = -.343, p < .001). CONCLUSION: Increasing erythrocyte DHA and EPA via dietary supplementation may improve behavior, attention, and literacy in children with ADHD. SN - 1557-1246 UR - https://www.unboundmedicine.com/medline/citation/24214970/Increased_Erythrocyte_Eicosapentaenoic_Acid_and_Docosahexaenoic_Acid_Are_Associated_With_Improved_Attention_and_Behavior_in_Children_With_ADHD_in_a_Randomized_Controlled_Three_Way_Crossover_Trial_ L2 - https://journals.sagepub.com/doi/10.1177/1087054713510562?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -