Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors.J Asian Nat Prod Res. 2013 Nov; 15(11):1179-88.JA
Abstract
In an attempt to improve the antitumor activity of homocamptothecins (hCPTs), a series of novel 20-O-linked hCPT ester derivatives were first designed and synthesized based on a synthetic route, by which hCPTs are acylated with different substituted phenoxyacetic acid ester derivatives. Most of the derivatives were assayed for in vitro cytotoxicity against six human cancer cell lines KB, KB/VCR, A549, HCT-8, Bel7402, and A2780, and most of the assayed compounds exhibited good antiproliferative activity on these tumor cell lines especially on KB.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
24215541
Citation
Li, Di-Zao, et al. "Synthesis and Cytotoxicity of Novel 20-O-linked Homocamptothecin Ester Derivatives as Potent Topoisomerase I Inhibitors." Journal of Asian Natural Products Research, vol. 15, no. 11, 2013, pp. 1179-88.
Li DZ, Wang CY, Liu RH, et al. Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors. J Asian Nat Prod Res. 2013;15(11):1179-88.
Li, D. Z., Wang, C. Y., Liu, R. H., Wang, Y. M., Ji, T. F., Li, Y. R., & Pan, X. D. (2013). Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors. Journal of Asian Natural Products Research, 15(11), 1179-88. https://doi.org/10.1080/10286020.2013.855203
Li DZ, et al. Synthesis and Cytotoxicity of Novel 20-O-linked Homocamptothecin Ester Derivatives as Potent Topoisomerase I Inhibitors. J Asian Nat Prod Res. 2013;15(11):1179-88. PubMed PMID: 24215541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Synthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors.
AU - Li,Di-Zao,
AU - Wang,Cun-Ying,
AU - Liu,Rui-Hua,
AU - Wang,Yan-Ming,
AU - Ji,Teng-Fei,
AU - Li,Yu-Rong,
AU - Pan,Xian-Dao,
Y1 - 2013/11/11/
PY - 2013/11/13/entrez
PY - 2013/11/13/pubmed
PY - 2014/3/13/medline
SP - 1179
EP - 88
JF - Journal of Asian natural products research
JO - J Asian Nat Prod Res
VL - 15
IS - 11
N2 - In an attempt to improve the antitumor activity of homocamptothecins (hCPTs), a series of novel 20-O-linked hCPT ester derivatives were first designed and synthesized based on a synthetic route, by which hCPTs are acylated with different substituted phenoxyacetic acid ester derivatives. Most of the derivatives were assayed for in vitro cytotoxicity against six human cancer cell lines KB, KB/VCR, A549, HCT-8, Bel7402, and A2780, and most of the assayed compounds exhibited good antiproliferative activity on these tumor cell lines especially on KB.
SN - 1477-2213
UR - https://www.unboundmedicine.com/medline/citation/24215541/Synthesis_and_cytotoxicity_of_novel_20_O_linked_homocamptothecin_ester_derivatives_as_potent_topoisomerase_I_inhibitors_
L2 - https://www.tandfonline.com/doi/full/10.1080/10286020.2013.855203
DB - PRIME
DP - Unbound Medicine
ER -