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[Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats].
Zhong Yao Cai. 2013 May; 36(5):783-6.ZY

Abstract

OBJECTIVE

To compare the pharmacokinetics of gentiopicroside and Gentianae Radix extract in rats and assess the effect of other components in Gentianae Radix on the pharmacokinetics of gentiopicroside.

METHODS

The rats were oral administrated with gentiopicroside and Gentianae Radix extract, the content of geritiopicroside was chosen as index and determined by HPLC. The pharmacokinetic parameters were calculated with DAS 2.1.1 program.

RESULTS

The concentration-time curve of gentiopicroside and Gentianae Radix extract was described by two compartment model. The main pharmacokinetic parameters of gentiopicroside and Gentianae Radix extract were: C(max) (16.53 +/- 0.37) g/mL and (16.61 +/- 0.49) g/mL, T(max) 0.25 h and 1.5 h, t1/2(alpha) (0.20 +/- 0.04) h and (0.69 +/- 0. 14) h, t /2 (beta) (0.64 +/- 0.08) hand (0.80 +/- 0.11) h, AUC(0-infinity) (18.20 +/- 1.97) g x h/mL and (39.20 +/- 1.18) g x h/mL, CL(2.75 +/- 0.32) L/(h x kg) and (1.22 +/- 0.04) L (h x kg), respectively.

CONCLUSION

There are significantly differences in pharmacokinetic parameters between gentiopicroside and Gentianae Radix extract in rats.

Authors+Show Affiliations

Feng B
College of Pharmacy,Jilin Medical College, Jilin 132013, China. fengbo2@sina.com
Zhu HY
No affiliation info available
Guan J
No affiliation info available
Hao CY
No affiliation info available
Duan JC
No affiliation info available
Gu JK
No affiliation info available

MeSH

Administration, OralAnimalsArea Under CurveChromatography, High Pressure LiquidDrugs, Chinese HerbalGentianaceaeIridoid GlucosidesMalePlant RootsRatsRats, Wistar

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24218974

Citation

Feng, Bo, et al. "[Comparative Study On Pharmacokinetics of Gentiopicroside and Gentianae Radix Extract in Rats]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 36, no. 5, 2013, pp. 783-6.
Feng B, Zhu HY, Guan J, et al. [Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats]. Zhong Yao Cai. 2013;36(5):783-6.
Feng, B., Zhu, H. Y., Guan, J., Hao, C. Y., Duan, J. C., & Gu, J. K. (2013). [Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 36(5), 783-6.
Feng B, et al. [Comparative Study On Pharmacokinetics of Gentiopicroside and Gentianae Radix Extract in Rats]. Zhong Yao Cai. 2013;36(5):783-6. PubMed PMID: 24218974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats]. AU - Feng,Bo, AU - Zhu,He-Yun, AU - Guan,Jiao, AU - Hao,Cheng-Yi, AU - Duan,Jing-Can, AU - Gu,Jing-Kai, PY - 2013/11/14/entrez PY - 2013/11/14/pubmed PY - 2014/1/24/medline SP - 783 EP - 6 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 36 IS - 5 N2 - OBJECTIVE: To compare the pharmacokinetics of gentiopicroside and Gentianae Radix extract in rats and assess the effect of other components in Gentianae Radix on the pharmacokinetics of gentiopicroside. METHODS: The rats were oral administrated with gentiopicroside and Gentianae Radix extract, the content of geritiopicroside was chosen as index and determined by HPLC. The pharmacokinetic parameters were calculated with DAS 2.1.1 program. RESULTS: The concentration-time curve of gentiopicroside and Gentianae Radix extract was described by two compartment model. The main pharmacokinetic parameters of gentiopicroside and Gentianae Radix extract were: C(max) (16.53 +/- 0.37) g/mL and (16.61 +/- 0.49) g/mL, T(max) 0.25 h and 1.5 h, t1/2(alpha) (0.20 +/- 0.04) h and (0.69 +/- 0. 14) h, t /2 (beta) (0.64 +/- 0.08) hand (0.80 +/- 0.11) h, AUC(0-infinity) (18.20 +/- 1.97) g x h/mL and (39.20 +/- 1.18) g x h/mL, CL(2.75 +/- 0.32) L/(h x kg) and (1.22 +/- 0.04) L (h x kg), respectively. CONCLUSION: There are significantly differences in pharmacokinetic parameters between gentiopicroside and Gentianae Radix extract in rats. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/24218974/[Comparative_study_on_pharmacokinetics_of_gentiopicroside_and_gentianae_radix_extract_in_rats]_ DB - PRIME DP - Unbound Medicine ER -