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Abnormal default-mode network homogeneity in first-episode, drug-naive schizophrenia at rest.

Abstract

BACKGROUND

Dysconnectivity hypothesis posits that schizophrenia relates to abnormal resting-state connectivity within the default-mode network (DMN) and this aberrant connectivity is considered as contribution of difficulties in self-referential and introspective processing. However, little is known about the alterations of the network homogeneity (NH) of the DMN in schizophrenia. In the present study, we used an automatic NH method to investigate the NH of the DMN in schizophrenia patients at rest.

METHODS

Forty-nine first-episode, drug-naive schizophrenia patients and 50 age-, gender-, and education-matched healthy controls underwent a resting-state functional magnetic resonance imaging (fMRI). An automated NH approach was used to analyze the data.

RESULTS

Patients exhibited lower NH than controls in the left medial prefrontal cortex (MPFC) and the right middle temporal gyrus (MTG). Significantly higher NH values in the left posterior cingulate cortex (PCC) and the right cerebellum Crus I were found in the patient group than in the control group. No significant correlation was found between abnormal NH values and Positive and Negative Symptom Scale (PANSS) scores, duration of untreated psychosis (DUP), age or years of education in the patient group.

CONCLUSIONS

Our findings suggest that abnormal NH of the DMN exists in first-episode, drug-naive schizophrenia and further highlight the importance of the DMN in the pathophysiology of schizophrenia.

Authors+Show Affiliations

Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: guowenbin76@163.com.Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24216538

Citation

Guo, Wenbin, et al. "Abnormal Default-mode Network Homogeneity in First-episode, Drug-naive Schizophrenia at Rest." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 49, 2014, pp. 16-20.
Guo W, Yao D, Jiang J, et al. Abnormal default-mode network homogeneity in first-episode, drug-naive schizophrenia at rest. Prog Neuropsychopharmacol Biol Psychiatry. 2014;49:16-20.
Guo, W., Yao, D., Jiang, J., Su, Q., Zhang, Z., Zhang, J., ... Xiao, C. (2014). Abnormal default-mode network homogeneity in first-episode, drug-naive schizophrenia at rest. Progress in Neuro-psychopharmacology & Biological Psychiatry, 49, pp. 16-20. doi:10.1016/j.pnpbp.2013.10.021.
Guo W, et al. Abnormal Default-mode Network Homogeneity in First-episode, Drug-naive Schizophrenia at Rest. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:16-20. PubMed PMID: 24216538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal default-mode network homogeneity in first-episode, drug-naive schizophrenia at rest. AU - Guo,Wenbin, AU - Yao,Dapeng, AU - Jiang,Jiajing, AU - Su,Qinji, AU - Zhang,Zhikun, AU - Zhang,Jian, AU - Yu,Liuyu, AU - Xiao,Changqing, Y1 - 2013/11/09/ PY - 2013/09/24/received PY - 2013/10/28/revised PY - 2013/10/30/accepted PY - 2013/11/13/entrez PY - 2013/11/13/pubmed PY - 2015/1/1/medline KW - ACC KW - ADHD KW - DMN KW - DPARSF KW - DUP KW - Data Processing Assistant for Resting-State fMRI KW - Default mode network KW - FC KW - FMRI KW - FOV KW - GRF KW - Gaussian Random Field KW - IC KW - ICA KW - Independent component analysis KW - MPFC KW - MTG KW - NH KW - Network homogeneity KW - PANSS KW - PCC/Pcu KW - Positive and Negative Symptom Scale KW - ROI KW - Resting state KW - SCID KW - STG KW - Schizophrenia KW - Structured Clinical Interview of the DSM-IV KW - TR/TE KW - anterior cingulate cortex KW - attention-deficit/hyperactivity disorder KW - default mode network KW - duration of untreated psychosis KW - field of view KW - functional connectivity KW - functional magnetic resonance imaging KW - independent component KW - independent component analysis KW - medial prefrontal cortex KW - middle temporal gyrus KW - network homogeneity KW - posterior cingulate cortex/precuneus KW - region of interest KW - repetition time/echo time KW - superior temporal gyrus SP - 16 EP - 20 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 49 N2 - BACKGROUND: Dysconnectivity hypothesis posits that schizophrenia relates to abnormal resting-state connectivity within the default-mode network (DMN) and this aberrant connectivity is considered as contribution of difficulties in self-referential and introspective processing. However, little is known about the alterations of the network homogeneity (NH) of the DMN in schizophrenia. In the present study, we used an automatic NH method to investigate the NH of the DMN in schizophrenia patients at rest. METHODS: Forty-nine first-episode, drug-naive schizophrenia patients and 50 age-, gender-, and education-matched healthy controls underwent a resting-state functional magnetic resonance imaging (fMRI). An automated NH approach was used to analyze the data. RESULTS: Patients exhibited lower NH than controls in the left medial prefrontal cortex (MPFC) and the right middle temporal gyrus (MTG). Significantly higher NH values in the left posterior cingulate cortex (PCC) and the right cerebellum Crus I were found in the patient group than in the control group. No significant correlation was found between abnormal NH values and Positive and Negative Symptom Scale (PANSS) scores, duration of untreated psychosis (DUP), age or years of education in the patient group. CONCLUSIONS: Our findings suggest that abnormal NH of the DMN exists in first-episode, drug-naive schizophrenia and further highlight the importance of the DMN in the pathophysiology of schizophrenia. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/24216538/Abnormal_default_mode_network_homogeneity_in_first_episode_drug_naive_schizophrenia_at_rest_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(13)00243-1 DB - PRIME DP - Unbound Medicine ER -