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A severe course of Cronkhite-Canada syndrome and the review of clinical features and therapy in 49 Chinese patients.
Turk J Gastroenterol. 2013; 24(3):277-85.TJ

Abstract

We describe a severe case of Cronkhite-Canada syndrome and review the clinical features and therapy in 49 Chinese patients. A 67-year-old man who underwent severe chronic diarrhea had typical clinical manifestations of hyperpigmentation, hair loss, and dystrophic changes in the fingernails. Although sufficient nutrition support and other therapies reported in the literature were provided, the patient died of systemic failure one year later. Cronkhite-Canada syndrome is characterized by generalized gastrointestinal polyps associated with hyperpigmentation, hair loss, and onycholysis. Anemia, positive stool occult blood, serum electrolyte disturbances, and low serum proteins are the main clinical features of patients with Cronkhite-Canada syndrome. Most patients were diagnosed by esophagogastroduodenoscopy and/or colonoscopy, and polyps were found in the entire alimentary tract, except the notable exception of the esophagus. The polyp-like samples of mucosa, hyperplasia, and adenoma were characterized by acute/chronic inflammation. Four cases were complicated with cancer. The treatment of Cronkhite-Canada syndrome includes symptomatic and support therapy, administration of corticosteroids, antibiotics and acid inhibitors, therapeutic endoscopy, and surgery. While the mortality rate was reported as 47.3% (9/19), some patients may live a long life with controlled symptoms.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

24226722

Citation

She, Qiang, et al. "A Severe Course of Cronkhite-Canada Syndrome and the Review of Clinical Features and Therapy in 49 Chinese Patients." The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, vol. 24, no. 3, 2013, pp. 277-85.
She Q, Jiang JX, Si XM, et al. A severe course of Cronkhite-Canada syndrome and the review of clinical features and therapy in 49 Chinese patients. Turk J Gastroenterol. 2013;24(3):277-85.
She, Q., Jiang, J. X., Si, X. M., Tian, X. Y., Shi, R. H., & Zhang, G. X. (2013). A severe course of Cronkhite-Canada syndrome and the review of clinical features and therapy in 49 Chinese patients. The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, 24(3), 277-85.
She Q, et al. A Severe Course of Cronkhite-Canada Syndrome and the Review of Clinical Features and Therapy in 49 Chinese Patients. Turk J Gastroenterol. 2013;24(3):277-85. PubMed PMID: 24226722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A severe course of Cronkhite-Canada syndrome and the review of clinical features and therapy in 49 Chinese patients. AU - She,Qiang, AU - Jiang,Jian-Xia, AU - Si,Xin-Min, AU - Tian,Xue-Ying, AU - Shi,Rui-Hua, AU - Zhang,Guo-Xin, PY - 2013/11/15/entrez PY - 2013/11/15/pubmed PY - 2014/11/7/medline SP - 277 EP - 85 JF - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JO - Turk J Gastroenterol VL - 24 IS - 3 N2 - We describe a severe case of Cronkhite-Canada syndrome and review the clinical features and therapy in 49 Chinese patients. A 67-year-old man who underwent severe chronic diarrhea had typical clinical manifestations of hyperpigmentation, hair loss, and dystrophic changes in the fingernails. Although sufficient nutrition support and other therapies reported in the literature were provided, the patient died of systemic failure one year later. Cronkhite-Canada syndrome is characterized by generalized gastrointestinal polyps associated with hyperpigmentation, hair loss, and onycholysis. Anemia, positive stool occult blood, serum electrolyte disturbances, and low serum proteins are the main clinical features of patients with Cronkhite-Canada syndrome. Most patients were diagnosed by esophagogastroduodenoscopy and/or colonoscopy, and polyps were found in the entire alimentary tract, except the notable exception of the esophagus. The polyp-like samples of mucosa, hyperplasia, and adenoma were characterized by acute/chronic inflammation. Four cases were complicated with cancer. The treatment of Cronkhite-Canada syndrome includes symptomatic and support therapy, administration of corticosteroids, antibiotics and acid inhibitors, therapeutic endoscopy, and surgery. While the mortality rate was reported as 47.3% (9/19), some patients may live a long life with controlled symptoms. SN - 2148-5607 UR - https://www.unboundmedicine.com/medline/citation/24226722/A_severe_course_of_Cronkhite_Canada_syndrome_and_the_review_of_clinical_features_and_therapy_in_49_Chinese_patients_ L2 - http://www.turkjgastroenterol.org/eng/makale/2757/199/Full-Text DB - PRIME DP - Unbound Medicine ER -