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Ratio of "A-type" to "B-type" proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells.
J Agric Food Chem 2014; 62(18):3919-25JA

Abstract

Gut colonization by extra-intestinal pathogenic Escherichia coli (ExPEC) increases the risk of subsequent infections, including urinary tract infection and septicemia. Previous work suggests that cranberry proanthocyanidins (PAC) interact with bacterial surface factors, altering bacterial interaction with host cells. Methods were developed to determine if ratios of "A-type" to "B-type" interflavan bonds in PAC affect ExPEC agglutination and invasion of enterocytes. In cranberries, 94.5% of PAC contain one or more "A-type" bonds, whereas in apples, 88.3% of PAC contain exclusively "B-type" bonds. Results show that cranberry "A-type" PAC have greater bioactivity than apple "B-type" PAC for increasing ExPEC agglutination and decreasing ExPEC epithelial cell invasion.

Authors+Show Affiliations

Department of Food Science, University of Wisconsin-Madison , 1605 Linden Drive, Madison, Wisconsin 53706, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24215458

Citation

Feliciano, Rodrigo P., et al. "Ratio of "A-type" to "B-type" Proanthocyanidin Interflavan Bonds Affects Extra-intestinal Pathogenic Escherichia Coli Invasion of Gut Epithelial Cells." Journal of Agricultural and Food Chemistry, vol. 62, no. 18, 2014, pp. 3919-25.
Feliciano RP, Meudt JJ, Shanmuganayagam D, et al. Ratio of "A-type" to "B-type" proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells. J Agric Food Chem. 2014;62(18):3919-25.
Feliciano, R. P., Meudt, J. J., Shanmuganayagam, D., Krueger, C. G., & Reed, J. D. (2014). Ratio of "A-type" to "B-type" proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells. Journal of Agricultural and Food Chemistry, 62(18), pp. 3919-25. doi:10.1021/jf403839a.
Feliciano RP, et al. Ratio of "A-type" to "B-type" Proanthocyanidin Interflavan Bonds Affects Extra-intestinal Pathogenic Escherichia Coli Invasion of Gut Epithelial Cells. J Agric Food Chem. 2014 May 7;62(18):3919-25. PubMed PMID: 24215458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ratio of "A-type" to "B-type" proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells. AU - Feliciano,Rodrigo P, AU - Meudt,Jennifer J, AU - Shanmuganayagam,Dhanansayan, AU - Krueger,Christian G, AU - Reed,Jess D, Y1 - 2013/11/18/ PY - 2013/11/13/entrez PY - 2013/11/13/pubmed PY - 2015/11/13/medline KW - Caco-2 KW - ExPEC KW - agglutination KW - apple KW - cranberry KW - invasion KW - proanthocyanidins KW - “A-type” bonds KW - “B-type” bonds SP - 3919 EP - 25 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 62 IS - 18 N2 - Gut colonization by extra-intestinal pathogenic Escherichia coli (ExPEC) increases the risk of subsequent infections, including urinary tract infection and septicemia. Previous work suggests that cranberry proanthocyanidins (PAC) interact with bacterial surface factors, altering bacterial interaction with host cells. Methods were developed to determine if ratios of "A-type" to "B-type" interflavan bonds in PAC affect ExPEC agglutination and invasion of enterocytes. In cranberries, 94.5% of PAC contain one or more "A-type" bonds, whereas in apples, 88.3% of PAC contain exclusively "B-type" bonds. Results show that cranberry "A-type" PAC have greater bioactivity than apple "B-type" PAC for increasing ExPEC agglutination and decreasing ExPEC epithelial cell invasion. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/24215458/Ratio_of_"A_type"_to_"B_type"_proanthocyanidin_interflavan_bonds_affects_extra_intestinal_pathogenic_Escherichia_coli_invasion_of_gut_epithelial_cells_ L2 - https://dx.doi.org/10.1021/jf403839a DB - PRIME DP - Unbound Medicine ER -