Tags

Type your tag names separated by a space and hit enter

Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors.
J Asian Nat Prod Res. 2013 Nov; 15(11):1179-88.JA

Abstract

In an attempt to improve the antitumor activity of homocamptothecins (hCPTs), a series of novel 20-O-linked hCPT ester derivatives were first designed and synthesized based on a synthetic route, by which hCPTs are acylated with different substituted phenoxyacetic acid ester derivatives. Most of the derivatives were assayed for in vitro cytotoxicity against six human cancer cell lines KB, KB/VCR, A549, HCT-8, Bel7402, and A2780, and most of the assayed compounds exhibited good antiproliferative activity on these tumor cell lines especially on KB.

Links

Publisher Full Text

Authors+Show Affiliations

Li DZ
a College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin , 300071 , China.
Wang CY
No affiliation info available
Liu RH
No affiliation info available
Wang YM
No affiliation info available
Ji TF
No affiliation info available
Li YR
No affiliation info available
Pan XD
No affiliation info available

MeSH

Antineoplastic AgentsCamptothecinDrug Screening Assays, AntitumorEstersHumansInhibitory Concentration 50KB CellsMolecular StructureStructure-Activity RelationshipTopoisomerase I Inhibitors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24215541

Citation

Li, Di-Zao, et al. "Synthesis and Cytotoxicity of Novel 20-O-linked Homocamptothecin Ester Derivatives as Potent Topoisomerase I Inhibitors." Journal of Asian Natural Products Research, vol. 15, no. 11, 2013, pp. 1179-88.
Li DZ, Wang CY, Liu RH, et al. Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors. J Asian Nat Prod Res. 2013;15(11):1179-88.
Li, D. Z., Wang, C. Y., Liu, R. H., Wang, Y. M., Ji, T. F., Li, Y. R., & Pan, X. D. (2013). Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors. Journal of Asian Natural Products Research, 15(11), 1179-88. https://doi.org/10.1080/10286020.2013.855203
Li DZ, et al. Synthesis and Cytotoxicity of Novel 20-O-linked Homocamptothecin Ester Derivatives as Potent Topoisomerase I Inhibitors. J Asian Nat Prod Res. 2013;15(11):1179-88. PubMed PMID: 24215541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors. AU - Li,Di-Zao, AU - Wang,Cun-Ying, AU - Liu,Rui-Hua, AU - Wang,Yan-Ming, AU - Ji,Teng-Fei, AU - Li,Yu-Rong, AU - Pan,Xian-Dao, Y1 - 2013/11/11/ PY - 2013/11/13/entrez PY - 2013/11/13/pubmed PY - 2014/3/13/medline SP - 1179 EP - 88 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 15 IS - 11 N2 - In an attempt to improve the antitumor activity of homocamptothecins (hCPTs), a series of novel 20-O-linked hCPT ester derivatives were first designed and synthesized based on a synthetic route, by which hCPTs are acylated with different substituted phenoxyacetic acid ester derivatives. Most of the derivatives were assayed for in vitro cytotoxicity against six human cancer cell lines KB, KB/VCR, A549, HCT-8, Bel7402, and A2780, and most of the assayed compounds exhibited good antiproliferative activity on these tumor cell lines especially on KB. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/24215541/Synthesis_and_cytotoxicity_of_novel_20_O_linked_homocamptothecin_ester_derivatives_as_potent_topoisomerase_I_inhibitors_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020.2013.855203 DB - PRIME DP - Unbound Medicine ER -