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Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies.
J Feline Med Surg 2014; 16(6):465-72JF

Abstract

Chronic kidney disease (CKD) and degenerative joint disease are both considered common in older cats. Information on the co-prevalence of these two diseases is lacking. This retrospective study was designed to determine the prevalence of CKD in two cohorts of cats: cats randomly selected from four evenly distributed age groups (RS group) and cats recruited for degenerative joint disease studies (DJD group), and to evaluate the concurrence of CKD and DJD in these cohorts. The RS group was randomly selected from four age groups from 6 months to 20 years, and the DJD group comprised cats recruited to four previous DJD studies, with the DJD group excluding cats with a blood urea nitrogen and/or serum creatinine concentration >20% (the upper end of normal) for two studies and cats with CKD stages 3 and 4 for the other two studies. The prevalence of CKD in the RS and DJD groups was higher than expected at 50% and 68.8%, respectively. CKD was common in cats between 1 and 15 years of age, with a similar prevalence of CKD stages 1 and 2 across age groups in both the RS and DJD cats, respectively. We found significant concurrence between CKD and DJD in cats of all ages, indicating the need for increased screening for CKD when selecting DJD treatments. Additionally, this study offers the idea of a relationship and causal commonality between CKD and DJD owing to the striking concurrence across age groups and life stages.

Authors+Show Affiliations

Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA.Comparative Pain Research Laboratory, Surgery Section, Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, USA.Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, USA.Comparative Pain Research Laboratory, Surgery Section, Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA Comparative Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA.Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA steve_marks@ncsu.edu.

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24217707

Citation

Marino, Christina L., et al. "Prevalence and Classification of Chronic Kidney Disease in Cats Randomly Selected From Four Age Groups and in Cats Recruited for Degenerative Joint Disease Studies." Journal of Feline Medicine and Surgery, vol. 16, no. 6, 2014, pp. 465-72.
Marino CL, Lascelles BD, Vaden SL, et al. Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. J Feline Med Surg. 2014;16(6):465-72.
Marino, C. L., Lascelles, B. D., Vaden, S. L., Gruen, M. E., & Marks, S. L. (2014). Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. Journal of Feline Medicine and Surgery, 16(6), pp. 465-72. doi:10.1177/1098612X13511446.
Marino CL, et al. Prevalence and Classification of Chronic Kidney Disease in Cats Randomly Selected From Four Age Groups and in Cats Recruited for Degenerative Joint Disease Studies. J Feline Med Surg. 2014;16(6):465-72. PubMed PMID: 24217707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. AU - Marino,Christina L, AU - Lascelles,B Duncan X, AU - Vaden,Shelly L, AU - Gruen,Margaret E, AU - Marks,Steven L, Y1 - 2013/11/11/ PY - 2013/11/13/entrez PY - 2013/11/13/pubmed PY - 2015/7/3/medline SP - 465 EP - 72 JF - Journal of feline medicine and surgery JO - J. Feline Med. Surg. VL - 16 IS - 6 N2 - Chronic kidney disease (CKD) and degenerative joint disease are both considered common in older cats. Information on the co-prevalence of these two diseases is lacking. This retrospective study was designed to determine the prevalence of CKD in two cohorts of cats: cats randomly selected from four evenly distributed age groups (RS group) and cats recruited for degenerative joint disease studies (DJD group), and to evaluate the concurrence of CKD and DJD in these cohorts. The RS group was randomly selected from four age groups from 6 months to 20 years, and the DJD group comprised cats recruited to four previous DJD studies, with the DJD group excluding cats with a blood urea nitrogen and/or serum creatinine concentration >20% (the upper end of normal) for two studies and cats with CKD stages 3 and 4 for the other two studies. The prevalence of CKD in the RS and DJD groups was higher than expected at 50% and 68.8%, respectively. CKD was common in cats between 1 and 15 years of age, with a similar prevalence of CKD stages 1 and 2 across age groups in both the RS and DJD cats, respectively. We found significant concurrence between CKD and DJD in cats of all ages, indicating the need for increased screening for CKD when selecting DJD treatments. Additionally, this study offers the idea of a relationship and causal commonality between CKD and DJD owing to the striking concurrence across age groups and life stages. SN - 1532-2750 UR - https://www.unboundmedicine.com/medline/citation/24217707/Prevalence_and_classification_of_chronic_kidney_disease_in_cats_randomly_selected_from_four_age_groups_and_in_cats_recruited_for_degenerative_joint_disease_studies_ L2 - http://journals.sagepub.com/doi/full/10.1177/1098612X13511446?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -