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Cranberries and their bioactive constituents in human health.

Abstract

Recent observational and clinical studies have raised interest in the potential health effects of cranberry consumption, an association that appears to be due to the phytochemical content of this fruit. The profile of cranberry bioactives is distinct from that of other berry fruit, being rich in A-type proanthocyanidins (PACs) in contrast to the B-type PACs present in most other fruit. Basic research has suggested a number of potential mechanisms of action of cranberry bioactives, although further molecular studies are necessary. Human studies on the health effects of cranberry products have focused principally on urinary tract and cardiovascular health, with some attention also directed to oral health and gastrointestinal epithelia. Evidence suggesting that cranberries may decrease the recurrence of urinary tract infections is important because a nutritional approach to this condition could lower the use of antibiotic treatment and the consequent development of resistance to these drugs. There is encouraging, but limited, evidence of a cardioprotective effect of cranberries mediated via actions on antioxidant capacity and lipoprotein profiles. The mixed outcomes from clinical studies with cranberry products could result from interventions testing a variety of products, often uncharacterized in their composition of bioactives, using different doses and regimens, as well as the absence of a biomarker for compliance to the protocol. Daily consumption of a variety of fruit is necessary to achieve a healthy dietary pattern, meet recommendations for micronutrient intake, and promote the intake of a diversity of phytochemicals. Berry fruit, including cranberries, represent a rich source of phenolic bioactives that may contribute to human health.

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  • Authors+Show Affiliations

    ,

    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.

    , , , , , , , ,

    Source

    MeSH

    Antioxidants
    Cardiovascular Diseases
    Diet
    Fruit
    Humans
    Phenols
    Phytotherapy
    Plant Extracts
    Proanthocyanidins
    Urinary Tract Infections
    Vaccinium macrocarpon

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    24228191

    Citation

    Blumberg, Jeffrey B., et al. "Cranberries and Their Bioactive Constituents in Human Health." Advances in Nutrition (Bethesda, Md.), vol. 4, no. 6, 2013, pp. 618-32.
    Blumberg JB, Camesano TA, Cassidy A, et al. Cranberries and their bioactive constituents in human health. Adv Nutr. 2013;4(6):618-32.
    Blumberg, J. B., Camesano, T. A., Cassidy, A., Kris-Etherton, P., Howell, A., Manach, C., ... Vita, J. A. (2013). Cranberries and their bioactive constituents in human health. Advances in Nutrition (Bethesda, Md.), 4(6), pp. 618-32. doi:10.3945/an.113.004473.
    Blumberg JB, et al. Cranberries and Their Bioactive Constituents in Human Health. Adv Nutr. 2013;4(6):618-32. PubMed PMID: 24228191.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cranberries and their bioactive constituents in human health. AU - Blumberg,Jeffrey B, AU - Camesano,Terri A, AU - Cassidy,Aedin, AU - Kris-Etherton,Penny, AU - Howell,Amy, AU - Manach,Claudine, AU - Ostertag,Luisa M, AU - Sies,Helmut, AU - Skulas-Ray,Ann, AU - Vita,Joseph A, Y1 - 2013/11/06/ PY - 2013/11/15/entrez PY - 2013/11/15/pubmed PY - 2014/6/10/medline SP - 618 EP - 32 JF - Advances in nutrition (Bethesda, Md.) JO - Adv Nutr VL - 4 IS - 6 N2 - Recent observational and clinical studies have raised interest in the potential health effects of cranberry consumption, an association that appears to be due to the phytochemical content of this fruit. The profile of cranberry bioactives is distinct from that of other berry fruit, being rich in A-type proanthocyanidins (PACs) in contrast to the B-type PACs present in most other fruit. Basic research has suggested a number of potential mechanisms of action of cranberry bioactives, although further molecular studies are necessary. Human studies on the health effects of cranberry products have focused principally on urinary tract and cardiovascular health, with some attention also directed to oral health and gastrointestinal epithelia. Evidence suggesting that cranberries may decrease the recurrence of urinary tract infections is important because a nutritional approach to this condition could lower the use of antibiotic treatment and the consequent development of resistance to these drugs. There is encouraging, but limited, evidence of a cardioprotective effect of cranberries mediated via actions on antioxidant capacity and lipoprotein profiles. The mixed outcomes from clinical studies with cranberry products could result from interventions testing a variety of products, often uncharacterized in their composition of bioactives, using different doses and regimens, as well as the absence of a biomarker for compliance to the protocol. Daily consumption of a variety of fruit is necessary to achieve a healthy dietary pattern, meet recommendations for micronutrient intake, and promote the intake of a diversity of phytochemicals. Berry fruit, including cranberries, represent a rich source of phenolic bioactives that may contribute to human health. SN - 2156-5376 UR - https://www.unboundmedicine.com/medline/citation/24228191/Cranberries_and_their_bioactive_constituents_in_human_health_ L2 - https://academic.oup.com/advances/article-lookup/doi/10.3945/an.113.004473 DB - PRIME DP - Unbound Medicine ER -