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Cortical spreading depression and calcitonin gene-related peptide: a brief review of current progress.
Neuropeptides. 2013 Dec; 47(6):463-6.N

Abstract

Although detailed disease mechanisms of migraine remain poorly understood, migraine is known to have a complex pathophysiology with both vascular and neuronal mechanisms. The neuronal mechanisms of migraine may be attributed to cortical spreading depression (CSD); consequently, CSD has been widely studied for understanding the pathophysiology of migraine. Well validated CSD models have been developed for evaluating anti-migraine drugs. Neuropeptides, mainly, calcitonin gene-related peptide (CGRP), have been proposed as an emerging class of effective drugs against migraine headache. The central role of this neuropeptide has led to research into CSD for understanding disease mechanisms of migraine. This review briefly summarizes our current understanding of CSD and CGRP involvement in CSD. Although CSD can also worsen strokes, this brief paper has excluded the possible connection between the neuropeptide and CSD associated with them. Instead it has focused solely on CGRP in CSD associated with migraine.

Authors+Show Affiliations

Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou 215123, PR China. Electronic address: minyan.wang@xjtlu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24220568

Citation

Wang, Minyan. "Cortical Spreading Depression and Calcitonin Gene-related Peptide: a Brief Review of Current Progress." Neuropeptides, vol. 47, no. 6, 2013, pp. 463-6.
Wang M. Cortical spreading depression and calcitonin gene-related peptide: a brief review of current progress. Neuropeptides. 2013;47(6):463-6.
Wang, M. (2013). Cortical spreading depression and calcitonin gene-related peptide: a brief review of current progress. Neuropeptides, 47(6), 463-6. https://doi.org/10.1016/j.npep.2013.10.006
Wang M. Cortical Spreading Depression and Calcitonin Gene-related Peptide: a Brief Review of Current Progress. Neuropeptides. 2013;47(6):463-6. PubMed PMID: 24220568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortical spreading depression and calcitonin gene-related peptide: a brief review of current progress. A1 - Wang,Minyan, Y1 - 2013/10/23/ PY - 2013/09/19/received PY - 2013/10/11/revised PY - 2013/10/12/accepted PY - 2013/11/14/entrez PY - 2013/11/14/pubmed PY - 2014/7/11/medline KW - CGRP KW - Cortical spreading depression KW - Migraine KW - Neuropeptides SP - 463 EP - 6 JF - Neuropeptides JO - Neuropeptides VL - 47 IS - 6 N2 - Although detailed disease mechanisms of migraine remain poorly understood, migraine is known to have a complex pathophysiology with both vascular and neuronal mechanisms. The neuronal mechanisms of migraine may be attributed to cortical spreading depression (CSD); consequently, CSD has been widely studied for understanding the pathophysiology of migraine. Well validated CSD models have been developed for evaluating anti-migraine drugs. Neuropeptides, mainly, calcitonin gene-related peptide (CGRP), have been proposed as an emerging class of effective drugs against migraine headache. The central role of this neuropeptide has led to research into CSD for understanding disease mechanisms of migraine. This review briefly summarizes our current understanding of CSD and CGRP involvement in CSD. Although CSD can also worsen strokes, this brief paper has excluded the possible connection between the neuropeptide and CSD associated with them. Instead it has focused solely on CGRP in CSD associated with migraine. SN - 1532-2785 UR - https://www.unboundmedicine.com/medline/citation/24220568/Cortical_spreading_depression_and_calcitonin_gene_related_peptide:_a_brief_review_of_current_progress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4179(13)00072-3 DB - PRIME DP - Unbound Medicine ER -