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Dietary fiber intake reduces risk for colorectal adenoma: a meta-analysis.
Gastroenterology 2014; 146(3):689-699.e6G

Abstract

BACKGROUND & AIMS

Reports on the association between dietary fiber intake and risk of colorectal adenoma (CRA), the precursor of colorectal cancer, have been inconsistent. We conducted a meta-analysis of case-control and cohort studies to analyze this association.

METHODS

We searched the MEDLINE and EMBASE databases to identify relevant studies published through July 2013. A random-effects model was used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs) for associations between fiber intake and CRA risk. Heterogeneity among studies was assessed using the Cochran Q and I(2) statistics.

RESULTS

Our meta-analysis included 20 studies involving 10,948 subjects with CRA. The SRRs of CRA for total dietary fiber were 0.72 (95% CI, 0.63-0.83) in a high- vs low-intake analysis and 0.91 (95% CI, 0.87-0.95) per 10-g/day increase in fiber intake in a dose-response model. Subgroup analyses indicated a significant inverse association between total fiber intake and CRA risk in case-control studies (SRR, 0.66; 95% CI, 0.56-0.77), but not in cohort studies (SRR, 0.92; 95% CI, 0.76-1.10). The SRRs of CRA were 0.84 for fruit fiber (95% CI, 0.76-0.94; n = 6 studies), 0.93 for vegetable fiber (95% CI, 0.84-1.04; n = 6 studies), and 0.76 for cereal fiber (95% CI, 0.62-0.92; n = 9 studies) in high- vs low-intake analyses.

CONCLUSIONS

Our findings support the hypothesis that high dietary fiber intake is associated inversely with CRA risk. Further studies with prospective designs that use validated questionnaires and control for important confounders are warranted.

Authors+Show Affiliations

Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, PR China.Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, PR China.Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, PR China.Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, PR China.Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, PR China.Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, PR China. Electronic address: yaozongyuan28@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24216326

Citation

Ben, Qiwen, et al. "Dietary Fiber Intake Reduces Risk for Colorectal Adenoma: a Meta-analysis." Gastroenterology, vol. 146, no. 3, 2014, pp. 689-699.e6.
Ben Q, Sun Y, Chai R, et al. Dietary fiber intake reduces risk for colorectal adenoma: a meta-analysis. Gastroenterology. 2014;146(3):689-699.e6.
Ben, Q., Sun, Y., Chai, R., Qian, A., Xu, B., & Yuan, Y. (2014). Dietary fiber intake reduces risk for colorectal adenoma: a meta-analysis. Gastroenterology, 146(3), pp. 689-699.e6. doi:10.1053/j.gastro.2013.11.003.
Ben Q, et al. Dietary Fiber Intake Reduces Risk for Colorectal Adenoma: a Meta-analysis. Gastroenterology. 2014;146(3):689-699.e6. PubMed PMID: 24216326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber intake reduces risk for colorectal adenoma: a meta-analysis. AU - Ben,Qiwen, AU - Sun,Yunwei, AU - Chai,Rui, AU - Qian,Aihua, AU - Xu,Bin, AU - Yuan,Yaozong, Y1 - 2013/11/08/ PY - 2013/08/12/received PY - 2013/10/31/revised PY - 2013/11/03/accepted PY - 2013/11/13/entrez PY - 2013/11/13/pubmed PY - 2014/5/28/medline KW - Colon Cancer KW - Food KW - Reduction KW - Risk Factor SP - 689 EP - 699.e6 JF - Gastroenterology JO - Gastroenterology VL - 146 IS - 3 N2 - BACKGROUND & AIMS: Reports on the association between dietary fiber intake and risk of colorectal adenoma (CRA), the precursor of colorectal cancer, have been inconsistent. We conducted a meta-analysis of case-control and cohort studies to analyze this association. METHODS: We searched the MEDLINE and EMBASE databases to identify relevant studies published through July 2013. A random-effects model was used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs) for associations between fiber intake and CRA risk. Heterogeneity among studies was assessed using the Cochran Q and I(2) statistics. RESULTS: Our meta-analysis included 20 studies involving 10,948 subjects with CRA. The SRRs of CRA for total dietary fiber were 0.72 (95% CI, 0.63-0.83) in a high- vs low-intake analysis and 0.91 (95% CI, 0.87-0.95) per 10-g/day increase in fiber intake in a dose-response model. Subgroup analyses indicated a significant inverse association between total fiber intake and CRA risk in case-control studies (SRR, 0.66; 95% CI, 0.56-0.77), but not in cohort studies (SRR, 0.92; 95% CI, 0.76-1.10). The SRRs of CRA were 0.84 for fruit fiber (95% CI, 0.76-0.94; n = 6 studies), 0.93 for vegetable fiber (95% CI, 0.84-1.04; n = 6 studies), and 0.76 for cereal fiber (95% CI, 0.62-0.92; n = 9 studies) in high- vs low-intake analyses. CONCLUSIONS: Our findings support the hypothesis that high dietary fiber intake is associated inversely with CRA risk. Further studies with prospective designs that use validated questionnaires and control for important confounders are warranted. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/24216326/Dietary_fiber_intake_reduces_risk_for_colorectal_adenoma:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(13)01586-2 DB - PRIME DP - Unbound Medicine ER -