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Milk consumption during teenage years and risk of hip fractures in older adults.
JAMA Pediatr 2014; 168(1):54-60JP

Abstract

IMPORTANCE

Milk consumption during adolescence is recommended to promote peak bone mass and thereby reduce fracture risk in later life. However, its role in hip fracture prevention is not established and high consumption may adversely influence risk by increasing height.

OBJECTIVES

To determine whether milk consumption during teenage years influences risk of hip fracture in older adults and to investigate the role of attained height in this association.

DESIGN, SETTING, AND PARTICIPANTS

Prospective cohort study over 22 years of follow-up in more than 96,000 white postmenopausal women from the Nurses' Health Study and men aged 50 years and older from the Health Professionals Follow-up Study in the United States.

EXPOSURES

Frequency of consumption of milk and other foods during ages 13 to 18 years and attained height were reported at baseline. Current diet, weight, smoking, physical activity, medication use, and other risk factors for hip fractures were reported on biennial questionnaires.

MAIN OUTCOMES AND MEASURES

Cox proportional hazards models were used to calculate relative risks (RRs) of first incidence of hip fracture from low-trauma events per glass (8 fl oz or 240 mL) of milk consumed per day during teenage years.

RESULTS

During follow-up, 1226 hip fractures were identified in women and 490 in men. After controlling for known risk factors and current milk consumption, each additional glass of milk per day during teenage years was associated with a significant 9% higher risk of hip fracture in men (RR = 1.09; 95% CI, 1.01-1.17). The association was attenuated when height was added to the model (RR = 1.06; 95% CI, 0.98-1.14). Teenage milk consumption was not associated with hip fractures in women (RR = 1.00 per glass per day; 95% CI, 0.95-1.05).

CONCLUSIONS AND RELEVANCE

Greater milk consumption during teenage years was not associated with a lower risk of hip fracture in older adults. The positive association observed in men was partially mediated through attained height.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts.Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland3Department of Rheumatology and Institute for Physical Medicine and Rehabilitation, University Hospital Zurich, Zurich, Switzerland.Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts4Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Harvard University, Bos.Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts5Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts6Department.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24247817

Citation

Feskanich, Diane, et al. "Milk Consumption During Teenage Years and Risk of Hip Fractures in Older Adults." JAMA Pediatrics, vol. 168, no. 1, 2014, pp. 54-60.
Feskanich D, Bischoff-Ferrari HA, Frazier AL, et al. Milk consumption during teenage years and risk of hip fractures in older adults. JAMA Pediatr. 2014;168(1):54-60.
Feskanich, D., Bischoff-Ferrari, H. A., Frazier, A. L., & Willett, W. C. (2014). Milk consumption during teenage years and risk of hip fractures in older adults. JAMA Pediatrics, 168(1), pp. 54-60. doi:10.1001/jamapediatrics.2013.3821.
Feskanich D, et al. Milk Consumption During Teenage Years and Risk of Hip Fractures in Older Adults. JAMA Pediatr. 2014;168(1):54-60. PubMed PMID: 24247817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk consumption during teenage years and risk of hip fractures in older adults. AU - Feskanich,Diane, AU - Bischoff-Ferrari,Heike A, AU - Frazier,A Lindsay, AU - Willett,Walter C, PY - 2013/11/20/entrez PY - 2013/11/20/pubmed PY - 2014/3/7/medline SP - 54 EP - 60 JF - JAMA pediatrics JO - JAMA Pediatr VL - 168 IS - 1 N2 - IMPORTANCE: Milk consumption during adolescence is recommended to promote peak bone mass and thereby reduce fracture risk in later life. However, its role in hip fracture prevention is not established and high consumption may adversely influence risk by increasing height. OBJECTIVES: To determine whether milk consumption during teenage years influences risk of hip fracture in older adults and to investigate the role of attained height in this association. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study over 22 years of follow-up in more than 96,000 white postmenopausal women from the Nurses' Health Study and men aged 50 years and older from the Health Professionals Follow-up Study in the United States. EXPOSURES: Frequency of consumption of milk and other foods during ages 13 to 18 years and attained height were reported at baseline. Current diet, weight, smoking, physical activity, medication use, and other risk factors for hip fractures were reported on biennial questionnaires. MAIN OUTCOMES AND MEASURES: Cox proportional hazards models were used to calculate relative risks (RRs) of first incidence of hip fracture from low-trauma events per glass (8 fl oz or 240 mL) of milk consumed per day during teenage years. RESULTS: During follow-up, 1226 hip fractures were identified in women and 490 in men. After controlling for known risk factors and current milk consumption, each additional glass of milk per day during teenage years was associated with a significant 9% higher risk of hip fracture in men (RR = 1.09; 95% CI, 1.01-1.17). The association was attenuated when height was added to the model (RR = 1.06; 95% CI, 0.98-1.14). Teenage milk consumption was not associated with hip fractures in women (RR = 1.00 per glass per day; 95% CI, 0.95-1.05). CONCLUSIONS AND RELEVANCE: Greater milk consumption during teenage years was not associated with a lower risk of hip fracture in older adults. The positive association observed in men was partially mediated through attained height. SN - 2168-6211 UR - https://www.unboundmedicine.com/medline/citation/24247817/Milk_consumption_during_teenage_years_and_risk_of_hip_fractures_in_older_adults_ L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2013.3821 DB - PRIME DP - Unbound Medicine ER -