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The association between serum vitamin D Level and disease activity in Thai rheumatoid arthritis patients.
Int J Rheum Dis. 2016 Apr; 19(4):355-61.IJ

Abstract

BACKGROUND

Serum vitamin D level was inversely associated with the risk of developing new onset rheumatoid arthritis (RA) and disease activity, but some conflicting results have been reported.

OBJECTIVE

To examine the serum vitamin D status in Thai RA patients and possible independent factors affecting serum 25 hydroxyvitamin vitamin D (25(OH)D) and the associations of serum 25(OH)D level and the disease activity and functional status in Thai RA patients.

METHODS

A cross-sectional study was performed in 239 Thai RA patients. The blood levels of 25(OH)D2 and D3 were measured by chemiluminescent immunoassay. Disease activity was assessed according to tender and swollen joint counts, erythrocyte sedimentation rate (ESR), visual analog scale for global patient assessment, Disease Activity Score-28 (DAS-28) and Thai Health Assessment Questionnaire (Thai HAQ).

RESULT

The mean vitamin D level was 28.79 ng/mL. There were no associations between 25(OH)D levels and number of tender and swollen joint counts, DAS-28 score, HAQ score or rheumatoid factor (RF) and/or anti-cyclic citrulinated peptide (CCP) positivity. After multivariated analysis, Bangkok residents, non-farmer, obesity and non-vitamin D supplementation were the predictors for vitamin D insufficiency in Thai patients with RA.

CONCLUSION

There are no associations of serum 25(OH)D levels with disease activity or functional status in Thai RA patients. The factors associated with vitamin D insufficiency are Bangkok resident, non-farmer, obesity and not taking vitamin D supplementation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Pakchotanon R
Rheumatic Disease Unit, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
Chaiamnuay S
Rheumatic Disease Unit, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
Narongroeknawin P
Rheumatic Disease Unit, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
Asavatanabodee P
Rheumatic Disease Unit, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.

MeSH

AgedArthritis, RheumatoidBiomarkersCross-Sectional StudiesDietary SupplementsFemaleHealth Status IndicatorsHumansImmunoassayMaleMiddle AgedObesityOccupationsPrevalenceProtective FactorsRisk FactorsSeverity of Illness IndexSurveys and QuestionnairesThailandUrban HealthVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24219063

Citation

Pakchotanon, Rattapol, et al. "The Association Between Serum Vitamin D Level and Disease Activity in Thai Rheumatoid Arthritis Patients." International Journal of Rheumatic Diseases, vol. 19, no. 4, 2016, pp. 355-61.
Pakchotanon R, Chaiamnuay S, Narongroeknawin P, et al. The association between serum vitamin D Level and disease activity in Thai rheumatoid arthritis patients. Int J Rheum Dis. 2016;19(4):355-61.
Pakchotanon, R., Chaiamnuay, S., Narongroeknawin, P., & Asavatanabodee, P. (2016). The association between serum vitamin D Level and disease activity in Thai rheumatoid arthritis patients. International Journal of Rheumatic Diseases, 19(4), 355-61. https://doi.org/10.1111/1756-185X.12222
Pakchotanon R, et al. The Association Between Serum Vitamin D Level and Disease Activity in Thai Rheumatoid Arthritis Patients. Int J Rheum Dis. 2016;19(4):355-61. PubMed PMID: 24219063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between serum vitamin D Level and disease activity in Thai rheumatoid arthritis patients. AU - Pakchotanon,Rattapol, AU - Chaiamnuay,Sumapa, AU - Narongroeknawin,Pongthorn, AU - Asavatanabodee,Paijit, Y1 - 2013/11/13/ PY - 2013/11/14/entrez PY - 2013/11/14/pubmed PY - 2017/5/10/medline KW - Thai KW - disease activity KW - obesity KW - rheumatoid arthritis KW - vitamin D SP - 355 EP - 61 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 19 IS - 4 N2 - BACKGROUND: Serum vitamin D level was inversely associated with the risk of developing new onset rheumatoid arthritis (RA) and disease activity, but some conflicting results have been reported. OBJECTIVE: To examine the serum vitamin D status in Thai RA patients and possible independent factors affecting serum 25 hydroxyvitamin vitamin D (25(OH)D) and the associations of serum 25(OH)D level and the disease activity and functional status in Thai RA patients. METHODS: A cross-sectional study was performed in 239 Thai RA patients. The blood levels of 25(OH)D2 and D3 were measured by chemiluminescent immunoassay. Disease activity was assessed according to tender and swollen joint counts, erythrocyte sedimentation rate (ESR), visual analog scale for global patient assessment, Disease Activity Score-28 (DAS-28) and Thai Health Assessment Questionnaire (Thai HAQ). RESULT: The mean vitamin D level was 28.79 ng/mL. There were no associations between 25(OH)D levels and number of tender and swollen joint counts, DAS-28 score, HAQ score or rheumatoid factor (RF) and/or anti-cyclic citrulinated peptide (CCP) positivity. After multivariated analysis, Bangkok residents, non-farmer, obesity and non-vitamin D supplementation were the predictors for vitamin D insufficiency in Thai patients with RA. CONCLUSION: There are no associations of serum 25(OH)D levels with disease activity or functional status in Thai RA patients. The factors associated with vitamin D insufficiency are Bangkok resident, non-farmer, obesity and not taking vitamin D supplementation. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/24219063/The_association_between_serum_vitamin_D_Level_and_disease_activity_in_Thai_rheumatoid_arthritis_patients_ DB - PRIME DP - Unbound Medicine ER -