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Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways.
Integr Cancer Ther 2014; 13(3):240-8IC

Abstract

The pathogenic mechanisms underlying cancer development are complex and heterogeneous, involving multiple cellular signaling transduction pathways that usually function redundantly. In addition, crosstalk between these pathways generates a complicated and robust signaling network that is regulated by compensatory mechanisms. Given the complexity of cancer pathogenesis and progression, many of the currently used antitumor agents, which typically target a single intracellular pathway, might not always be effective on complex tumor systems. Moreover, long-term use of these agents often generates drug resistance and toxicity against normal cells. Therefore, the development of novel anticancer chemotherapies is urgently needed.Scutellaria barbataD Don (SB) is a medicinal herb that has long been used in China to treat various types of cancer. We previously reported that the ethanol extract of SB (EESB) is able to induce colon cancer cell apoptosis, inhibit cell proliferation and tumor angiogenesis via modulation of several pathways, including Hedgehog, Akt, and p53. To further elucidate the precise mechanisms of SB's antitumor activity, using a colorectal cancer (CRC) mouse xenograft model in the present study, we evaluated the therapeutic efficacy and molecular mechanisms of EESB against tumor growth. We found that EESB reduced tumor volume and tumor weight but had no effect on body weight gain in CRC mice, demonstrating that EESB could inhibit colon cancer growth in vivo without apparent adverse effect. In addition, EESB treatment could significantly suppress the activation of several CRC-related pathways, including STAT3, Erk, and p38 signalings in tumor tissues, and alter the expression of multiple critical target genes such as Bcl-2, Bax, Cyclin D1, CDK4, and p21. These molecular effects lead to the induction of cancer cell apoptosis and inhibition of cell proliferation. Our findings demonstrate that SB possesses a broad range of antitumor activities because of its ability to affect multiple intracellular targets.

Authors+Show Affiliations

Fujian University of Traditional Chinese Medicine, Fujian, China.Case Western Reserve University School of Medicine, Rainbow Babies & Children's Hospital, Cleveland, OH, USA.Fujian University of Traditional Chinese Medicine, Fujian, China.Fujian University of Traditional Chinese Medicine, Fujian, China.Fujian University of Traditional Chinese Medicine, Fujian, China.Fujian University of Traditional Chinese Medicine, Fujian, China.Case Western Reserve University School of Medicine, Rainbow Babies & Children's Hospital, Cleveland, OH, USA.Fujian University of Traditional Chinese Medicine, Fujian, China pjunlab@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24231788

Citation

Lin, Jiumao, et al. "Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth Via Suppression of Multiple Signaling Pathways." Integrative Cancer Therapies, vol. 13, no. 3, 2014, pp. 240-8.
Lin J, Chen Y, Cai Q, et al. Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways. Integr Cancer Ther. 2014;13(3):240-8.
Lin, J., Chen, Y., Cai, Q., Wei, L., Zhan, Y., Shen, A., ... Peng, J. (2014). Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways. Integrative Cancer Therapies, 13(3), pp. 240-8. doi:10.1177/1534735413508811.
Lin J, et al. Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth Via Suppression of Multiple Signaling Pathways. Integr Cancer Ther. 2014;13(3):240-8. PubMed PMID: 24231788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways. AU - Lin,Jiumao, AU - Chen,Youqin, AU - Cai,Qiaoyan, AU - Wei,Lihui, AU - Zhan,Youzhi, AU - Shen,Aling, AU - Sferra,Thomas J, AU - Peng,Jun, Y1 - 2013/11/13/ PY - 2013/11/16/entrez PY - 2013/11/16/pubmed PY - 2016/12/15/medline KW - Scutellaria barbata D Don KW - anticancer KW - apoptosis KW - colorectal cancer KW - proliferation KW - signaling pathway SP - 240 EP - 8 JF - Integrative cancer therapies JO - Integr Cancer Ther VL - 13 IS - 3 N2 - The pathogenic mechanisms underlying cancer development are complex and heterogeneous, involving multiple cellular signaling transduction pathways that usually function redundantly. In addition, crosstalk between these pathways generates a complicated and robust signaling network that is regulated by compensatory mechanisms. Given the complexity of cancer pathogenesis and progression, many of the currently used antitumor agents, which typically target a single intracellular pathway, might not always be effective on complex tumor systems. Moreover, long-term use of these agents often generates drug resistance and toxicity against normal cells. Therefore, the development of novel anticancer chemotherapies is urgently needed.Scutellaria barbataD Don (SB) is a medicinal herb that has long been used in China to treat various types of cancer. We previously reported that the ethanol extract of SB (EESB) is able to induce colon cancer cell apoptosis, inhibit cell proliferation and tumor angiogenesis via modulation of several pathways, including Hedgehog, Akt, and p53. To further elucidate the precise mechanisms of SB's antitumor activity, using a colorectal cancer (CRC) mouse xenograft model in the present study, we evaluated the therapeutic efficacy and molecular mechanisms of EESB against tumor growth. We found that EESB reduced tumor volume and tumor weight but had no effect on body weight gain in CRC mice, demonstrating that EESB could inhibit colon cancer growth in vivo without apparent adverse effect. In addition, EESB treatment could significantly suppress the activation of several CRC-related pathways, including STAT3, Erk, and p38 signalings in tumor tissues, and alter the expression of multiple critical target genes such as Bcl-2, Bax, Cyclin D1, CDK4, and p21. These molecular effects lead to the induction of cancer cell apoptosis and inhibition of cell proliferation. Our findings demonstrate that SB possesses a broad range of antitumor activities because of its ability to affect multiple intracellular targets. SN - 1552-695X UR - https://www.unboundmedicine.com/medline/citation/24231788/Scutellaria_Barbata_D_Don_Inhibits_Colorectal_Cancer_Growth_via_Suppression_of_Multiple_Signaling_Pathways_ L2 - http://journals.sagepub.com/doi/full/10.1177/1534735413508811?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -