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Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology.
Life Sci. 2014 Feb 27; 97(1):20-6.LS

Abstract

This mini-review summarizes the history of cathinone and its synthesized derivatives from early records to the present day, including the appearance of synthetic cathinones in the drug combination known as bath salts. Bath salts may consist of one compound (MDPV) or combinations of MDPV and one or more other synthetic cathinones, which may also appear alone without MDPV. We briefly review recent in vitro studies of bath salts components alone or in combination, focusing on pharmacological and biophysical studies. Finally we summarize new data from in vivo procedures that characterize the abuse-related neurochemical and behavioral effects of synthetic cathinones in rats.

Authors+Show Affiliations

Department of Physiology and Biophysics, School of Medicine, USA. Electronic address: ljdefelice@vcu.edu.Department of Medicinal Chemistry, School of Pharmacy, USA.Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

24231923

Citation

De Felice, Louis J., et al. "Synthetic Cathinones: Chemical Phylogeny, Physiology, and Neuropharmacology." Life Sciences, vol. 97, no. 1, 2014, pp. 20-6.
De Felice LJ, Glennon RA, Negus SS. Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology. Life Sci. 2014;97(1):20-6.
De Felice, L. J., Glennon, R. A., & Negus, S. S. (2014). Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology. Life Sciences, 97(1), 20-6. https://doi.org/10.1016/j.lfs.2013.10.029
De Felice LJ, Glennon RA, Negus SS. Synthetic Cathinones: Chemical Phylogeny, Physiology, and Neuropharmacology. Life Sci. 2014 Feb 27;97(1):20-6. PubMed PMID: 24231923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology. AU - De Felice,Louis J, AU - Glennon,Richard A, AU - Negus,Sidney S, Y1 - 2013/11/11/ PY - 2013/06/28/received PY - 2013/10/22/revised PY - 2013/10/25/accepted PY - 2013/11/16/entrez PY - 2013/11/16/pubmed PY - 2014/4/16/medline KW - Amphetamine KW - Bath salts KW - Cocaine KW - Dopamine KW - Intracranial selfstimulation (ICSS) KW - MDPV KW - Mephedrone KW - Methamphamine KW - Methcathinone KW - Methylone KW - Serotonin KW - Synthetic cathinones KW - Transporters SP - 20 EP - 6 JF - Life sciences JO - Life Sci. VL - 97 IS - 1 N2 - This mini-review summarizes the history of cathinone and its synthesized derivatives from early records to the present day, including the appearance of synthetic cathinones in the drug combination known as bath salts. Bath salts may consist of one compound (MDPV) or combinations of MDPV and one or more other synthetic cathinones, which may also appear alone without MDPV. We briefly review recent in vitro studies of bath salts components alone or in combination, focusing on pharmacological and biophysical studies. Finally we summarize new data from in vivo procedures that characterize the abuse-related neurochemical and behavioral effects of synthetic cathinones in rats. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/24231923/Synthetic_cathinones:_chemical_phylogeny_physiology_and_neuropharmacology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(13)00661-9 DB - PRIME DP - Unbound Medicine ER -