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Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris.
Lasers Surg Med. 2013 Dec; 45(10):639-47.LS

Abstract

BACKGROUND AND OBJECTIVE

A minimally invasive fractional radiofrequency microneedle (FRM) device has been used in skin rejuvenation and acne scars, and a recent pilot study demonstrated the positive therapeutic effect on acne. We evaluated the efficacy of FRM device for acne vulgaris in Asians and conducted objective measurement to assess its effect on sebum production.

PATIENTS AND METHODS

Twenty Korean patients with acne vulgaris received a single full-face FRM treatment. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, acne lesion count, and objective measurements of casual sebum level (CSL) and sebum excretion rate (SER). They were evaluated at baseline and 2, 4, 8 weeks after the treatment.

RESULTS

After a single FRM treatment, the CSL and the SER showed 30-60% and 70-80% reduction, respectively, at week 2 (P < 0.01), and remained below the baseline level until week 8. Physician's global improvement scores for acne severity and acne lesion count also revealed clinical improvement with maximum efficacy at week 2, but returned to the baseline in most patients by week 8. Patients' satisfaction scores (0-4) were above 2 on average, and adverse effects were minimal.

CONCLUSION

This prospective study demonstrated the sebosuppressive effect from a single FRM treatment, but its therapeutic efficacy in acne requires further evaluation.

Authors+Show Affiliations

Korea Dermatology Research Institute (KDRI), Seongnam-si, Gyeonggi-do, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

24249246

Citation

Lee, Kyung Real, et al. "Assessment of Treatment Efficacy and Sebosuppressive Effect of Fractional Radiofrequency Microneedle On Acne Vulgaris." Lasers in Surgery and Medicine, vol. 45, no. 10, 2013, pp. 639-47.
Lee KR, Lee EG, Lee HJ, et al. Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris. Lasers Surg Med. 2013;45(10):639-47.
Lee, K. R., Lee, E. G., Lee, H. J., & Yoon, M. S. (2013). Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris. Lasers in Surgery and Medicine, 45(10), 639-47. https://doi.org/10.1002/lsm.22200
Lee KR, et al. Assessment of Treatment Efficacy and Sebosuppressive Effect of Fractional Radiofrequency Microneedle On Acne Vulgaris. Lasers Surg Med. 2013;45(10):639-47. PubMed PMID: 24249246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris. AU - Lee,Kyung Real, AU - Lee,Eo Gin, AU - Lee,Hee Jung, AU - Yoon,Moon Soo, Y1 - 2013/11/19/ PY - 2013/10/21/accepted PY - 2013/11/20/entrez PY - 2013/11/20/pubmed PY - 2014/8/26/medline KW - acne vulgaris KW - fractional radiofrequency microneedle KW - sebum excretion SP - 639 EP - 47 JF - Lasers in surgery and medicine JO - Lasers Surg Med VL - 45 IS - 10 N2 - BACKGROUND AND OBJECTIVE: A minimally invasive fractional radiofrequency microneedle (FRM) device has been used in skin rejuvenation and acne scars, and a recent pilot study demonstrated the positive therapeutic effect on acne. We evaluated the efficacy of FRM device for acne vulgaris in Asians and conducted objective measurement to assess its effect on sebum production. PATIENTS AND METHODS: Twenty Korean patients with acne vulgaris received a single full-face FRM treatment. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, acne lesion count, and objective measurements of casual sebum level (CSL) and sebum excretion rate (SER). They were evaluated at baseline and 2, 4, 8 weeks after the treatment. RESULTS: After a single FRM treatment, the CSL and the SER showed 30-60% and 70-80% reduction, respectively, at week 2 (P < 0.01), and remained below the baseline level until week 8. Physician's global improvement scores for acne severity and acne lesion count also revealed clinical improvement with maximum efficacy at week 2, but returned to the baseline in most patients by week 8. Patients' satisfaction scores (0-4) were above 2 on average, and adverse effects were minimal. CONCLUSION: This prospective study demonstrated the sebosuppressive effect from a single FRM treatment, but its therapeutic efficacy in acne requires further evaluation. SN - 1096-9101 UR - https://www.unboundmedicine.com/medline/citation/24249246/Assessment_of_treatment_efficacy_and_sebosuppressive_effect_of_fractional_radiofrequency_microneedle_on_acne_vulgaris_ L2 - https://doi.org/10.1002/lsm.22200 DB - PRIME DP - Unbound Medicine ER -