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Potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease.
World J Gastroenterol. 2013 Nov 07; 19(41):7024-31.WJ

Abstract

Accumulating evidence has implicated Helicobacter pylori (H. pylori) infection in extragastrointestinal diseases, including obesity, type 2 diabetes mellitus, cardiovascular disease, and liver disease. Recently, there has been a special focus on H. pylori infection as a risk factor for the development of nonalcoholic fatty liver disease (NAFLD). NAFLD is currently considered to be the most common liver disorder in western countries, and is rapidly becoming a serious threat to public health. The mechanisms of pathogenesis underlying NAFLD remain unclear at present and therapeutic options are limited. The growing awareness of the role of H. pylori in NAFLD is thus important to aid the development of novel intervention and prevention strategies, because the eradication of H. pylori is easy and much less expensive than long-term treatment of the other risk factors. H. pylori infection is involved in the pathogenesis of insulin resistance (IR), which is closely linked with NAFLD. It provides a new insight into the pathogenesis of NAFLD. This review probes the possible relationship between H. pylori and NAFLD, from the perspective of the potential mechanism of how H. pylori infection brings about IR and other aspects concerning this correlation.

Authors+Show Affiliations

Meng Li, Zhe Shen, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24222944

Citation

Li, Meng, et al. "Potential Role of Helicobacter Pylori Infection in Nonalcoholic Fatty Liver Disease." World Journal of Gastroenterology, vol. 19, no. 41, 2013, pp. 7024-31.
Li M, Shen Z, Li YM. Potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease. World J Gastroenterol. 2013;19(41):7024-31.
Li, M., Shen, Z., & Li, Y. M. (2013). Potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease. World Journal of Gastroenterology, 19(41), 7024-31. https://doi.org/10.3748/wjg.v19.i41.7024
Li M, Shen Z, Li YM. Potential Role of Helicobacter Pylori Infection in Nonalcoholic Fatty Liver Disease. World J Gastroenterol. 2013 Nov 7;19(41):7024-31. PubMed PMID: 24222944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease. AU - Li,Meng, AU - Shen,Zhe, AU - Li,You-Ming, PY - 2013/07/30/received PY - 2013/09/05/revised PY - 2013/09/15/accepted PY - 2013/11/14/entrez PY - 2013/11/14/pubmed PY - 2014/4/12/medline KW - Cytokines KW - Helicobacter pylori KW - Inflammation KW - Insulin resistance KW - Nonalcoholic fatty liver disease SP - 7024 EP - 31 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 19 IS - 41 N2 - Accumulating evidence has implicated Helicobacter pylori (H. pylori) infection in extragastrointestinal diseases, including obesity, type 2 diabetes mellitus, cardiovascular disease, and liver disease. Recently, there has been a special focus on H. pylori infection as a risk factor for the development of nonalcoholic fatty liver disease (NAFLD). NAFLD is currently considered to be the most common liver disorder in western countries, and is rapidly becoming a serious threat to public health. The mechanisms of pathogenesis underlying NAFLD remain unclear at present and therapeutic options are limited. The growing awareness of the role of H. pylori in NAFLD is thus important to aid the development of novel intervention and prevention strategies, because the eradication of H. pylori is easy and much less expensive than long-term treatment of the other risk factors. H. pylori infection is involved in the pathogenesis of insulin resistance (IR), which is closely linked with NAFLD. It provides a new insight into the pathogenesis of NAFLD. This review probes the possible relationship between H. pylori and NAFLD, from the perspective of the potential mechanism of how H. pylori infection brings about IR and other aspects concerning this correlation. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24222944/Potential_role_of_Helicobacter_pylori_infection_in_nonalcoholic_fatty_liver_disease_ L2 - https://www.wjgnet.com/1007-9327/full/v19/i41/7024.htm DB - PRIME DP - Unbound Medicine ER -