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Perinatal outcomes after bariatric surgery: nationwide population based matched cohort study.
BMJ. 2013 Nov 12; 347:f6460.BMJ

Abstract

OBJECTIVE

To compare perinatal outcomes in births of women with versus without a history of bariatric surgery.

DESIGN

Population based matched cohort study.

SETTING

Swedish national health service.

PARTICIPANTS

1,742,702 singleton births identified in the Swedish medical birth register between 1992 and 2009. For each birth to a mother with a history of bariatric surgery (n=2562), up to five control births were matched by maternal age, parity, early pregnancy body mass index, early pregnancy smoking status, educational level, and year of delivery. Secondary control cohorts, including women eligible for bariatric surgery (body mass index ≥ 35 or ≥ 40), were matched for the same factors except body mass index. History of maternal bariatric surgery was ascertained through the Swedish national patient register from 1980 to 2009.

MAIN OUTCOME MEASURES

Preterm birth (<37 weeks), small for gestational age birth, large for gestational age birth, stillbirth (≥ 28 weeks), and neonatal death (0-27 days).

RESULTS

Post-surgery births were more often preterm than in matched controls (9.7% (243/2511) v 6.1% (750/12,379); odds ratio 1.7, 95% confidence interval 1.4 to 2.0; P<0.001). Body mass index seemed to be an effect modifier (P=0.01), and the increased risk of preterm birth was only observed in women with a body mass index <35. A history of bariatric surgery was associated with increased risks of both spontaneous (5.2% (130/2511) v 3.6% (441/12,379); odds ratio 1.5, 1.2 to 1.9; P<0.001) and medically indicated preterm birth (4.5% (113/2511) v 2.5% (309/12,379); odds ratio 1.8, 1.4 to 2.3; P<0.001). A history of bariatric surgery was also associated with an increased risk of a small for gestational age birth (5.2% (131/2507) v 3.0% (369/12,338); odds ratio 2.0, 1.5 to 2.5; P<0.001) and lower risk of a large for gestational age birth (4.2% (105/2507) v 7.3% (895/12,338); odds ratio 0.6, 0.4 to 0.7; P<0.001). No differences were detected for stillbirth or neonatal death. The increased risks for preterm and small for gestational age birth, as well as the decreased risk for large for gestational age birth, remained when post-surgery births were compared with births of women eligible for bariatric surgery.

CONCLUSION

Women with a history of bariatric surgery were at increased risk of preterm and small for gestational age births and should be regarded as a risk group during pregnancy.

Authors+Show Affiliations

Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24222480

Citation

Roos, Nathalie, et al. "Perinatal Outcomes After Bariatric Surgery: Nationwide Population Based Matched Cohort Study." BMJ (Clinical Research Ed.), vol. 347, 2013, pp. f6460.
Roos N, Neovius M, Cnattingius S, et al. Perinatal outcomes after bariatric surgery: nationwide population based matched cohort study. BMJ. 2013;347:f6460.
Roos, N., Neovius, M., Cnattingius, S., Trolle Lagerros, Y., Sääf, M., Granath, F., & Stephansson, O. (2013). Perinatal outcomes after bariatric surgery: nationwide population based matched cohort study. BMJ (Clinical Research Ed.), 347, f6460. https://doi.org/10.1136/bmj.f6460
Roos N, et al. Perinatal Outcomes After Bariatric Surgery: Nationwide Population Based Matched Cohort Study. BMJ. 2013 Nov 12;347:f6460. PubMed PMID: 24222480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal outcomes after bariatric surgery: nationwide population based matched cohort study. AU - Roos,Nathalie, AU - Neovius,Martin, AU - Cnattingius,Sven, AU - Trolle Lagerros,Ylva, AU - Sääf,Maria, AU - Granath,Fredrik, AU - Stephansson,Olof, Y1 - 2013/11/12/ PY - 2013/11/14/entrez PY - 2013/11/14/pubmed PY - 2014/1/7/medline SP - f6460 EP - f6460 JF - BMJ (Clinical research ed.) JO - BMJ VL - 347 N2 - OBJECTIVE: To compare perinatal outcomes in births of women with versus without a history of bariatric surgery. DESIGN: Population based matched cohort study. SETTING: Swedish national health service. PARTICIPANTS: 1,742,702 singleton births identified in the Swedish medical birth register between 1992 and 2009. For each birth to a mother with a history of bariatric surgery (n=2562), up to five control births were matched by maternal age, parity, early pregnancy body mass index, early pregnancy smoking status, educational level, and year of delivery. Secondary control cohorts, including women eligible for bariatric surgery (body mass index ≥ 35 or ≥ 40), were matched for the same factors except body mass index. History of maternal bariatric surgery was ascertained through the Swedish national patient register from 1980 to 2009. MAIN OUTCOME MEASURES: Preterm birth (<37 weeks), small for gestational age birth, large for gestational age birth, stillbirth (≥ 28 weeks), and neonatal death (0-27 days). RESULTS: Post-surgery births were more often preterm than in matched controls (9.7% (243/2511) v 6.1% (750/12,379); odds ratio 1.7, 95% confidence interval 1.4 to 2.0; P<0.001). Body mass index seemed to be an effect modifier (P=0.01), and the increased risk of preterm birth was only observed in women with a body mass index <35. A history of bariatric surgery was associated with increased risks of both spontaneous (5.2% (130/2511) v 3.6% (441/12,379); odds ratio 1.5, 1.2 to 1.9; P<0.001) and medically indicated preterm birth (4.5% (113/2511) v 2.5% (309/12,379); odds ratio 1.8, 1.4 to 2.3; P<0.001). A history of bariatric surgery was also associated with an increased risk of a small for gestational age birth (5.2% (131/2507) v 3.0% (369/12,338); odds ratio 2.0, 1.5 to 2.5; P<0.001) and lower risk of a large for gestational age birth (4.2% (105/2507) v 7.3% (895/12,338); odds ratio 0.6, 0.4 to 0.7; P<0.001). No differences were detected for stillbirth or neonatal death. The increased risks for preterm and small for gestational age birth, as well as the decreased risk for large for gestational age birth, remained when post-surgery births were compared with births of women eligible for bariatric surgery. CONCLUSION: Women with a history of bariatric surgery were at increased risk of preterm and small for gestational age births and should be regarded as a risk group during pregnancy. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/24222480/Perinatal_outcomes_after_bariatric_surgery:_nationwide_population_based_matched_cohort_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&amp;pmid=24222480 DB - PRIME DP - Unbound Medicine ER -