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Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac.
Saudi Pharm J. 2013 Oct; 21(4):387-97.SP

Abstract

The aim of this study was to synthesize and evaluate novel biodegradable polyesters namely; poly(ethylene glycol)-Poly(glycerol adipate-co-ω-pentadecalactone), PEG-PGA-co-PDL-PEG, and poly(ethylene glycol methyl ether)-Poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL-PEGme as an alternative sustained release carrier for lung delivery compared with non-PEG containing polymer PGA-co-PDL. The co-polymers were synthesized through lipase catalysis ring opening polymerization reaction and characterized using GPC, FT-IR, (1)H-NMR and surface contact angle. Furthermore, microparticles containing a model hydrophilic drug, sodium diclofenac, were prepared via spray drying from a modified single emulsion and characterized for their encapsulation efficiency, geometrical particle size, zeta potential, tapped density, primary aerodynamic diameter, amorphous nature, morphology, in vitro release and the aerosolization performance. Microparticles fabricated from mPEG-co-polymer can be targeted to the lung periphery with an optimum in vitro deposition. Furthermore, a significantly higher in vitro release (p > 0.05, ANOVA/Dunnett's) was observed with the PEG and mPEG-co-polymers compared to PGA-co-PDL. In addition, these co-polymers have a good safety profile upon testing on human bronchial epithelial, 16HBE14o- cell lines.

Authors+Show Affiliations

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24227959

Citation

Tawfeek, Hesham M.. "Evaluation of PEG and mPEG-co-(PGA-co-PDL) Microparticles Loaded With Sodium Diclofenac." Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society, vol. 21, no. 4, 2013, pp. 387-97.
Tawfeek HM. Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac. Saudi Pharm J. 2013;21(4):387-97.
Tawfeek, H. M. (2013). Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac. Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society, 21(4), 387-97. https://doi.org/10.1016/j.jsps.2012.11.006
Tawfeek HM. Evaluation of PEG and mPEG-co-(PGA-co-PDL) Microparticles Loaded With Sodium Diclofenac. Saudi Pharm J. 2013;21(4):387-97. PubMed PMID: 24227959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac. A1 - Tawfeek,Hesham M, PY - 2013/11/15/entrez PY - 2013/11/15/pubmed PY - 2013/11/15/medline KW - Lung delivery KW - Microparticles KW - PEG-co-polymers KW - PGA-co-PDL KW - Sodium diclofenac SP - 387 EP - 97 JF - Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society JO - Saudi Pharm J VL - 21 IS - 4 N2 - The aim of this study was to synthesize and evaluate novel biodegradable polyesters namely; poly(ethylene glycol)-Poly(glycerol adipate-co-ω-pentadecalactone), PEG-PGA-co-PDL-PEG, and poly(ethylene glycol methyl ether)-Poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL-PEGme as an alternative sustained release carrier for lung delivery compared with non-PEG containing polymer PGA-co-PDL. The co-polymers were synthesized through lipase catalysis ring opening polymerization reaction and characterized using GPC, FT-IR, (1)H-NMR and surface contact angle. Furthermore, microparticles containing a model hydrophilic drug, sodium diclofenac, were prepared via spray drying from a modified single emulsion and characterized for their encapsulation efficiency, geometrical particle size, zeta potential, tapped density, primary aerodynamic diameter, amorphous nature, morphology, in vitro release and the aerosolization performance. Microparticles fabricated from mPEG-co-polymer can be targeted to the lung periphery with an optimum in vitro deposition. Furthermore, a significantly higher in vitro release (p > 0.05, ANOVA/Dunnett's) was observed with the PEG and mPEG-co-polymers compared to PGA-co-PDL. In addition, these co-polymers have a good safety profile upon testing on human bronchial epithelial, 16HBE14o- cell lines. SN - 1319-0164 UR - https://www.unboundmedicine.com/medline/citation/24227959/Evaluation_of_PEG_and_mPEG_co__PGA_co_PDL__microparticles_loaded_with_sodium_diclofenac_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1319-0164(12)00102-8 DB - PRIME DP - Unbound Medicine ER -
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