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Lyme disease during pregnancy.

Abstract

Lyme disease is an increasingly recognized tick-borne illness caused by a spirochete, Borrelia burgdorferi. Because the etiologic agent of Lyme disease is a spirochete, there has been concern about the effect of maternal Lyme disease on pregnancy outcome. We reviewed cases of Lyme disease in pregnant women who were identified before knowledge of the pregnancy outcomes. Nineteen cases were identified with onset between 1976 and 1984. Eight of the women were affected during the first trimester, seven during the second trimester, and two during the third trimester; in two, the trimester of onset was unknown. Thirteen received appropriate antibiotic therapy for Lyme disease. Of the 19 pregnancies, five had adverse outcomes, including syndactyly, cortical blindness, intrauterine fetal death, prematurity, and rash in the newborn. Adverse outcomes occurred in cases with infection during each of the trimesters. Although B burgdorferi could not be implicated directly in any of the adverse outcomes, the frequency of such outcomes warrants further surveillance and studies of pregnant women with Lyme disease.

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  • Publisher Full Text
  • Authors

    , , , ,

    Source

    JAMA 255:24 1986 Jun 27 pg 3394-6

    MeSH

    Adult
    Blindness
    Dermatitis
    Developmental Disabilities
    Female
    Fetal Death
    Humans
    Infant, Newborn
    Infant, Premature
    Lyme Disease
    Penicillins
    Pregnancy
    Pregnancy Complications, Infectious
    Pregnancy Trimester, First
    Pregnancy Trimester, Second
    Pregnancy Trimester, Third
    Syndactyly

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    2423719

    Citation

    TY - JOUR T1 - Lyme disease during pregnancy. AU - Markowitz,L E, AU - Steere,A C, AU - Benach,J L, AU - Slade,J D, AU - Broome,C V, PY - 1986/6/27/pubmed PY - 1986/6/27/medline PY - 1986/6/27/entrez SP - 3394 EP - 6 JF - JAMA JO - JAMA VL - 255 IS - 24 N2 - Lyme disease is an increasingly recognized tick-borne illness caused by a spirochete, Borrelia burgdorferi. Because the etiologic agent of Lyme disease is a spirochete, there has been concern about the effect of maternal Lyme disease on pregnancy outcome. We reviewed cases of Lyme disease in pregnant women who were identified before knowledge of the pregnancy outcomes. Nineteen cases were identified with onset between 1976 and 1984. Eight of the women were affected during the first trimester, seven during the second trimester, and two during the third trimester; in two, the trimester of onset was unknown. Thirteen received appropriate antibiotic therapy for Lyme disease. Of the 19 pregnancies, five had adverse outcomes, including syndactyly, cortical blindness, intrauterine fetal death, prematurity, and rash in the newborn. Adverse outcomes occurred in cases with infection during each of the trimesters. Although B burgdorferi could not be implicated directly in any of the adverse outcomes, the frequency of such outcomes warrants further surveillance and studies of pregnant women with Lyme disease. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/2423719/abstract/Lyme_disease_during_pregnancy_ L2 - http://jama.jamanetwork.com/article.aspx?volume=255&page=3394 ER -