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Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece.
Sci Total Environ. 2014 Feb 01; 470-471:1243-9.ST

Abstract

Biomonitoring of human exposure to bisphenol A diglycidyl ethers (BADGEs; resin coating for food cans), p-hydroxybenzoic acid esters (parabens; preservatives), benzophenone-type UV filters (BP-UV filters; sunscreen agents), triclosan (TCS; antimicrobials), and triclocarban (TCC; antimicrobials) has been investigated in western European countries and North America. Nevertheless, little is known about the exposure of Greek populations to these environmental chemicals. In this study, 100 urine samples collected from Athens, Greece, were analyzed by liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for the determination of total concentrations of five derivatives of BADGEs, six parabens and their metabolite (ethyl-protocatechuate), five derivatives of BP-UV filters, TCS, and TCC. Urinary concentrations of BADGEs, parabens, ethyl-protocatechuate, BP-UV filters, TCS and TCC (on a volume basis) ranged 0.3-20.9 (geometric mean: 0.9), 1.6-1010 (24.2), <2-71.0 (2.1), 0.5-1120 (4.4), <0.5-2580 (8.0) and <0.5-1.9 (0.6) ng/mL, respectively. All 19 target chemicals were found in urine, and the highest detection rates were observed for methyl paraben (100%), bisphenol A bis (2,3-dihydroxypropyl) ether (90%), ethyl paraben (87%), 2,4-dihydroxybenzophenone (78%), propyl paraben (72%), and TCS (71%). Estimated daily intakes (EDIurine), calculated on the basis of the measured urinary concentrations, ranged from 0.023 μg/kg bw/day for Σ5BADGEs to 31.4 μg/kg bw/day for Σ6Parabens.

Authors+Show Affiliations

Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, New York, USA; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece.Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece.Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, New York, USA. Electronic address: kkannan@wadsworth.org.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

24246946

Citation

Asimakopoulos, Alexandros G., et al. "Widespread Occurrence of Bisphenol a Diglycidyl Ethers, P-hydroxybenzoic Acid Esters (parabens), Benzophenone type-UV Filters, Triclosan, and Triclocarban in Human Urine From Athens, Greece." The Science of the Total Environment, vol. 470-471, 2014, pp. 1243-9.
Asimakopoulos AG, Thomaidis NS, Kannan K. Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. Sci Total Environ. 2014;470-471:1243-9.
Asimakopoulos, A. G., Thomaidis, N. S., & Kannan, K. (2014). Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. The Science of the Total Environment, 470-471, 1243-9. https://doi.org/10.1016/j.scitotenv.2013.10.089
Asimakopoulos AG, Thomaidis NS, Kannan K. Widespread Occurrence of Bisphenol a Diglycidyl Ethers, P-hydroxybenzoic Acid Esters (parabens), Benzophenone type-UV Filters, Triclosan, and Triclocarban in Human Urine From Athens, Greece. Sci Total Environ. 2014 Feb 1;470-471:1243-9. PubMed PMID: 24246946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. AU - Asimakopoulos,Alexandros G, AU - Thomaidis,Nikolaos S, AU - Kannan,Kurunthachalam, Y1 - 2013/11/16/ PY - 2013/09/27/received PY - 2013/10/25/revised PY - 2013/10/25/accepted PY - 2013/11/20/entrez PY - 2013/11/20/pubmed PY - 2014/8/15/medline KW - 2,2′,4,4′-OH-BP or BP-2 KW - 2,2′,4,4′-tetrahydroxybenzophenone KW - 2,2′-OH-4MeO-BP or BP-8 KW - 2,2′-dihydroxy-4-methoxybenzophenone KW - 2,3,4-OH-BP KW - 2,3,4-trihydroxybenzophenone KW - 2,4-OH-BP or BP-1 KW - 2,4-dihydroxybenzophenone KW - 4-OH-BP KW - 4-hydroxybenzophenone KW - BADGEs KW - BADGE•2H(2)O KW - BADGE•H(2)O KW - BADGE•HCl KW - BADGE•HCl•H(2)O KW - BP-UV filters KW - Benzophenones KW - Biomonitoring KW - Bisphenol A diglycidyl ethers KW - BuP KW - BzP KW - EtP KW - HeptP KW - MeP KW - OH-EtP KW - Parabens KW - PrP KW - TCC KW - TCS KW - Triclosan KW - Urine KW - benzophenone-type UV filters KW - benzyl paraben KW - bisphenol A (2,3-dihydroxypropyl) glycidyl ether KW - bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether KW - bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether KW - bisphenol A bis (2,3-dihydroxypropyl) ether KW - butyl paraben KW - ethyl paraben KW - ethyl-protocatechuate KW - heptyl paraben KW - methyl paraben KW - p-hydroxybenzoic acid esters KW - parabens KW - propyl paraben KW - triclocarban KW - triclosan SP - 1243 EP - 9 JF - The Science of the total environment JO - Sci. Total Environ. VL - 470-471 N2 - Biomonitoring of human exposure to bisphenol A diglycidyl ethers (BADGEs; resin coating for food cans), p-hydroxybenzoic acid esters (parabens; preservatives), benzophenone-type UV filters (BP-UV filters; sunscreen agents), triclosan (TCS; antimicrobials), and triclocarban (TCC; antimicrobials) has been investigated in western European countries and North America. Nevertheless, little is known about the exposure of Greek populations to these environmental chemicals. In this study, 100 urine samples collected from Athens, Greece, were analyzed by liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for the determination of total concentrations of five derivatives of BADGEs, six parabens and their metabolite (ethyl-protocatechuate), five derivatives of BP-UV filters, TCS, and TCC. Urinary concentrations of BADGEs, parabens, ethyl-protocatechuate, BP-UV filters, TCS and TCC (on a volume basis) ranged 0.3-20.9 (geometric mean: 0.9), 1.6-1010 (24.2), <2-71.0 (2.1), 0.5-1120 (4.4), <0.5-2580 (8.0) and <0.5-1.9 (0.6) ng/mL, respectively. All 19 target chemicals were found in urine, and the highest detection rates were observed for methyl paraben (100%), bisphenol A bis (2,3-dihydroxypropyl) ether (90%), ethyl paraben (87%), 2,4-dihydroxybenzophenone (78%), propyl paraben (72%), and TCS (71%). Estimated daily intakes (EDIurine), calculated on the basis of the measured urinary concentrations, ranged from 0.023 μg/kg bw/day for Σ5BADGEs to 31.4 μg/kg bw/day for Σ6Parabens. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/24246946/Widespread_occurrence_of_bisphenol_A_diglycidyl_ethers_p_hydroxybenzoic_acid_esters__parabens__benzophenone_type_UV_filters_triclosan_and_triclocarban_in_human_urine_from_Athens_Greece_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(13)01233-3 DB - PRIME DP - Unbound Medicine ER -