Tags

Type your tag names separated by a space and hit enter

The association between biomarkers in cerebrospinal fluid and structural changes in the brain in patients with Alzheimer's disease.
J Intern Med. 2014 Apr; 275(4):418-27.JI

Abstract

BACKGROUND

Biochemical changes in the cerebrospinal fluid (CSF) could reflect pathophysiological processes in Alzheimer's disease (AD). However, it is still not clear how these processes correlate with grey matter (GM) volume and microstructural changes in the brain.

OBJECTIVE

To assess the relationship between CSF biomarkers and structural brain changes in AD.

DESIGN AND SETTING

Cross-sectional study in a memory clinic-based sample.

SUBJECTS

A total of 78 subjects were included in the study: 22 with subjective cognitive impairment (SCI), 35 with mild cognitive impairment (MCI) and 21 with AD.

MAIN OUTCOME MEASURES

Voxel-wise correlations between CSF biomarkers, including β-amyloid42 (Aβ42), tau phosphorylated at position threonine 181 and total tau protein, and GM volume, self-diffusion fractional anisotropy (FA) and mean diffusivity (MD) maps using voxel-based morphometry and tract-based spatial statistical analyses. FA and MD maps were obtained using diffusion tensor imaging.

RESULTS

In the whole sample (patients with SCI, MCI and AD), there was positive correlation between GM volume and Aβ42 concentration, and negative correlation with total tau protein. Higher FA was only related to higher concentration of Aβ42. MD showed significant negative correlation with Aβ42 and positive correlation with T-tau levels. The majority of brain regions with significant correlation with CSF biomarkers overlapped with the default mode network and extended to the adjacent white matter.

CONCLUSIONS

Early AD pathological changes can be detected with voxel-based morphometric analysis and diffusion tensor imaging measurements. Furthermore, there was an association between CSF AD biomarkers and structural brain changes in areas related to the default mode network.

Authors+Show Affiliations

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24237038

Citation

Li, X, et al. "The Association Between Biomarkers in Cerebrospinal Fluid and Structural Changes in the Brain in Patients With Alzheimer's Disease." Journal of Internal Medicine, vol. 275, no. 4, 2014, pp. 418-27.
Li X, Li TQ, Andreasen N, et al. The association between biomarkers in cerebrospinal fluid and structural changes in the brain in patients with Alzheimer's disease. J Intern Med. 2014;275(4):418-27.
Li, X., Li, T. Q., Andreasen, N., Wiberg, M. K., Westman, E., & Wahlund, L. O. (2014). The association between biomarkers in cerebrospinal fluid and structural changes in the brain in patients with Alzheimer's disease. Journal of Internal Medicine, 275(4), 418-27. https://doi.org/10.1111/joim.12164
Li X, et al. The Association Between Biomarkers in Cerebrospinal Fluid and Structural Changes in the Brain in Patients With Alzheimer's Disease. J Intern Med. 2014;275(4):418-27. PubMed PMID: 24237038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between biomarkers in cerebrospinal fluid and structural changes in the brain in patients with Alzheimer's disease. AU - Li,X, AU - Li,T-Q, AU - Andreasen,N, AU - Wiberg,M K, AU - Westman,E, AU - Wahlund,L-O, Y1 - 2013/12/11/ PY - 2013/11/19/entrez PY - 2013/11/19/pubmed PY - 2014/6/4/medline KW - Alzheimer's disease (AD) KW - cerebrospinal fluid biomarkers KW - diffusion tensor imaging (DTI) KW - fractional anisotropy (FA) KW - grey matter (GM) KW - mean diffusivity (MD) SP - 418 EP - 27 JF - Journal of internal medicine JO - J Intern Med VL - 275 IS - 4 N2 - BACKGROUND: Biochemical changes in the cerebrospinal fluid (CSF) could reflect pathophysiological processes in Alzheimer's disease (AD). However, it is still not clear how these processes correlate with grey matter (GM) volume and microstructural changes in the brain. OBJECTIVE: To assess the relationship between CSF biomarkers and structural brain changes in AD. DESIGN AND SETTING: Cross-sectional study in a memory clinic-based sample. SUBJECTS: A total of 78 subjects were included in the study: 22 with subjective cognitive impairment (SCI), 35 with mild cognitive impairment (MCI) and 21 with AD. MAIN OUTCOME MEASURES: Voxel-wise correlations between CSF biomarkers, including β-amyloid42 (Aβ42), tau phosphorylated at position threonine 181 and total tau protein, and GM volume, self-diffusion fractional anisotropy (FA) and mean diffusivity (MD) maps using voxel-based morphometry and tract-based spatial statistical analyses. FA and MD maps were obtained using diffusion tensor imaging. RESULTS: In the whole sample (patients with SCI, MCI and AD), there was positive correlation between GM volume and Aβ42 concentration, and negative correlation with total tau protein. Higher FA was only related to higher concentration of Aβ42. MD showed significant negative correlation with Aβ42 and positive correlation with T-tau levels. The majority of brain regions with significant correlation with CSF biomarkers overlapped with the default mode network and extended to the adjacent white matter. CONCLUSIONS: Early AD pathological changes can be detected with voxel-based morphometric analysis and diffusion tensor imaging measurements. Furthermore, there was an association between CSF AD biomarkers and structural brain changes in areas related to the default mode network. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/24237038/The_association_between_biomarkers_in_cerebrospinal_fluid_and_structural_changes_in_the_brain_in_patients_with_Alzheimer's_disease_ L2 - https://doi.org/10.1111/joim.12164 DB - PRIME DP - Unbound Medicine ER -