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Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond.
J Nephrol. 2013 Nov-Dec; 26(6):960-74.JN

Abstract

Replacement of dietary saturated fat with unsaturated fat has been recommended for prevention of cardiovascular disease (CVD) in the general population. Less is known of the health risks in individuals with chronic kidney disease (CKD), of a diet with an unhealthy fat profile, in general characterized by insufficient polyunsaturated fatty acids (PUFA) and excess satu-rated fatty acids (SFA). The dietary intake of PUFA, both the n-3 and n-6 subfamilies, is increasingly gaining attention in CKD, owing to its broad cardioprotective effects. Conversely, dietary SFA may promote CVD in this vulnerable population. This review discusses the potential benefits of dietary fat modification in CKD patients, including plausible effects on renal function, albuminuria, lipoproteins, nutritional status, inflammation, thrombosis and clinical outcomes. Increasing evidence supports the concept that n-3 PUFA might have therapeutic potential in reducing proteinuria in CKD and reducing triglycerides and inflammation in dialysis patients. In addition, emerging evidence suggests that linoleic acid, a major n-6 PUFA derived from vegetable oils, may be beneficial for a number of CVD risk factors. Increased consumption of oily fish as part of plant-based diets with low content of SFA is likely to benefit patients who have CKD, or are at risk of developing CKD. Such recommendations are in line with the concept of a healthy "Mediterranean diet" and are in line with current dietary recommendations for CVD prevention in the community.

Authors+Show Affiliations

Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm - Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24249210

Citation

Huang, Xiaoyan, et al. "Dietary Fat Modification in Patients With Chronic Kidney Disease: N-3 Fatty Acids and Beyond." Journal of Nephrology, vol. 26, no. 6, 2013, pp. 960-74.
Huang X, Lindholm B, Stenvinkel P, et al. Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond. J Nephrol. 2013;26(6):960-74.
Huang, X., Lindholm, B., Stenvinkel, P., & Carrero, J. J. (2013). Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond. Journal of Nephrology, 26(6), 960-74. https://doi.org/10.5301/jn.5000284
Huang X, et al. Dietary Fat Modification in Patients With Chronic Kidney Disease: N-3 Fatty Acids and Beyond. J Nephrol. 2013 Nov-Dec;26(6):960-74. PubMed PMID: 24249210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond. AU - Huang,Xiaoyan, AU - Lindholm,Bengt, AU - Stenvinkel,Peter, AU - Carrero,Juan Jesús, Y1 - 2013/10/03/ PY - 2013/03/26/accepted PY - 2013/11/20/entrez PY - 2013/11/20/pubmed PY - 2015/6/9/medline SP - 960 EP - 74 JF - Journal of nephrology JO - J Nephrol VL - 26 IS - 6 N2 - Replacement of dietary saturated fat with unsaturated fat has been recommended for prevention of cardiovascular disease (CVD) in the general population. Less is known of the health risks in individuals with chronic kidney disease (CKD), of a diet with an unhealthy fat profile, in general characterized by insufficient polyunsaturated fatty acids (PUFA) and excess satu-rated fatty acids (SFA). The dietary intake of PUFA, both the n-3 and n-6 subfamilies, is increasingly gaining attention in CKD, owing to its broad cardioprotective effects. Conversely, dietary SFA may promote CVD in this vulnerable population. This review discusses the potential benefits of dietary fat modification in CKD patients, including plausible effects on renal function, albuminuria, lipoproteins, nutritional status, inflammation, thrombosis and clinical outcomes. Increasing evidence supports the concept that n-3 PUFA might have therapeutic potential in reducing proteinuria in CKD and reducing triglycerides and inflammation in dialysis patients. In addition, emerging evidence suggests that linoleic acid, a major n-6 PUFA derived from vegetable oils, may be beneficial for a number of CVD risk factors. Increased consumption of oily fish as part of plant-based diets with low content of SFA is likely to benefit patients who have CKD, or are at risk of developing CKD. Such recommendations are in line with the concept of a healthy "Mediterranean diet" and are in line with current dietary recommendations for CVD prevention in the community. SN - 1724-6059 UR - https://www.unboundmedicine.com/medline/citation/24249210/Dietary_fat_modification_in_patients_with_chronic_kidney_disease:_n_3_fatty_acids_and_beyond_ DB - PRIME DP - Unbound Medicine ER -