Tags

Type your tag names separated by a space and hit enter

Prospective association between dietary fiber intake and breast cancer risk.
PLoS One. 2013; 8(11):e79718.Plos

Abstract

BACKGROUND

Mechanistic hypotheses suggest a potential effect of dietary fiber on breast carcinogenesis through the modulation of insulin-like growth factor bioactivity, estrogen metabolism and inflammation. An association between dietary fiber intake and breast cancer risk has been suggested in epidemiological studies but remains inconclusive. In particular, data is lacking regarding the different types of dietary fibers.

OBJECTIVE

The objective was to investigate the prospective relationship between dietary fiber intake and breast cancer risk, taking into account different types of dietary fiber (overall, insoluble, soluble and from different food sources: cereals, vegetables, fruits and legumes).

DESIGN

4684 women from the SU.VI.MAX cohort were included in this analysis as they completed at least three 24h-dietary records within the first two years of follow-up. Among them, 167 incident invasive breast cancers were diagnosed during a median follow-up of 12.6 years (between 1994 and 2007). The associations between quartiles of dietary fiber intake and breast cancer risk were characterized using multivariate Cox proportional hazards models.

RESULTS

Total fiber intake was not associated with breast cancer risk (HR(Quartile4vs.Quartile1) = 1.29 (95%CI 0.66-2.50), P-trend = 0.5), nor was fiber intake from cereals (P-trend = 0.1), fruits (P-trend = 0.9) and legumes (P-trend = 0.3). In contrast, vegetable fiber intake was related to a decreased risk of breast cancer (HR(Q4vs.Q1) = 0.50 (0.29-0.88), P-trend = 0.03). Overall vegetable intake (in g/day) was not associated with breast cancer risk (P-trend = 0.2).

CONCLUSION

This prospective study suggests that vegetable fiber intake may contribute to reduce breast cancer risk, in line with experimental mechanistic data.

Authors+Show Affiliations

Nutritional Epidemiology Research Team, Sorbonne Paris Cité Research Center, Inserm (U557), Inra (U1125), Cnam, Paris 13 University, SMBH Paris 13, Bobigny, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24244548

Citation

Deschasaux, Mélanie, et al. "Prospective Association Between Dietary Fiber Intake and Breast Cancer Risk." PloS One, vol. 8, no. 11, 2013, pp. e79718.
Deschasaux M, Zelek L, Pouchieu C, et al. Prospective association between dietary fiber intake and breast cancer risk. PLoS ONE. 2013;8(11):e79718.
Deschasaux, M., Zelek, L., Pouchieu, C., His, M., Hercberg, S., Galan, P., Latino-Martel, P., & Touvier, M. (2013). Prospective association between dietary fiber intake and breast cancer risk. PloS One, 8(11), e79718. https://doi.org/10.1371/journal.pone.0079718
Deschasaux M, et al. Prospective Association Between Dietary Fiber Intake and Breast Cancer Risk. PLoS ONE. 2013;8(11):e79718. PubMed PMID: 24244548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective association between dietary fiber intake and breast cancer risk. AU - Deschasaux,Mélanie, AU - Zelek,Laurent, AU - Pouchieu,Camille, AU - His,Mathilde, AU - Hercberg,Serge, AU - Galan,Pilar, AU - Latino-Martel,Paule, AU - Touvier,Mathilde, Y1 - 2013/11/14/ PY - 2013/07/25/received PY - 2013/10/03/accepted PY - 2013/11/19/entrez PY - 2013/11/19/pubmed PY - 2014/12/15/medline SP - e79718 EP - e79718 JF - PloS one JO - PLoS ONE VL - 8 IS - 11 N2 - BACKGROUND: Mechanistic hypotheses suggest a potential effect of dietary fiber on breast carcinogenesis through the modulation of insulin-like growth factor bioactivity, estrogen metabolism and inflammation. An association between dietary fiber intake and breast cancer risk has been suggested in epidemiological studies but remains inconclusive. In particular, data is lacking regarding the different types of dietary fibers. OBJECTIVE: The objective was to investigate the prospective relationship between dietary fiber intake and breast cancer risk, taking into account different types of dietary fiber (overall, insoluble, soluble and from different food sources: cereals, vegetables, fruits and legumes). DESIGN: 4684 women from the SU.VI.MAX cohort were included in this analysis as they completed at least three 24h-dietary records within the first two years of follow-up. Among them, 167 incident invasive breast cancers were diagnosed during a median follow-up of 12.6 years (between 1994 and 2007). The associations between quartiles of dietary fiber intake and breast cancer risk were characterized using multivariate Cox proportional hazards models. RESULTS: Total fiber intake was not associated with breast cancer risk (HR(Quartile4vs.Quartile1) = 1.29 (95%CI 0.66-2.50), P-trend = 0.5), nor was fiber intake from cereals (P-trend = 0.1), fruits (P-trend = 0.9) and legumes (P-trend = 0.3). In contrast, vegetable fiber intake was related to a decreased risk of breast cancer (HR(Q4vs.Q1) = 0.50 (0.29-0.88), P-trend = 0.03). Overall vegetable intake (in g/day) was not associated with breast cancer risk (P-trend = 0.2). CONCLUSION: This prospective study suggests that vegetable fiber intake may contribute to reduce breast cancer risk, in line with experimental mechanistic data. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24244548/Prospective_association_between_dietary_fiber_intake_and_breast_cancer_risk_ L2 - http://dx.plos.org/10.1371/journal.pone.0079718 DB - PRIME DP - Unbound Medicine ER -